英文药名: Symbicort (Budesonide/Formoterol Turbuhaler)
中文药名: 信必可（布地奈德福莫特罗都保）
生产厂家: AstraZeneca
药品名称
商品名: 信必可都保 / SYMBICORT TURBUHALER
通用名: 布地奈德福莫特罗粉吸入剂
生产厂家
AstraZeneca
适应症
本品适用于需要联合应用吸入皮质激素和长效b2?受体激动剂的哮喘病人的常规治疗：
- 吸入皮质激素和“按需”使用短效b2?受体激动剂不能很好地控制症状的患者。
- 应用吸入皮质激素和长效b2?受体激动剂，症状已得到完全控制的患者。
用法用量
本品不用于哮喘的初始治疗。本品应个体化用药，并根据病情的严重程度调节剂量，这在开始使用复方制剂时需要注意。如果某个患者所需剂量超出推荐剂量，则应增开适当剂量的β-受体激动剂和/或皮质激素的处方。
推荐剂量：
成年人（18岁和18岁以上）：1-2吸/次，一日2次，有些病人可能需要使用量达到4吸/次，一日2次。
青少年（12-17岁）：1-2吸/次，一日2次。
儿童（6岁和6岁以上）：2吸/次，一日2次。
任何疑问，请遵医嘱！
不良反应
因为本品含有布地奈德和福莫特罗，这两种药物的不良反应在使用本品时也可出现。两药合并使用后，不良反应的发生率未增加。最常见的不良反应是β2?受体激动剂治疗时所出现的可预期的药理学不良反应，如震颤和心悸。这些反应通常可在治疗的几天内减弱或消失。
常见(>1/100,<＝1/10):头痛、心悸、震颤、口咽部念珠菌感染、咽部轻度刺激、咳嗽和声嘶。
不常见(>1/1000,<1/100)：心动过速、肌肉痉挛、焦虑、躁动、紧张、恶心、眩晕、睡眠紊乱、瘀斑。
禁忌
对布地奈德、福莫特罗或吸入乳糖有过敏反应的病人禁用。
规格 (1)100/6微克 (2)200/6微克
Why is it prescribed?
Symbicort® turbuhaler contains budesonide and formoterol fumarate.
For Symbicort® turbuhaler there are two treatment approaches:
- A. Symbicort Mainetenance Therapy: Symbicort® can be used for maintenance treatment with a separate rapid-acting bronchodilator medication for rescue.
- B. Symbicort Maintenance and Reliever Therapy: Symbicort® can also be used as both a maintenance treatment and a rapid-acting rescue medication as needed in response to symptoms.
Symbicort® is indicated for regular treatment of asthma in patients 12 years of age and older with reversible obstructive airways disease, where the use of two medications is appropriate. This includes people already using a long acting bronchodilator and a separate inhaled corticosteroid medication and those using the recommended doses of an inhaled anti-inflammatory drug but still experiencing regular or frequent breakthrough symptoms (e.g. coughing and wheezing) which require the use of rescue bronchodilators.
Symbicort® turbuhaler is indicated for the maintenance treatment of moderate to severe COPD including chronic bronchitis and emphysema, in patients with persistent symptoms and a history of exacerbations, where the use of a combination product is considered appropriate.
Symbicort® turbuhaler is not indicated for the relief of acute bronchospasm in COPD patients.
Side Effects
Symbicort® turbuhaler contains budesonide and formoterol fumarate.
Along with its needed effects, Symbicort® turbuhaler may cause some unwanted or undesirable effects.
Generally, Symbicort® turbuhaler is well tolerated and many people will not experience unwanted effects.
Very occasionally, some people may feel a little shaky or have a headache or notice that their heart is beating faster than usual. Other side effects include sleeping difficulties, restlessness or nervouseness, dizziness, sickness and muscle cramps. Tell your doctor but do not stop using the medicine unless told to do so.
Some people may have a mild irritation in their throat or cough after taking the medicine or that their voice becomes a little hoarse. In some people, a mild fungal infection known as thrush may occur. Rare side effects include skin rash and bruising, itching, facial swelling, increase in chest tightness, chest pain, depression or behavioural disturbances and high blood sugar levels. If you experience any unwanted effects contact your doctor or pharmacist.
It is important not to exceed the number of inhalations as prescribed by your doctor of Symbicort® turbuhaler. Doing so increases the risk of potentially serious unwanted effects.
If your rescue medication (Symbicort® or short-acting bronchodilator) is not working as well as it usually does and/or you need more frequent doses to control breakthrough symptoms, your asthma may be worsening. Your condition should be reassessed by your doctor immediately.
