普利一般是用于治疗高血压，心脏衰竭，和其他心脏问题。它可单独使用或与其他药物。它也可用于其他条件所确定的你的医生。依那普利是一种血管紧张素转换酶（ ACE ）抑制剂。它的工作原理是帮助放松血管。这有助于降低血压.  Vasotec Generic Drugs: Not to use Enalapril if: you are allergic to any ingredient in Enalapril or similar medicines (eg, captopril, lisinopril) you are pregnant you are taking dextran sulfate or a potassium-sparing diuretic (eg, amiloride) Contact your doctor or health care provider right away if any of these apply to you. Before using Enalapril : Some medical conditions may interact with Enalapril . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have or have ever had liver or kidney problems or kidney transplantation if you are receiving dialysis if you have bone marrow suppression, low blood counts, low blood sodium, high blood potassium, the blood disease porphyria, giant hives, systemic lupus erythematosus (SLE or lupus), scleroderma, or a collagen vascular disease if you have narrowing or hardening of the arteries of the brain or heart, chest pain, or discomfort known as angina Some MEDICINES MAY INTERACT with Enalapril . Tell your health care provider if you are taking any other medicines, especially any of the following: Diuretics (eg, furosemide, hydrochlorothiazide) because excessive decreases in blood pressure may occur, which may cause dizziness, especially upon standing, or fainting Dextran sulfate because it may increase the risk of allergic reaction (eg, rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) and lightheadedness upon standing Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, aspirin, indomethacin) because they may decrease Enalapril 's effectiveness and the risk of kidney damage may be increased Lithium or thiopurines (eg, azathioprine) because the risk of serious side effects may be increased by Enalapril Oral diabetes medicine (eg, glyburide) because side effects, including a low blood sugar level (eg, dizziness, headache, hunger, shakiness or weakness, sweating), may be increased by Enalapril Potassium-sparing diuretics (eg, amiloride) or potassium supplements may cause high blood potassium levels (eg, abnormal skin sensations of the arms and legs, confusion, heaviness of the limbs, listlessness, slow or irregular heartbeat, stopping of the heart) when used with Enalapril This may not be a complete list of all interactions that may occur. Ask your health care provider if Enalapril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. How to use Enalapril : Use Enalapril as directed by your doctor. Check the label on the medicine for exact dosing instructions. Take Enalapril by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. If you miss a dose of Enalapril , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use Enalapril . Important safety information: Enalapril may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Enalapril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Check with your doctor before you use a salt substitute or a product that has potassium in it. If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms. Enalapril may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse. Enalapril may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Enalapril . Use a sunscreen or wear protective clothing if you must be outside for more than a short time. Tell your doctor or dentist that you take Enalapril before you receive any medical or dental care, emergency care, or surgery. Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Enalapril . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Enalapril should not be used in NEWBORNS; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: Enalapril may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Enalapril is found in breast milk. If you are or will be breast-feeding while you use Enalapril , check with your doctor. Discuss any possible risks to your baby. Possible side effects of Enalapril : All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Diarrhea; dizziness or lightheadedness when sitting up or standing; headache; nausea; persistent, dry cough; tiredness; vomiting. Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; hoarseness; infection (eg, fever, sore throat); irregular or slow heartbeat; unusual stomach pain; yellowing of the skin or eyes. This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. If OVERDOSE is suspected: Contact your local poison control center or emergency room immediately. Symptoms may include dizziness; lightheadedness, especially upon standing; weakness. Proper storage of Enalapril : Store Enalapril at room temperature below 86 degrees (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Enalapril out of the reach of children and away from pets. General information: If you have any questions about Enalapril , please talk with your doctor, pharmacist, or other health care provider. Enalapril is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. 药物名称：依那普利 英文名称：Enalapril 中文别名: 益压利，恩纳普利，伊那普利，依纳普利，灵广俐, 苯丙脯酸，苯丁脂脯酸，苯丁酯脯酸，苯脂丙脯酸，苯酯丙脯酸，依拉普利，依那林 英文别名: Enalaprilum，Enam，Innovace，Inovoril，Mk-421，Vasotec，Mkozl，Vascare 规格 依那普利片 2.5mg; 5mg; 10mg; 20mg 药理作用 本品为血管紧张素转换酶抑制剂。口服后在体内水解成依那普利拉(Enalaprilat)，后者强烈抑制血管紧张素转换酶，降低血管紧张素Ⅱ含量，造成全身血管舒张，引起降压。本品对Ⅱ肾型高血压、Ⅰ肾型高血压及原发性高血压大鼠模型均有明显降压作用。 药动学 依那普利是前体药物，其乙酯部分在肝内被迅速水解，转化成它的有效代谢产物--依那普利拉来发挥降压作用。口服依那普利约68%被吸收，与食物同服不影响生物利用度。服药后1小时，血浆依那普利浓度可达峰值。服药后3.5～4.5小时，依那普利拉血浆浓度可达峰值，半衰期为11小时。肝功能异常者依那普利转变成依那普利拉的速度延缓，依那普利给药20分钟后广泛分布于全身，肝、肾、胃和小肠药物浓度最高，大脑中浓度最低。一日口服2次，两天后，依那普利拉与血管紧张素转换酶结合达到稳态，最终半衰期延长为30～35小时，依那普利拉主要由肾脏排泄。严重肾功能不全病人(肌酐清除率低于30ml/min)可出现药物蓄积，本药能用血液透析法清除。 适应症 用于治疗原发性高血压。 用法用量 口服。开始剂量为一日5mg～10mg，分1～2次服，肾功能严重受损病人(肌酐清除率低于30ml/min)为一日2.5mg。根据血压水平，可逐渐增加剂量。一般有效剂量为一日10～20mg，每日最大剂量一般不宜超过40mg，可与其他降压药特别是利尿剂合用，降压作用明显增强，但不宜与潴钾利尿剂合用。 任何疑问，请遵医嘱！ 不良反应 可有头昏、头痛、嗜睡、口干、疲劳、上腹不适、恶心、胸闷、咳嗽、蛋白尿、皮疹、面红等。必要时减量。如出现白细胞减少，需停药。 注意事项 1．个别病人，尤其是在应用利尿剂或血容量减少者，可能会引起血压过度下降，故首次剂量宜从2.5mg开始。 2．定期作白细胞计数和肾功能及血钾测定。 3．对本品过敏者或双侧性肾动脉狭窄患者忌用。孕妇、哺乳期妇女、儿童、肾功能严重受损者慎用。