繁体中文
设为首页
加入收藏
当前位置:药品说明书与价格首页 >> 抗感染类 >> 药品目录 >> 抗生素类 >> 其它抗菌抗生素类 >> 咪康唑口服凝胶(Daktarin Gel)

咪康唑口服凝胶(Daktarin Gel)

2011-06-07 22:31:45  作者:新特药房  来源:中国新特药网天津分站  浏览次数:1530  文字大小:【】【】【
简介: Manufacturer Janssen-Cilag Distributor DKSH Contents Miconazole Indications Therapeutic & prophylactic treatment of candidosis of the oropharyngeal cavity & the GI tract. Dosage Oropharyn ...
Manufacturer Janssen-Cilag 
Distributor DKSH 
Contents Miconazole
Indications Therapeutic & prophylactic treatment of candidosis of the oropharyngeal cavity & the GI tract.
Dosage Oropharyngeal candidosis Adult & childn ≥2 yr ½ measuring spoon qid. Infant 6-24 mth ¼ measuring spoon qid. Do not swallow gel immediately, keep in the mouth as long as possible. GI tract candidosis Adult, childn, infant ≥6 mth 20 mg/kg body wt/day in 4 divided doses. Max: 250 mg qid.
Contraindications Liver dysfunction, infants <6 mth, concomitant ergot alkaloids, HMG-CoA reductase inhibitors (eg simvastatin, lovastatin), triazolam, oral midazolam & substrates known to prolong QT-interval (eg astemizole, bepridil, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole, terfenadine).
Special Precautions Ensure gel does not obstruct the throat esp in infants & young childn. Pregnancy, lactation.
Adverse Drug Reactions Nausea, regurgitation of food, vomiting.
View ADR Monitoring Form
Drug Interactions Warfarin, sulfonylureas, phenytoin, saquinavir, vinca alkaloids, busulfan, docetaxel, dihydropyridines, verapamil, cyclosporin, tacrolimus, sirolimus, alfentanil, alprazolam, brotizolam, buspirone, carbamazepine, cilostasol, disopyramide, ebastine, methylprednisolone, midazolam IV, reboxetine, rifabutin, sildenafil, trimetrexate.
View more drug interactions with Daktarin Oral Gel
Pregnancy Category (US FDA)      
     
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus. 
MIMS Class Mouth/Throat Preparations
ATC Classification A01AB09 - Miconazole ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. 
Daktarin Oral Gel gel  Daktarin Oral Gel 2 % x 10 g

How does it work?
Daktarin oral gel contains the active ingredient miconazole. Miconazole is an antifungal medicine used to treat infections with fungi and yeasts.

Miconazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the fungal cell membrane, causing holes to appear in it.

The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As miconazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi and treats the infection.

Miconazole also has some antibacterial action and kills certain bacteria that may also be present in the infection.

Daktarin oral gel is used to treat fungal infections of the mouth and throat, such as oral thrush. The gel should be held in the mouth for as long as possible before swallowing. For treating localised areas of infection in the mouth, a small amount of gel may be applied directly to the affected area with a clean finger. Daktarin oral gel can also be taken to treat fungal infections of the intestines.

What is it used for?
Prevention and treatment of fungal infections of the mouth, throat, stomach and intestines.
Daktarin oral gel can also be bought from pharmacies without a prescription, but only for treating and preventing fungal infections of the mouth and throat such as oral thrush.
Warning!
Daktarin oral gel should be taken after eating. When treating mouth and throat infections the gel should be held in the mouth for as long as possible before swallowing.
Daktarin oral gel is sticky. You should be careful to ensure that the gel doesn't obstruct the throat, as this may cause choking, particularly in children. The gel should not be put at the back of the throat, and the prescribed dose may be divided into smaller portions.
If you have false teeth (dentures) and are treating oral thrush you should brush the gel onto your dentures after you take them out at night to kill any fungus that may be on the dentures.
Treatment with this medicine should be continued for two days after the symptoms have cleared up to ensure the infection is fully treated and thus help prevent it coming back.
Not to be used in
Infants under four months of age, or those whose swallowing reflex is not yet fully developed.
Decreased liver function.
Hereditary blood disorders called porphyrias.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine is not recommended for use during pregnancy unless considered essential by your doctor. It should only be used if the expected benefit to the mother is greater than any possible risk to the foetus. Seek medical advice from your doctor.
It is not known if this medicine passes into breast milk. It should be used with caution in nursing mothers, and only if the benefits to the mother outweigh any risks to the nursing infant. Discuss this with your doctor.
Label warnings
Take at regular intervals. Complete the prescribed course unless otherwise directed.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Nausea.
Vomiting.
Diarrhoea.
Allergic reactions.
Inflammation of the liver (hepatitis).
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

