英文药名: Humira (Adalimumab Injection Syringes)
中文药名: 阿达木单抗注射液注射器
生产厂家: Abbott
  10月的美国《关节炎和风湿病》(《ArthritisRheum》)杂志上发表的一项报告称，抗肿瘤坏死因子的人单科隆抗体阿达木单抗(Humira)科显著改善中度至严重活动性银屑病关节炎的临床表现。
  位于华盛顿州西雅图的瑞典医疗中心菲利普.J.米斯医生及其同事在研究中每两周给予患者40毫克阿达木单抗皮下注射，并评估了315例活动性银屑病关节炎患者的治疗效果。
  研究者报告，在为期24周的研究过程中，使用阿达木单抗治疗的患者在所有时间点的美国风湿病学会(ACR)反应率显著高于安慰剂组。达到AR20反应(ACR类风湿关节炎改善基本定义)的患者阿达木单抗组为5%，安慰剂组为4%。早在研究的第二周，阿达木单抗组的ACR反应就显著较好。在治疗方案中增加甲氨蝶呤，不改善反应。X线片显示阿达木单抗治疗还显著一直结构改变，显著减轻皮肤银屑病的扩展。与安慰剂组比较，接受阿达木单抗治疗的患者残疾程度显著改善，并维持到24周。两族的不良时间发生率类似，只是丙氨酸氨基转移酶的短暂提高在阿达木单抗组更常见。
作者解释说。近期的研究显示其他抗肿瘤坏死因子可有效地治疗银屑病关节炎和银屑病，阿达木单抗已显示对中度至严重类风湿性关节炎患者有意。阿达木单抗可有效治疗银屑病的各个方面，使其有希望成为银屑病治疗的一种新药。

HUMIRA is a recombinant fully human lgG1 monoclonal antibody, which binds specifically to tumor necrosis factor alpha (TNF-a).

What is HUMIRA indicated for?

HUMIRA is indicated for reducing signs and symptoms and inducing and maintaining clinical remission in adult patients with severe, active Crohn’s disease who have not responded to conventional therapy.

How does HUMIRA work?

TNF is a naturally occurring proinflammatory cytokine that is involved in normal inflammatory immune responses. HUMIRA blinds specifically to TNF-a, and blocks its reaction with p55 and p75 call surface TNF receptors.

What role does TNF-a Play in Crohn’s disease?

TNF has been identified as an important cytokine involved in the pathogenesis of Crohn’s Disease. Elevated levels of TNF-a are found on the stool, mucosa, and blood of patients with Crohn’s Disease.

What technology was used to create HUMIRA?

HUMIRA is a recombinant human lgG1 monoclonal antibody specific for human TNF. HUMIRA was created using phage display technology, resulting in an antibody with human-derived heavy and light chain variable regions with specificity for human TNF.

How is HUMIRA administrated?

HUMIRA can be self-administrated by subcutaneous injection at home or anywhere, although it is recommended that healthcare professionals train and supervise patients during administration of the first 4 injections. HUMIRA is available as a single-use, 0.8 ml prefilled glass syringe.