What Sandomigran is used for
Sandomigran is used to prevent vascular headaches, including migraine, cluster headaches and vasomotor headaches.
Vascular headaches are thought to be caused by temporary changes in the size of small blood vessels in the brain. These changes cause the pain and problems with vision that often happen during a severe headache. Sandomigran prevents an attack by stopping the blood vessels from changing in size.
Sandomigran is only used to prevent severe headaches from happening. It will not stop an attack once it has started.
Ask your doctor if you have any questions about why this medicine has been prescribed for you.
Your doctor may have prescribed it for another reason.
Sandomigran is only available with a doctor's prescription. It is not addictive.
There is not enough information to recommend this medicine for children.
 
Before you take Sandomigran
When you must not take it
Do not take Sandomigran if you have an allergy to pizotifen (the active ingredient) or to any of the other ingredients of Sandomigran listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin.
Do not take Sandomigran after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
In that case, return it to your pharmacist.
Before you start to take it
Tell your doctor if you have any of the following medical conditions:
• increased pressure in the eye due to glaucoma
• difficulty in passing urine (water), due to prostate trouble or any other cause
Your doctor may want to take special precautions if you have one of the above conditions.
Tell your doctor if you are pregnant or intend to become pregnant.
Experience with Sandomigran in pregnancy is very limited. If it is necessary for you to take this medicine during pregnancy, your doctor will discuss with you the benefits and risks involved.
Tell your doctor if you are breast-feeding or intend to breast-feed.
Small amounts of Sandomigran pass into breast milk. Although such small amounts are unlikely to harm your baby, breast-feeding while taking this medicine is not recommended. Your doctor will discuss with you the benefits and risks involved.
Tell your doctor if you are lactose intolerant.
This medicine contains lactose.
Tell your doctor if you have allergies to any other medicines, foods, dyes or preservatives.
Your doctor will want to know if you are prone to allergies.
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines and Sandomigran may interfere with each other. These include:
• medicines to calm you down or help you sleep
• antihistamines, found in cough, cold and allergy medicines
• Monoamine oxidase inhibitors (MAOI) which belong to a group of medicines called antidepressants
These medicines may worsen the drowsiness that sometimes happens when you take Sandomigran. You may need to take different amounts of your medicines or you may need to take different medicines. Your doctor and pharmacist have more information.
If you have not told your doctor about any of these things, tell him/her before you start taking this medicine.

How to take Sandomigran
Follow all directions given to you by your doctor and pharmacist carefully.
These instructions may differ from the information contained in this leaflet.
If you do not understand the instructions on the label, ask your doctor or pharmacist for help.
How much to take
The usual starting dose is one tablet of Sandomigran each day. To avoid making you drowsy, the dose is gradually increased, usually to three tablets each day.
If your headaches are still not controlled, your doctor may gradually increase the dose up to a maximum of nine tablets each day, divided into two or three doses.
When to take it
Your doctor may tell you to take all of the tablets at one time (usually at night) or he/she may tell you to divide the tablets over the day (for example, 1 tablet in the morning and 2 tablets at night).
How to take it
Take the tablets with a full glass of water.
They can be taken with or without food.
Try to take the tablets at about the same times each day.
Taking them at the same times each day will help you to remember to take them.
How long to take it
Continue taking Sandomigran every day for as long as your doctor prescribes.
To prevent severe headaches, you must take this medicine every day, even if you feel well.
If you forget to take it
If it is almost time for your next dose, skip the dose you missed and take the next dose when you are meant to.
Otherwise, take it as soon as you remember, and then go back to taking it as you would normally.
Do not take a double dose to make up for the one that you missed.
This may increase the chance of you getting an unwanted side effect.
If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.
If you take too much (Overdose)
Immediately telephone your doctor or the Poisons Information Centre (telephone number 13 11 26), or go to Accident and Emergency at your nearest hospital if you think that you or anyone else may have taken too much Sandomigran. Do this even if there are no signs of discomfort or poisoning. Keep the telephone numbers for these places handy.
Some of the symptoms of an overdose may include drowsiness, nausea (feeling sick), dizziness or lightheadedness, slow breathing, coma, and convulsions (particularly in children). Children may also become overexcited.