Be sure to tell your doctor and pharmacist about any prescription and over-the-counter medications you are taking in order to avoid any potential drug interactions. Some medications known to interact with Symbicort® turbuhaler include beta-blockers used for certain heart conditions (e.g., propranolol, high blood pressure (e.g., atenolol), eye conditions (e.g., timolol)and medications to treat fungal infections (e.g., ketoconazole)
Use of Symbicort® is not recommended in the following situations:
- allergy to formoterol
- allergy to budesonide or any component of the preparation
- allergy to lactose
- cardiac arrhythmia (irregular heartbeat), especially increased heart rate arrhythmias
- people with tuberculosis
- untreated fungal, bacterial and viral infections
Caution is recommended in the following situations:
- people previously treated for prolonged periods with oral corticosteroids (e.g. prednisone)
- hyperthyroidism
- diabetes
- heart disease
- high blood pressure Use in pregnancy: If you suspect that you might be pregnant or if you plan to become pregnant, consult your doctor.
Use while breastfeeding: It is not known whether budesonide is passed into breast milk, but it is suspected. Formoterol is probably passed into breast milk. Consult your doctor or pharmacist before you begin breastfeeding.
As with all long-acting beta-2 agonists and beta-2 agonist/corticosteroid combinations, Symbicort® carries a warning that long-acting beta-2 agonists have been associated with asthma death. These warnings are based on a U.S. study using salmeterol.
Use in children: Symbicort® turbuhaler is not currently recommended in children younger than 12 years of age due to limited clinical data in this age group.
Patient Information
Symbicort® turbuhaler is intended for continual use on a regular basis to prevent symptoms. It can also be used between regular doses as a rescue medication if needed or a short-acting bronchodilator e.g., salbutamol can be used between regular doses as a rescue medication.
After inhaling a dose, be sure to rinse your mouth with water and spit it out. This may help prevent developing the fungal infection of the mouth and throat called thrush.
If you accidently take more than the recommended number of inhalations, you may notice that your heart is beating faster than usual, that you have a headache and that you feel shaky. In this case, immediately contact your doctor.
If you miss a scheduled dose of Symbicort® turbuhaler, take it as soon as you remember and then go back to your regular schedule. Never take a double dose of Symbicort® turbuhaler to make up for missed doses. If you are still unsure, check with your pharmacist. Your doctor or pharmacist should have instructed you on the proper use and care of your Symbicort® turbuhaler. It is advisable to have your technique reassessed by the pharmacist for the first 2 or 3 refills of your prescription.
The Symbicort® turbuhaler should be kept clean and dry at all times. Never breathe out into the device or use any fluids to clean it. Clean the outside of the mouthpiece once a week with a dry tissue. Each Symbicort® turbuhaler has its own built in drying agent located in the brown turning grip. If you shake the device, you can hear it. The dose indicator tells you how many doses are left in the inhaler. The dose indicator tells you how many doses are left in the inhaler. Every 20th dose is marked with a number and every 10th dose is marked with a dash. The inhaler is empty when the "0" on the red background has reached the middle of the window. If you shake the device when it is empty, you will still be able to hear the sound of the drying agent.
The device is not refillable and should be discarded when empty.
Children using the device should be supervised by an adult who knows how to use it properly.
Always replace the cover after use and keep away from moisture.
Rinsing the mouth with water and spitting out after each use will remove any remaining medication to help prevent local yeast (thrush) infections. Cleansing dentures has the same effect. Notify your doctor if a sore throat or mouth occurs or if you suspect a localized yeast infection.Directions for Use
The dosage of Symbicort® turbuhaler is individual. Follow your doctor's instructions carefully.
If using Symbicort® for prevention only, the recommended dose in adults and children 12 years of age and older is 1 to 2 inhalations of Symbicort® turbuhaler 100mcg or 200 mcg once or twice daily (maximum daily dose 4 inhalations).
If using Symbicort® for prevention and rescue, the recommended dose in adults and children 12 years of age and older is 1 to 2 inhalations of Symbicort® turbuhaler 100 mcg or 200 mcg twice daily or 2 inhalations once daily. For rescue, 1 additional inhalation should be taken as needed for relief of symptoms. If symptoms continue after a few minutes, another 1 inhalation should be taken. No more than 6 inhalations should be used at one time. The maximum recommended total daily dose is 8 inhalations.
COPD: Oral inhalation: Two inhalations twice daily (maximum: 4 inhalations/day)Lung Diseases Treated with this Drug
budesonide
- allergic rhinitis
- asthma
- hay fever
- nasal polyps
- perennial rhinitis
- rhinitis
- runny nose
- seasonal rhinitis
- asthma
- bronchospasm associated with COPD
- chronic bronchitis (COPD)
- COPD
- emphysema (COPD)
Need More Information?
For more information contact your physician, pharmacist, other health care professional or for general questions call your local lung association.