This medicine should not be taken by people who are taking any of the following medicines:

astemizole
cisapride
ergot alkaloids, eg ergotamine, methysergide
midazolam taken by mouth
mizolastine
pimozide
quinidine
sertindole
statins for lowering cholesterol, eg simvastatin and lovastatin
terfenadine
triazolam.
This medicine increases the anti-blood-clotting effect of anticoagulant medicines such as warfarin, nicoumalone and phenindione, which may increase the risk of bleeding. If you are taking an anticoagulant your doctor may want to monitor your blood clotting time (prothrombin time or INR) during and after a course of this medicine, and may need to alter the dose of your anticoagulant as a result.

Miconazole may increase the blood levels of the following medicines. As this could increase the risk of side effects, your doctor may need to reduce the dose of these medicines if you are taking them in combination with miconazole:

benzodiazepines such as alprazolam
buspirone
busulfan
calcium channel blockers such as felodipine, nifedipine
carbamazepine
ciclosporin
cilostazol
phenytoin
protease inhibitors for HIV infection, eg saquinavir
reboxetine
rifabutin
sirolimus
sulphonylureas used for diabetes, eg glibenclamide, gliclazide and tolbutamide (the blood sugar lowering effect of these medicines may be enhanced, which may cause hypoglycaemia)
tacrolimus.


它是如何工作的?
Daktarin口服凝胶含有的活性成分咪康唑。达克宁是抗真菌药用于治疗真菌和酵母菌感染。

通过与咪康唑杀死其细胞膜干扰真菌和酵母菌。它的工作原理是阻止所谓的麦角固醇产生的物质,这是一个真菌细胞膜的重要组成部分的真菌。在麦角固醇生产中断破坏真菌细胞膜,导致孔出现在它。

真菌的细胞膜是他们的生存至关重要。他们不断进入细胞,阻止有害物质泄漏出来的单元格的内容。象洞咪康唑原因出现在细胞膜的重要成分真菌细胞可以泄漏出去。这杀死真菌和治疗感染。

达克宁也有一些特定的抗菌作用,杀死细菌,也可能在感染存在。

Daktarin口服凝胶,用于治疗真菌感染的口腔和喉咙,如鹅口疮。凝胶要为尽可能长时间吞咽之前在口中。在口腔治疗的感染局部地区,少量的凝胶,可直接用于受灾地区用干净的手指。 Daktarin口服凝胶,也可以采取治疗肠道真菌感染。

它是干什么用的?
预防和口腔,咽喉,胃和肠道真菌感染的治疗。
Daktarin口服凝胶,也可以从药店购买的非处方药,但仅用于治疗和预防如真菌感染,鹅口疮,口腔和喉咙。
警告!
Daktarin应采取口服凝胶后食用。在治疗口腔和咽喉感染的凝胶要为尽可能长时间吞咽之前在口中。
Daktarin口服凝胶粘。你应该小心,以确保不妨碍胶喉,因为这可能会导致窒息,特别是儿童。凝胶不应该摆在后面的喉咙,和规定的剂量可以划分为更小的部分。
如果你有(假牙)假牙,是治疗鹅口疮你应该把你的假牙刷凝胶后,您在夜晚出来杀真菌,任何可能对假牙。
用这种药治疗应持续两天后症状已消除,以确保充分的感染,从而有助于预防治疗回来过。
为了不被使用
四个月的婴儿年龄,或者那些吞咽反射尚未发育完全。
降低肝脏的功能。
遗传性血液疾病称为卟啉。
这种药不应该使用如果你是过敏它的一个或任何一种成分。请告知你的医生或药剂师,如果您以前经历过这样的过敏。

