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当前位置:药品说明书与价格首页 >> 糖尿病 >> 新药推荐 >> 磷酸西他列汀片Januvia—糖尿病药物新突破

磷酸西他列汀片Januvia—糖尿病药物新突破

2010-01-14 16:03:42  作者:新特药房  来源:中国新特药网  浏览次数:1249  文字大小:【】【】【
简介: 随着临床对糖尿病研究的深入,治疗糖尿病的药物品种越来越来多。研究发现,不少降糖药物无法根本阻止胰岛β细胞的进一步损坏,有的更掠夺式地“促进”胰岛素分泌,最终“累坏”了胰腺,病人只能依赖注 ...

 随着临床对糖尿病研究的深入,治疗糖尿病的药物品种越来越来多。研究发现,不少降糖药物无法根本阻止胰岛β细胞的进一步损坏,有的更掠夺式地“促进”胰岛素分泌,最终“累坏”了胰腺,病人只能依赖注射胰岛素。因此,研究不损伤胰岛β细胞甚至具有β细胞保护作用的新型降糖药成为糖尿病治疗药物研究的热点。

近年来研究发现,DPP-4抑制剂能够增强一种名为肠降血糖系统的人体生理性系统,产生生理性降糖”功效。这个生理系统自身能够影响胰岛的β细胞和α细胞,有助于调节葡萄糖,而且只有β细胞功能紊乱造成胰岛素减少引起血糖升高,或因α细胞和β细胞功能紊乱造成肝脏葡萄糖合成失控进而引发血糖升高,DPP-4才会产生药效。

DPP-4存在葡萄糖水平依赖性,它不会一味地只知道降糖,更不会掠夺性地压榨胰岛,耗竭胰腺的功能。相反,试验证明,它具有长期保护人类β细胞的前景。此外,它不会导致体重增加、血糖降低等的副反应,患者对药物依从性也会大大提高。因此,理论上它的有效作用年限会大大超过目前的口服降糖药,患者的胰岛素依赖会大大延缓。

磷酸西他列汀片(Januvia)是临床首个获批准用于治疗2型糖尿病的DPP-4抑制剂,由Meek Sharp&Dohme Ltd.公司开发研制,并于2006年在墨西哥及美国上市,2007年也获得欧盟批准用于治疗2型糖尿病。中国批准在即,目前磷酸西他列汀片已成为美国口服糖尿病药物的第二大药物。

磷酸西他列汀片作为目前最具发展前途的新型降糖药物,日后正式在我国上市后必定给2型糖尿病患者带来新的希望。

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About JANUVIA

 

JANUVIA is a once-daily pill that, along with diet and exercise, helps lower blood sugar levels in people with type 2 diabetes. It's a type of prescription diabetes medicine called a DPP-4 inhibitor (blocker). DPP-4 blockers enhance the body's own ability to control blood sugar levels.

A doctor may prescribe JANUVIA alone or together with certain other diabetes medicines to help control blood sugar.

JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in people with type 2 diabetes.

Important Information About JANUVIA

JANUVIA has not been studied with insulin and should not be used to treat patients with type 1 diabetes or diabetic ketoacidosis (increased ketones in the blood or urine) or used if you are allergic to JANUVIA. Your doctor may perform blood tests from time to time to measure how well your kidneys are working. If you have kidney problems, your doctor may prescribe lower doses of JANUVIA.

When JANUVIA is used with a sulfonylurea, low blood sugar (hypoglycemia) can occur. To avoid this risk, your doctor may prescribe lower doses of the sulfonylurea.

Allergic reactions, which may be serious, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have an allergic reaction, stop taking JANUVIA and call your doctor right away. The most common side effects include upper respiratory tract infection, stuffy or runny nose and sore throat, and headache.
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Information on Januvia

Learn more about usage, cautions, and possible side effects .

Bottle
Chemical Name: SITAGLIPTIN (si-ta-GLIP-tin)

Common uses
This medicine is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise. It is used along with diet and exercise. This medicine may be taken alone or in combination with certain other antidiabetic medicines.

Before using
INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking digoxin. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including kidney problems, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have type 1 diabetes or high blood ketone levels (diabetic ketoacidosis). Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

Directions
Follow the directions for using this medicine provided by your doctor. An additional patient information leaflet is available with this medicine. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. This medicine may be taken on an empty stomach or with food. STORE THIS MEDICINE at room temperature between 68 and 77 degrees F (20 and 25 degrees C) away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.

Cautions
DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. Laboratory and/or medical tests, including blood glucose, hemoglobin A1C, and kidney function, may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. It may be harder for you to control your blood sugar during times of stress such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby. CHECK BLOOD SUGAR LEVELS closely and ask your doctor before adjusting the dose of your diabetes medicine. MONITOR BLOOD GLUCOSE on a regular basis, as directed by your doctor.

Possible side effects
SIDE EFFECTS that may occur while taking this medicine include headache, nausea, nasal congestion, runny nose, sore throat, or upper respiratory infection. If they continue or are bothersome, check with your doctor. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Drug interactions
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions

If you take too much
IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately.

Additional information
If your symptoms do not improve or if they become worse, check with your doctor. FOLLOW THE DIETARY PLAN provided by your doctor. Carry an identification card at all times that says you are diabetic. Monitor your blood sugar levels regularly according to your doctor's directions. If your blood sugar level is often higher or lower than it should be and you are taking this medicine according to directions, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children.
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美国默克糖尿病治疗新药Januvia通过欧洲批准

美国默克制药公司每日用药一次的糖尿病治疗新药Januvia(sitagliptin)昨日通过欧洲批准。该药是第一种通过欧洲批准的二肽酰肽酶4(DPP-4)抑制剂类糖尿病复方治疗药。

Januvia用于治疗2型糖尿病,它通过提高人体降糖素系统的机能而降低血糖水平。当人体血糖水平升高时,降糖素通过两种方式控制血糖水平:其一是促使胰腺释放胰岛素;其二是向肝脏发送信号以降低葡萄糖的生成。DPP-4抑制剂可以通过增加人体降糖素的活性而帮助2型糖尿病患者控制血糖水平特别值得指出的是,当单独使用Januvia效果不理想时,该药可与metformin联用,再结合饮食和运动而达到更好的疗效。同时,它还获准与thiazolidinedione联用。
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【原产地英文商品名】Januvia 10MGx30Tablets
【原产地英文药品名】SITAGLIPTIN
【中文参考商品译名】
注:以下产品不同规格和不同价格,购买时请以电话咨询为准
·Januvia10毫克x30片/瓶
·Januvia 25毫克x30片/瓶
·Januvia 50毫克x30片/瓶
【中文参考药品译名】SITAGLIPTIN
【中文参考化合物名称】二肽酰肽酶4(DPP-4)抑制剂类
【生产厂家中文参考译名】美国默克制药
【生产厂家英文名】Merck & Co., Inc.

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