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英文药名: Ventavis (iloprost Nebule)
中文药名: 万他维(吸入用伊洛前列素)
生产品牌药厂家: Bayer Corporation
药品说明
商品名:万他维
通用名:吸入用伊洛前列素溶液
英文名:Ventavis
剂型:喷剂
主要成分:伊洛前列素
性状:本品为无色或微黄色的澄清液体，3毫升I型无色玻璃安瓿内含2毫升吸入用伊洛前列素溶液。
适应症:治疗中度原发性肺动脉高压。
用法用量:
成人：每次吸入应从2.5微克开始(吸入装置中口含器所提供的剂量)。可根据不同患者的需要和耐受性逐渐增加伊洛前列素剂量至5.0微克。
根据不同患者的需要和耐受性，每天应吸入伊洛前列素6-9次。
根据口含器与雾化器所需的药物剂量，每次吸入时间大约应为5-10分钟。
肾功能或肝功能不全患者：肝功能异常以及肾功能衰竭需要血液透析的患者，伊洛前列素的清除率是降低的，应考虑减少用药剂量.
儿童以及青少年（18岁以下）：目前还没有在儿童或青少年中应用的经验。除非有资料支持，否则本药不能应用于18岁以下的患者.
雾化器的使用：如果某种雾化器能达到下列标准，则认为它适用于本药溶液的雾化：
液滴的中位空气动力学直径（MMAD）或中位直径（MMD）为3-4m；
口含器输出剂量为：每次吸入伊洛前列素2.5或5ug；
一个剂量为2.5或5ug伊洛前列素的雾化时间：大约为4-10分钟（为了避免全身性副作用，4分钟内输出的伊洛前列素不得超过5ug）。
禁忌:以下患者禁用：
-对伊洛前列素或任何赋形剂过敏。
-出血危险性增加的疾病（如活动性消化性溃疡，外伤，颅内出血或者其他出血），由于本药对血小板的作用可能会使出血的危险性增加。
-患有心脏病的患者，如：严重心律失常、严重冠状动脉性心脏病、不稳定性心绞痛、发病6个月内的心肌梗塞、未予控制和治疗的或未在严密检测下的非代偿性心力衰竭、先天性或获得性心脏瓣膜疾病伴非肺动脉高压所致的有临床意义的心肌功能异常。
-明显的肺水肿伴呼吸困难。
-近3个月发生过脑血管事件（如短暂性脑缺血发作、中风）或其他脑供血障碍。
-妊娠，哺乳妇女。
不良反应:
除了由于吸入用药的局部不良反应如咳嗽加重外，吸入伊洛前列素的不良反应主要与前列环素药理学特性有关。临床试验中最常见的不良反应包括血管扩张，头疼以及咳嗽加重。
【原产地英文商品名】VENTAVIS SOLUTION FOR INHALATION 20MCG/2MLS/AMPUL 30AMPULS/BOX
【原产地英文药品名】ILOPROST
【中文参考商品译名】
注：以下产品不同规格和不同价格，购买时请以电话咨询为准！
·万他维溶液吸入剂 10微克/毫升/安醅 100安醅/盒
·万他维溶液吸入剂 20微克/2毫升/安醅 30安醅/盒
【中文参考药品译名】伊洛前列素
【生产厂家中文参考译名】ACTELION PHARMS LTD
【生产厂家英文名】ACTELION PHARMS LTD
另名：菲塔敏思 霧化液 2 毫升
英文產品名: Ventavis Nebulser Solution
學名: Iloprost
菲塔敏思適用於:
原發性肺動脈高壓。
What is Ventavis?
Ventavis is a prescription medicine used to treat adults with certain kinds of severe pulmonary arterial hypertension (PAH), a condition in which blood pressure is too high in the blood vessels between the heart and the lungs. Ventavis may improve your ability to exercise and your symptoms for a short time by lowering your blood pressure and opening up the blood vessels in your lungs.
•In the key clinical study, Ventavis showed clinical improvement as defined by 3 specific measurements: ability to exercise as measured by the 6-minute walk test, symptoms (NYHA Functional Class), and decrease in the worsening of PAH symptoms.
•Ventavis is a medication you breathe in through a special device called the I-neb Adaptive Aerosol Delivery (AAD) System.
The study showing Ventavis is effective included mainly patients with NYHA Functional Class III-IV PAH. In these patients, PAH was caused by unidentified or hereditary factors (65%) or connective tissue diseases (23%).
Ventavis has not been studied in children younger than 18 years old.
How is Ventavis taken?
Ventavis is inhaled through a special device called the I-neb AAD System, which is compact, portable, and lightweight—so you can take your medication almost anywhere at any time. Inhaling Ventavis helps it get right to the lungs—the site of disease.1
How can Ventavis help?
The benefits of Ventavis therapy† ‡:
•Ventavis is the only inhaled PAH* therapy that can be given alone to help patients improve their PAH* symptoms and walk farther. It can also be safely used with many other drugs.
•Patients felt better doing ordinary physical activities and improved their NYHA Functional Class.1
•Patients were able to walk farther in a timed test.1
•Ventavis decreased the worsening of PAH* symptoms.1
*What is Ventavis?
Ventavis is a prescription medicine used to treat adults with certain kinds of severe pulmonary arterial hypertension (PAH), a condition in which blood pressure is too high in the blood vessels between the heart and the lungs. Ventavis may improve your ability to exercise and your symptoms for a short time by lowering your blood pressure and opening up the blood vessels in your lungs.
•In the key clinical study, Ventavis showed clinical improvement as defined by 3 specific measurements: ability to exercise as measured by the 6-minute walk test, symptoms (NYHA Functional Class), and decrease in the worsening of PAH symptoms.
•Ventavis is a medication you breathe in through a special device called the I-neb Adaptive Aerosol Delivery (AAD) System.
The study showing Ventavis is effective included mainly patients with NYHA Functional Class III-IV PAH. In these patients, PAH was caused by unidentified or hereditary factors (65%) or connective tissue diseases (23%).
Ventavis has not been studied in children younger than 18 years old.
What is the most important information I should know about Ventavis?
Ventavis may not be right for you. Before taking Ventavis, tell your doctor about all of your medical conditions, including if you have liver or kidney problems; are pregnant, or plan to become pregnant; or are breast-feeding. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take medicines used to treat high blood pressure or heart problems or medicines that lessen blood clotting (warfarin, Coumadin, Jantoven). Ventavis and other medicines may affect each other, causing side effects.
What are the possible side effects of Ventavis?
•Ventavis may cause side effects, including feeling dizzy, lightheaded, and faint. If you have any of these side effects, you should stand up slowly when you get out of chairs or bed. Tell your doctor if your fainting gets worse during treatment with Ventavis. Your doctor may need to change your dose or treatment.
•Do not drive a car or operate any tools or machines if dizziness or fainting from low blood pressure is a problem for you.
•You may have trouble breathing after taking Ventavis, because it may cause the muscles around your airway to tighten (bronchospasm). Get emergency help right away if you have trouble breathing.
•The most common side effects of Ventavis include red face (flushing), increased cough, low blood pressure, headaches, nausea, spasm of your jaw muscles that makes it hard to open your mouth, and fainting.
Talk to your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Ventavis. For more information, ask your doctor or pharmacist. | 