如果你觉得你已经经历了过敏性反应,停止使用此药,并告知你的医生或药剂师立即。

怀孕和哺乳
某些药物不应怀孕或哺乳期间使用。然而,其他药物可安全地用于提供在怀孕或哺乳母亲的益处大于风险的胎儿。始终告知你的医生,如果你正在怀孕或计划怀孕前使用任何药物。

此药在怀孕期间不建议,除非你的医生认为必要使用。它应仅用于造福于预期的妈妈比任何可能对胎儿的风险更大。请向您的医生。
目前还不清楚,如果这种药物进入乳汁通行证。应慎用于哺乳期妇女,只有在对母亲的益处超过任何风险,护理婴儿。与医生讨论这一点。
警告标签
采取定期。完成规定的课程,除非另有指示。
副作用
中药及其可能产生的副作用可能会影响个别人以不同的方式。以下是已知的一方,要与此药相关的一些影响。仅仅因为一个副作用就是这里所说的并不意味着所有的人使用这种药的经验,或任何副作用。

恶心。
呕吐。
腹泻。
过敏反应。
肝脏炎症(肝炎)。
上面列出的一方可能不包括所有效果的副作用报告的医药制造商。

如需使用此药有关的任何其他可能的风险的信息,请阅读药物所提供的资料或咨询你的医生或药剂师。

这种药怎么能影响其他药物?
重要的是要告诉您的医生或药剂师什么药,你已经采取,包括非处方药和草药买的,然后再开始与此药治疗。同样的,请与您的医生或药剂师,在采取任何新的药物,同时服用这一块,以确保组合是安全的。

这种药不应该被人们谁正在采取下列药物之一:

息斯敏
西沙必利
麦角生物碱,如麦角胺,麦角新碱
通过口服咪唑安定
咪唑斯汀
匹莫齐特
奎尼丁
sertindole
他汀类药物对降低胆固醇,如辛伐他汀和洛伐他汀
特非那丁
三唑仑。
这种药会增加抗凝血药物如华法令,nicoumalone和phenindione,这可能会增加出血的危险性抗凝血作用。如果你正在服用抗凝血药的医生可能要监控你的血液凝血时间期间和之后,这种药的课程(凝血酶原时间或INR),并可能需要改变你作为一个结果抗凝血剂的剂量。

达克宁可能会增加以下药物的血药浓度。因为这会增加副作用的风险,医生可能需要减少这些药物的剂量,如果你正与咪康唑组合它们:

阿普唑仑等苯二氮
丁螺环酮
马利兰
如非洛地平,钙通道阻滞剂硝苯地平
卡马西平
环孢素
西洛他唑
苯妥英
感染艾滋病毒蛋白酶抑制剂,如沙奎那韦
瑞波西汀
利福布丁
西罗莫司
用于治疗糖尿病磺脲类,如格列本脲,格列齐特和甲苯磺丁脲(降血糖的作用,这些药物可能会增强,这可能会导致低血糖)
他克莫司。 

责任编辑:admin


相关文章
 

最新文章

更多

· VICCILLIN-S FOR INJECT...
· VICCILLIN-S COMBINATIO...
· Clarith(克拉霉素小児用...
· Flucloxacillin Solutio...
· 琥乙红霉素干混悬剂|E.E...
· ANAEMETRO Intravenous ...
· 利福昔明片|XIFAXANTA(R...
· Orbactiv(oritavancin)注...
· Sivextro(tedizolid 磷酸酯)
· ACETYLSPIRAMYCIN(乙酰螺...

推荐文章

更多

· VICCILLIN-S FOR INJECT...
· VICCILLIN-S COMBINATIO...
· Clarith(克拉霉素小児用...
· Flucloxacillin Solutio...
· 琥乙红霉素干混悬剂|E.E...
· ANAEMETRO Intravenous ...
· 利福昔明片|XIFAXANTA(R...
· Orbactiv(oritavancin)注...
· Sivextro(tedizolid 磷酸酯)
· ACETYLSPIRAMYCIN(乙酰螺...

热点文章

更多