While you are taking Sandomigran
Things you must do
If you become pregnant while taking Sandomigran, tell your doctor.
Your doctor can discuss with you the risks of taking it while you are pregnant.
If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking Sandomigran.
Tell any other doctor, dentist or pharmacist who treats you that you are taking Sandomigran.
Things you must not do
Do not take Sandomigran to treat a severe headache once it has started.
This medicine is only used to prevent severe headaches. It will not stop an attack once it has started.
Do not give this medicine to anyone else, even if their condition seems similar to yours.
Do not take it to treat any other complaints unless your doctor tells you to.
This medicine is not appropriate for common 'tension' headaches.
Things to be careful of
Be careful driving, operating machinery or doing jobs that require you to be alert until you know how Sandomigran affects you.
This medicine may make you feel drowsy, especially when you first start to take it. If that happens, do not drive or do anything else that could be dangerous.
Be careful when drinking alcohol while you are taking Sandomigran.
The combination could make you feel drowsier than usual.

Side effects
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Sandomigran.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by these lists of possible side effects. You may not experience any of them. Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor as soon as possible if you notice any of the following:
• signs of fluid buildup such as swelling of the ankles, feet or lower legs
• faintness, dizziness or lightheadedness
• numbness or tingling feeling in arms or legs
• skin rash
• seeing, feeling or hearing things that are not there (hallucinations)
• signs of an allergic reaction such as swelling of the face or itchy skin
Tell your doctor if you notice any of the following and they worry you:
• drowsiness
• fatigue
• dry mouth
• nausea (feeling sick)
• constipation
• aching muscles
• increased appetite, weight gain
• problems with sexual function
• problems sleeping
• a feeling of deep sadness, anxiety or sudden mood changes
Tell your doctor if you notice anything else that is making you feel unwell.
Some people may have other side effects not yet known or mentioned in this leaflet.

After taking Sandomigran
Storage
• Keep your medicine in the original container until it is time to take it.
• Store it in a cool dry place.
• Do not store Sandomigran or any other medicine in the bathroom or near a sink.
• Do not leave it in the car or on window sills.
Keep the medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
Disposal
If your doctor tells you to stop taking this medicine or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

【製造会社---サンドミグラン / Sandomigran】
Novartis（イタリア）
【配合成分---サンドミグラン / Sandomigran】
Pizotifen Hydrogen Malate 0.5mg

【説明---サンドミグラン / Sandomigran】
Sandomigran（サンドミグラン）は、Pizotifen Hydrogen Malate（ピゾチフェン）が成分です。海外では片頭痛、血管性頭痛、群発性頭痛（ホートン症候群）のような再発性の頭痛や偏頭痛の治療に用いられています。
※既に起こっている片頭痛等には効果がありません。
～　ご注意事項　～

◆医薬品は必ずご注意事項および用法容量を守ってください。
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◆当方はお客様の個人輸入代行手続きを行っております。
◆個人輸入代行商品を確実にお届けすることが責任範囲となります。
◆個人輸入された医薬品は『医薬品副作用被害救済制度』の救済対象となりません。
◆医薬品の輸入規定量は個人でご判断下さい。
◆薬監証明が必要な量の場合にはあらかじめ必要な書類の準備を行っておいて下さい。
◆『主治医の指導を受けていない人』『薬剤知識に不安がある人』『英語の使用説明書に不安がある人』は大変危険ですので医薬品の個人輸入はなさらないで下さい。
We are not intended to provide specific advice for you.
◆ジェネリック選択基準は現地の総合病院・クリニック等でよく処方されている中から主任薬剤師が選択しております。
◆現地政府によって正式に認可されていないまたは特許の切れていない、ジェネリックはお取り扱い出来ません。
You should carefully read all English information provided by the manufacturers on or in the product packing and lebels before using any the product.
ALWAYS CONSULT YOUR OWN PHYSICIAN OR DOCTOR FOR ADVICE AND TREATMENT.
◆通常カプセルタイプの医薬品は「HALAL」「Vagetarian」の証明を受けておりません。
Generally our drugs are not Halal or Vegirarian certified but most supplements are certified.
The reason is when they use vegetable capsules, the capsule is not very stable and this may cause the medicine to get spoil.
◆錠剤タイプに関しましては「Muslim」「Hindu」「Vagetarianism」の方が服用しても大丈夫かどうかお調べいたします。また、代替品についてもお調べいたします。
We will ask our pharmacists or doctors about tablets for Muslim, Hindu or Vegitarianism people and also check alternative drugs.