英文药名: Humira (Adalimumab Injection Syringes)
HUMIRA is a recombinant fully human lgG1 monoclonal antibody, which binds specifically to tumor necrosis factor alpha (TNF-a). What is HUMIRA indicated for? HUMIRA is indicated for reducing signs and symptoms and inducing and maintaining clinical remission in adult patients with severe, active Crohn’s disease who have not responded to conventional therapy. How does HUMIRA work? TNF is a naturally occurring proinflammatory cytokine that is involved in normal inflammatory immune responses. HUMIRA blinds specifically to TNF-a, and blocks its reaction with p55 and p75 call surface TNF receptors. What role does TNF-a Play in Crohn’s disease? TNF has been identified as an important cytokine involved in the pathogenesis of Crohn’s Disease. Elevated levels of TNF-a are found on the stool, mucosa, and blood of patients with Crohn’s Disease. What technology was used to create HUMIRA? HUMIRA is a recombinant human lgG1 monoclonal antibody specific for human TNF. HUMIRA was created using phage display technology, resulting in an antibody with human-derived heavy and light chain variable regions with specificity for human TNF. How is HUMIRA administrated? HUMIRA can be self-administrated by subcutaneous injection at home or anywhere, although it is recommended that healthcare professionals train and supervise patients during administration of the first 4 injections. HUMIRA is available as a single-use, 0.8 ml prefilled glass syringe. |
Humira (Adalimumab Injection Syringes)阿达木单抗注射液简介:
英文药名: Humira (Adalimumab Injection Syringes)中文药名: 阿达木单抗注射液注射器生产厂家: Abbott 10月的美国《关节炎和风湿病》(《ArthritisRheum》)杂志上发表的一项报告称,抗肿瘤坏死因子的人 ... 责任编辑:admin |
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