药品名称
商品名: 百优解Prozac （原名 ：百忧解）
通用名: 盐酸氟西汀胶囊
性状: 盐酸氟西汀的化学名称为(±)-N-甲基-3-苯基-3-[(α、α、α -三氟-P-甲苯基)-氧代]丙胺盐酸盐。
分子式：C17H18F3NO•HCL
分子量：345.79
规格
胶囊10mg, 20mg, 40mg; 口服液20mg/5ml X 120ml.
药理作用
氟西汀是神经元摄取5－羟色胺的选择性抑制剂，它的抗抑郁活性证实是与抑制神经元摄取5－羟色胺的能力有直接关系。
病人如有肝损伤可影响百优解的消除。
严重肾损伤病人可导致百优解或其所有代谢物的进一步蓄积。
药代动力学
口服氟西汀单次剂量后6－8小时血药浓度达峰。饭后服用百优解不影响药物的吸收量。
 
适应症
百优解适用于抑郁症及其伴发之焦虑的治疗。也可用于治疗神经性贪食症和强迫性障碍。
用法用量
抑郁症
建议起始剂量为晨服20 mg。如果经数周治疗后，临床症状没有改善，可考虑增加剂量，逐渐增加剂量，比如改为1天2次，早、午各服20 mg。
神经性贪食症
建议治疗剂量为每天60 mg。
强迫性障碍
建议治疗剂量为每天20-60 mg。
以上任何状况下治疗剂量均不能超过每天80 mg。
老年患者
建议治疗剂量为每天20 mg。
肝功能损伤患者－用量和频度均应减少。
肾功能损伤患者－用量和频度均应减少。氟西汀为口服用药。片剂可溶于一杯水中或直接吞服。

任何疑问, 请遵医嘱!

不良反应

与使用氟西汀有关的最常见的不良反应为：焦虑、紧张、失眠、困倦、疲劳、震颤、多汗、厌食、恶心、腹泻、头晕。
不太常见的反应为：头痛、口干、消化不良、呕吐。
其它严重的不良反应偶见报道，例如晕厥、心律失常、非正常肝反应、甲状腺功能减退或亢 进、出血时间延长、急性脑部综合征和惊厥。
禁忌症

禁用于对百优解和/或百优解中任何成分过敏的病人。
 
警告

某些患有与氟西汀有关的皮疹的病人，曾经发展为严重的认为与脉管炎有关的全身反应。与此有关的非常偶然的致命事件也有报道。如发生皮疹或其它任何明显的未知病因的过敏症状均应立即停药。
 
注意事项

据报道，部分病人应用氟西汀后可出现躁狂/轻躁狂。
对驾驶的影响：对操作危险机械包括机动车的病人应予以警告，直至他们确认药物对他们不产生有害的影响为止。

孕妇及哺乳期妇女用药

使用氟西汀的安全性还未研究。因此，妊娠期妇女除非必要，否则禁用此药。
百优解可从母乳中分泌，因此授乳期妇女慎用百优解。
 
儿童用药

由于缺乏百优解应用于儿童的经验资料，故不宜用于儿童。

老年患者用药

临床研究未发现与年龄有关的不良现象产生。
 
药物相互作用

百优解偶尔可增加其它抗抑郁药的血药水平。 据报道，糖尿病人在应用百优解治疗期间有可能出现低血糖症，中断治疗后有可能出现高血糖症。应适当调整胰岛素用量和/或口服降血糖药。
百优解与单胺氧化酶抑制剂（MAOI）不能同时服用，也不能在中断MAOI治疗后14日内使用。中断氟西汀治疗和应用MAOI治疗的间隔期限应严格遵守5周的时间。
药物过量

征兆或症状
－主要为恶心和呕吐。可能出现其它中枢神经兴奋的征兆如激动或抽搐。自上市以来，由于单独服用氟西汀过量所致的死亡病例极端罕见。
治疗
－建议进行对症治疗和支持治疗。服用活性炭与催吐或洗胃一样有效甚至更有效。因氟西汀导致的惊厥发作如不能自行缓解，可用地西泮进行治疗。
在氟西汀与其它抗抑郁药共同服用过量时，应格外小心。

