【药品名称】阿尼西坦片 |
【通用名称】阿尼西坦片 |
【生产企业】山西亚宝药业集团股份有限公司 |
【产品规格】50mg |
【产品单位】盒 |
【零售价格】25.80元 |
【药物名称】阿尼西坦片 【英文名】Aniracetam Tablets 【汉语拼音】Anixitan Pian 【主要成分】阿尼西坦 【性状】白色片 【药理作用】通过血脑屏障选择性作用于中枢神经系统。动物实验证明:对正常大鼠辨别学习的记忆再现过程有良好的促进作用,能对抗缺氧引起的记忆减退,能有效改善某些原因引起的记忆障碍。 【药代动力学】文献报道,大鼠口服后吸收迅速,20~40分钟血药浓度达峰值。主要分布在胃肠道、肾、肝、脑和血液。24小时后,77~85%由尿中排出,4%从粪便中排出。尿中主要代谢产物为N-对甲氧基苯甲酰氨基丁酸和5-羟基-2-吡咯烷酮。 人体研究:口服吸收后,血中原药消除半衰期平均20~30分钟,2小时后血药浓度已难测出。 【适应症】脑功能改善药。中老年记忆减退,脑血管病后记忆减退。 【用法与用量】口服。一次0.1~0.2g,一日3次,疗程4~8周。 【不良反应】较安全,偶有轻微口干、厌食、嗜睡、头昏、便秘、停药后消失。 【禁忌症】过敏者禁用。 【注意事项】建议安全使用范围一日0.3~1.8g。 【规格】50mg。 【贮藏】遮光、密闭保存。 【有效期】暂定3年。
【批准文号】国药准字H20000548 【生产厂商】山西亚宝药业集团股份有限公司
Aniracetam (Ampamet)
Aniracetam - brand name Ampamet is the first Nootropic analogue developed from Piracetam It is virtually non-toxic and has beneficial effects in the treatment of memory loss, age related memory decline and lack of concentration. Aniracetam can improve memory recall, reaction, and detail. In tests, Aniracetam has proven to be one of the most potent nootropics currently available, this is because of its ability to protect AMPA brain receptors and nerve cells.
Aniracetam facilitates communication within the brain, improving the speed and operation of the mind
Numerous tests have proven that Aniracetam is one of the most potent nootropics, or ‘smart drugs’, currently available. Nootropic is the term used to describe drugs that act on the mind. The term was first used by Dr. Giurgea to describe a substance that was found to have beneficial effects in the treatment of memory loss, age related memory decline and lack of concentration.
Aniracetam is an analogue of Piracetam, purported to improve memory recall, reaction and detail. Like many of Piracetam's analogues, less Aniracetam is required (milligram dose per pound of body weight). But like Piracetam, Aniracetam has been found to be virtually non-toxic, with very few side effects and contraindications. Compared to Piracetam, Aniracetam has a more potent AMPA receptor enhancing effect, resulting in better focus and concentration.
One of the primary differences between nootropics and other 'memory enhancers’ is that nootropics improve communication across the brain's Corpus Callosum, the area of the brain that joins the left and right hemispheres. This cross-brain communication links the logical side of the brain with the creative side of the brain, allowing the user to draw on a greater potential of their mental ability.
Aniracetam is also considered to be a drug that can modulate the brain acetylcholine system. Findings show that Aniracetam administration significantly improves the cognitive function of patients with senile dementia of the Alzheimer type. The most likely explanation for this is that regular doses of Aniracetam has made a positive impact on the brain’s memory mechanism.
It also has a beneficial affect on the body as a whole, with improvements shown in users’ immune systems, increasing resistance to infection and generating a feeling of health and well-being, particularly in the elderly.
Another of Aniracetam's interesting properties is that its effects are very short-lived. After oral administration, the onset of activity is rapid and the total duration of activity is short. In rats, peak plasma levels of Aniracetam are reached 20-30 minutes after oral administration, and the half-life is 1.7-2.1 hours. In humans, the highest blood levels of the metabolites are reached two hours after administration, and this coincides with the largest changes in the EEG. Plasma levels of the metabolites reach baseline within 6 hours, although the half-life and AUC are both significantly increased in the elderly.
Like Piracetam, the dose-response curve for Aniracetam is bell-shaped. In rodents, effective doses are usually in the 10-100 mg/kg range, while the dose of Piracetam used in most rodent studies falls in the 100-600 mg/kg range. Also like Piracetam, a lower dose is required in primates to exert the same effect. The commonly recommended dose for clinical use is 1500 mg daily. A study comparing oral administration of 12.5, 25, and 50 mg/kg to monkeys found that all of the doses improved performance on a match-to-sample task, but the greatest effect was found at 25 mg/kg. In a study in the elderly, 1000 mg exerted greater EEG changes than 250 and 500 mg, as well as 2000 mg of Piracetam. The commonly recommended dose for nootropic use is 750-1500 mg, and this information supports that dosage range. Because of the short duration of activity, it would be ideal to take Aniracetam multiple times during the day. |