英文药名: Mobic (Meloxicam Tablets)

中文药名: 莫比可（美洛昔康片）

生产厂家: Boehringer Ingelheim

美洛昔康( Meloxicam )

化学名：4-羟基-2-甲基-N-(5-甲基-1,3-噻唑-2-基)-2H-1,2-苯并噻嗪-3-羧酸乙酯 1,1-二氧化物

类别：美洛昔康是非甾体抗炎药，用来减轻一些关节炎的症状，治疗风湿药

适应症：使用于类风湿性关节炎的症状治疗，疼痛性骨关节炎（关节病、退行性骨关节病）的症状治疗。

用法用量：口服，用水或流质送服吞咽。 　　
类风湿性关节炎：每天15mg（2片），根据治疗后反应，剂量可减至一日7.5mg（1片）。 　　
骨关节炎：一日7.5mg（1片），如果需要，剂量可增值一日15mg（2片）。 　　
对于不良反应有可能增加的病人：治疗开始剂量一日7.5mg(1片)。 　　
严重肾衰竭的病人透析时：剂量不应超过一日7.5mg（1片）。 　　
本品每日最大建议剂量为15mg(2片)。 　　
儿童适用的剂量尚未确定，目前只限于成人使用。

不良反应
根据国外研究资料报道，以下罗列的不良反应系在本品给药后发生，然而他们的发生频率是根据临床实验记录结果，而无论与本品用药是否有因果关系。这些信息是基于对3750个病人进行的超过18个月的临床实验得到的，病人每日口服本品剂量为7.5或15毫克。（治疗用药的平均时间为127天）。 　　
1、胃肠道：频率超过1％：消化不良、恶心、呕吐、腹痛、便秘、胀气、腹泻。频率介于0.1％和1％之间：短暂的肝功能指标异常（如转氨酶或胆红素升高）。食道炎、胃十二指肠溃疡，隐伏或肉眼可见的胃肠道出血。频率小于0.1％：胃肠道穿孔，结肠炎。 　　
2、血液：频率超过1％：贫血。介于0.1％和1％之间：血细胞计数失调，包括白细胞分类计数，白细胞减少和血小板减少，同时使用潜在的骨髓毒性药物，特别是氨甲喋呤，是导致出现血细胞减少的一个因素。 　　
3、皮肤：频率超过1％：瘙样、皮疹。介于0.1％和1％之间：口炎、寻麻疹。少于0.1％：感光过敏。 　　
4 、呼吸道：频率少于0.1％：已有报道在使用阿斯匹林或其他NSAID，包括本品之后有个体出现急性哮喘。 　　
5、中枢神经系统：频率多于1％：轻微头晕、头痛。介于0.1％和1％：眩晕、耳鸣、嗜睡。 　　
6、心血管：频率多于1％：水肿。介于0.1％和1％之间：血压升高、心悸、潮红。 　　
7、泌尿系统：介于0.1％和1％之间：肾功能指标异常（血清肌酐和／或血清尿素升高）。

禁忌
以下情况禁用：对药物活性成分美洛昔康或其赋形剂已知过敏者。与乙酰水杨酸和其他NSAID可能会有交叉过敏反应。对使用乙酰水杨酸或其他NSAID后出现哮喘、鼻腔息肉、血管水肿或寻麻疹等症状的病人不宜使用本品。活动性消化性溃疡，严重肝功能不全者，非透析严重肾功能不全者，儿童和年龄小于15岁的青少年，孕妇或哺乳者。 　

【孕妇及哺乳期妇女用药】虽然在临床前的试验中没有发现致畸作用，但本品不应用于孕妇和哺乳者。 　　
【儿童用药】儿童的适用剂量尚未确定，儿童和年龄小于15岁的青少年禁用。 　　
【老年用药】对可能有肝、肾及心功能不全的老年患者应慎用。

药物过量：因为没有已知的解毒药，所以在过剂量情况时应采取胃排空及支持疗法。有临床试验表明消胆胺可促进本品的排泄。

贮藏：遮光、密封保存。放在儿童伸手不及处。

Mobic
Generic Name: meloxicam (mel OKS i kam)
Brand Names: Mobic

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What is Mobic?
Mobic is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Mobic works by reducing hormones that cause inflammation and pain in the body.

Mobic is used to treat pain or inflammation caused by arthritis.

Mobic may also be used for other purposes not listed in this medication guide.

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What is the most important information I should know about Mobic?
This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking Mobic. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

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What should I discuss with my healthcare provider before taking Mobic?
Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Do not use Mobic if you are allergic to meloxicam, or to aspirin or other NSAIDs.

Before taking Mobic, tell your doctor if you are allergic to any drugs, or if you have:
a history of heart attack, stroke, or blood clot;
heart disease, congestive heart failure, high blood pressure;
a history of stomach ulcers or bleeding, bowel problems, diverticulosis;
liver or kidney disease;
asthma;
polyps in your nose; or
if you smoke.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Mobic.

FDA pregnancy category C. Mobic may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking Mobic during the last 3 months of pregnancy may harm the unborn baby. Do not take Mobic during pregnancy unless your doctor has told you to. Mobic can pass into breast milk and may harm a nursing baby. Do not use Mobic without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 2 years old without the advice of a doctor.

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How should I take Mobic?
Take Mobic exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. The maximum amount of Mobic for adults is 15 milligrams (mg) per day. Know the amount of Mobic in the specific product you are taking.

If you take Mobic for a long period of time, your doctor may want to check you on a regular basis to make sure Mobic is not causing harmful effects. Do not miss any scheduled appointments.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using Mobic.

Store Mobic at room temperature, away from moisture, heat, and light.

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What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, dizziness, drowsiness, black or bloody stools, coughing up blood, fever, urinating less than usual or not at all, shallow breathing, fainting, seizure (convulsions), or coma.

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What should I avoid while taking Mobic?
Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain medicines similar to Mobic (such as aspirin, ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking Mobic. Alcohol can increase the risk of stomach bleeding.

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Mobic side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Mobic and seek medical attention or call your doctor at once if you have any of these serious side effects:
chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
urinating less than usual or not at all;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
bruising, severe tingling, numbness, pain, muscle weakness.

Less serious side effects may include:
upset stomach, mild heartburn or stomach pain, diarrhea, constipation; bloating, gas;
dizziness, headache, nervousness, mood changes;
skin itching or rash;
dry mouth;
increased sweating, runny nose;
blurred vision; or
ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

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What other drugs will affect Mobic?
Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with Mobic may cause you to bruise or bleed easily.

Before taking Mobic, tell your doctor if you are taking any of the following drugs:
cyclosporine (Gengraf, Neoral, Sandimmune);
lithium (Eskalith, Lithobid);
diuretics (water pills) such as furosemide (Lasix);
glyburide (DiaBeta, Micronase);
methotrexate (Rheumatrex, Trexall);
a blood thinner such as warfarin (Coumadin);
steroids (prednisone and others);
an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik); or
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Voltaren), etodolac (Lodine), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen (Orudis), naproxen (Aleve, Naprosyn), and others.

This list is not complete and there may be other drugs that can interact with Mobic. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Where can I get more information?
Your pharmacist can provide more information about Mobic.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

【原产地英文商品名】:MOBIC ORAL SUSPENSION 7.5mg/5ml 100mls/bottle
【原产地英文药品名】:MELOXICAM
【中文参考商品译名】:MOBIC口服混悬剂 7.5毫克/5毫升 100毫升/瓶
【中文参考药品译名】:美洛昔康
【生产厂家中文参考译名】:勃林格殷格翰
【生产厂家英文名】:BOEHRINGER INGELHEIM