【药物名称】头孢唑肟
【药物别名】头孢去甲噻肟，CEFTIZOX
【英文名称】Ceftizoxime
说明：注射用头孢唑肟钠：每瓶0.5g；1g
【功用作用】
抗菌谱与头孢噻肟近似，对一些革兰阳性菌有中度的抗菌作用，对革兰阴性菌的作用强，主要敏感菌有金黄色葡萄球菌、链球菌、肺炎链球菌、嗜血杆菌属、奈瑟菌、大肠杆菌、肺炎克雷白杆菌、沙雷杆菌、枸橼酸杆菌、各型变形杆菌、伤寒杆菌、痢疾杆菌、消化链球菌、消化球菌、梭状芽胞杆菌等。 耐第一代头孢菌素和庆大霉素的一些革兰阴性菌可对本品敏感。但粪链球菌和耐甲氧西林的葡萄球菌对本品不敏感。 　　
本品口服不吸收。静注0.5g后5分钟，血药浓度为59μg／ml，30分钟时约为25μg／ml，有效血药浓度约可维持4小时。 在体内几不代谢，主要由尿液排出。静注1g后8小时，尿药浓度尚可达30μg／ml，在体内分布广，可渗入各种体液中，也可渗入脑脊液中。本品的t1/2约为1.2小时。 　　
临床应用于敏感菌所致的肺炎、支气管炎、胸膜炎、腹膜炎，以及皮肤和软组织、尿路、胆道、骨和关节、五官、创面、前列腺等部位的感染，也用于败血症和脑膜炎。
【用法用量】1日剂量为0.5～2g，重症可用到4g，分为2～4次给予。肌注溶媒为灭菌注射用水或0.5％利多卡因注射液，静注溶媒为灭菌注射用水、等渗氯化钠注射液或葡萄糖注射液。如需静滴则可溶于注射用水后再加入输液中，控制滴入时间1／2～2小时。 
【注意事项】
（1)除产生过敏、腹泻、恶心、呕吐、药物热等头孢菌素所共有的不良反应外，还有一时性的眩晕和头痛反应发生。 　　
（2)本品皮试液的浓度为300μg／ml。

【原产地英文商品名】CEFTIZOX 1g/vial
【原产地英文药品名】CEFTIZOXIME
【中文参考商品译名】CEFTIZOX 1克/瓶
【中文参考药品译名】头孢唑肟
【生产厂家中文参考译名】葛兰素史克
【生产厂家英文名】Glaxo Smith Kline

Cefizox
Generic Name: Ceftizoxime (SEFF-tih-ZOX-eem)
Brand Name: Cefizox

--------------------------------------------------------------
Cefizox is used for:
Treating serious infections caused by certain bacteria.

Cefizox is a cephalosporin antibiotic. It works by interfering with the formation of the bacteria's cell wall so that the wall ruptures, resulting in the death of the bacteria.

--------------------------------------------------------------
Do NOT use Cefizox if:
you are allergic to any ingredient in Cefizox or any other cephalosporin antibiotic (eg, cephalexin, cefprozil)

Contact your doctor or health care provider right away if any of these apply to you.
--------------------------------------------------------------
Before using Cefizox:
Some medical conditions may interact with Cefizox. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have diarrhea, a stomach or intestinal infection, or a blood clotting problem
if you have had a severe allergic reaction (eg, a severe rash, hives, breathing difficulties, dizziness) to a penicillin antibiotic (eg, amoxicillin) or other beta-lactam antibiotic (eg, imipenem)

Some MEDICINES MAY INTERACT with Cefizox. Tell your health care provider if you are taking any other medicines, especially any of the following:
Aminoglycosides (eg, gentamicin) because side effects, such as kidney toxicity, may be increased by Cefizox

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cefizox may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

--------------------------------------------------------------
How to use Cefizox:
Use Cefizox as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Cefizox is usually administered as an injection at your doctor's office, hospital, or clinic.
If you are using Cefizox at home, carefully follow the injection procedures taught to you by your health care provider.
If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
Cefizox works best when taken at the same time(s) each day.
To clear up your infection completely, continue using Cefizox for the full course of treatment even if you feel better in a few days. Do not miss any doses.
Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
If you miss a dose of Cefizox, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cefizox.

--------------------------------------------------------------
Important safety information:
If severe diarrhea, stomach pain/cramps, or bloody stools occur, contact your doctor at once. This could be a symptom of a serious side effect requiring immediate medical attention. Do not treat diarrhea without consulting your doctor.
Cefizox is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).
It is important to use Cefizox for the full course of treatment. Failure to do so may decrease the effectiveness of Cefizox and may increase the risk that the bacteria will no longer be sensitive to Cefizox and will not be able to be treated by this or certain other antibiotics in the future.
LAB TESTS may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Cefizox during pregnancy. Cefizox is excreted in breast milk. Do not breast-feed while taking Cefizox.

--------------------------------------------------------------
Possible side effects of Cefizox:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Fever; mild diarrhea; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; pain, swelling, or redness at the injection site; seizures; severe diarrhea; stomach cramps/pain; vaginal irritation or discharge; yellowing eyes and skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

--------------------------------------------------------------
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include muscle spasms; seizures.

Proper storage of Cefizox:
Cefizox is usually handled and stored by a health care provider. If you are using Cefizox at home, store Cefizox as directed by your pharmacist or health care provider. Keep Cefizox, as well as needles and syringes, out of the reach of children and away from pets.

--------------------------------------------------------------
General information:
If you have any questions about Cefizox, please talk with your doctor, pharmacist, or other health care provider.
Cefizox is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Cefizox. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.