英文药名: Prozac (Fluoxetine capsules)

中文药名: 百忧解（氟西汀胶囊）

生产厂家: Eli Lilly

Important Warning about Antidepressant Use from the FDA

【原产地英文商品名】FLUOX(Romanian PROZAC) 20mg/cap 28caps/box
【原产地英文药品名】FLUOXETINE
【中文参考商品译名】
注：以下产品不同的规格和不同的价格，购买时请咨询为准
·FLUOX(罗马尼亚百优解) 20毫克/胶囊 28胶囊/盒
·FLUOX(新西兰百优解) 20毫克/胶囊 28胶囊/盒
·盐酸氟西汀片剂(百优解仿制药) 20毫克/片 30片/盒
·盐酸氟西汀片剂(百优解仿制药) 10毫克/片 30片/盒
·盐酸氟西汀胶囊(百优解仿制药) 40毫克/胶囊 30胶囊/盒
·盐酸氟西汀胶囊(百优解仿制药) 10毫克/胶囊 30胶囊/盒
·氟西汀DR胶囊(百优解仿制药) 90毫克/胶囊 4胶囊/盒
·氟西汀(百优解仿制药) 20毫克/胶囊 30胶囊/盒
【中文参考药品译名】氟西汀
【生产厂家中文参考译名】Pacific Pharmaceuticals Ltd
【生产厂家英文名】Pacific Pharmaceuticals Ltd

Fluoxetine Uses
Fluoxetine 20mg 40mg Capsules are used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), some eating disorders, and panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks). Fluoxetine is also used to relieve the symptoms of premenstrual dysphoric disorder, including mood swings, irritability, bloating, and breast tenderness. Fluoxetine is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). They work by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.
Dosage
Depression in adults is treated with 20-80mg of fluoxetine daily. After 13 weeks of daily administration, once weekly dosing may be effective in some patients. Bulimia is treated with 60mg of fluoxetine daily. Long-term treatment for up to 52 weeks has been shown to be beneficial in maintaining remission. Obsessive-compulsive disorder in adults is treated with 20-60mg daily and panic disorder is managed with 10-60mg daily. The recommended regimen for PMDD is 20mg administered every day of the menstrual cycle or daily for 14 days prior to the onset of menstruation through the first day of menses.
Fluoxetine Precautions
Before taking fluoxetine, tell your doctor and pharmacist if you are allergic to fluoxetine or any other medications. Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking fluoxetine, call your doctor. You should know that fluoxetine may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you. remember that alcohol can add to the drowsiness caused by this medication.
Fluoxetine Side Effects
Fluoxetine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nervousness, nausea, dry mouth, sore throat, drowsiness, weakness, uncontrollable shaking of a part of the body, loss of appetite, weight loss, changes in sex drive or ability or excessive sweating. Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately: rash, hives, fever, joint pain, swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs, difficulty breathing or swallowing, seeing things or hearing voices that do not exist (hallucinating), seizures. Fluoxetine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Fluoxetine Drug Interactions
Fluoxetine should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants [for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane)] or other drugs that inhibit monoamine oxidase [for example, linezolid (Zyvox)]. Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. Administration of fluoxetine and MAOIs should be separated by 14 days. Similar reactions occur when fluoxetine is combined with other drugs [for example, tryptophan, St. John's wort, meperidine (Demerol), tramadol (Ultram)] that increase serotonin in the brain. Fluoxetine may increase the effect of warfarin (Coumadin), leading to excessive bleeding. Warfarin therapy should be monitored more frequently in patients who are also taking fluoxetine. Combining SSRIs with aspirin, nonsteroidal anti-inflammatory drugs or other drugs that affect bleeding may increase the likelihood of upper gastrointestinal bleeding.

Missed Dose
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one

Fluoxetine Overdose
In case of overdose, call your local poison control center on 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services on 911.

Symptoms of overdose may include: unsteadiness, confusion, unresponsiveness, nervousness, uncontrollable shaking of a part of the body, dizziness, rapid, irregular or pounding heartbeat, seeing things or hearing voices that do not exist (hallucinating), fever, fainting or coma (loss of consciousness for a period of time)