【中文品名】舒马曲坦
【药效类别】抗偏头痛药
【通用药名】SUMATRIPTAN
【别 名】舒马普坦
【化学名称】 1H-Indole-5-methanesulfonamide, 3-[2-(Dimethylamino)ethyl]-2,3-dihydro-N-methyl-
【CA登记号】[103628-46-2]
【结 构 式】
【分 子 式】C14H21N3O2S
【分 子 量】
【收录药典】JP14
【开发单位】GLAXOSMITHKLINE
【适应症】用于成人有先或无先兆偏头痛的急性发作。
【用法和用量】
单次口服的推荐剂量为50mg（2片），用水送服，若服用1次后无效，不必再加服。如果在首次服药后有效，但症状仍持续发作者可于2小时后再加服1次。若服用后症状消失，但之后又复发者，应待前次给药24小时后方可再次用药。单次口服的最大推荐剂量为100mg（4片）。24小时内的总剂量不得超过200mg（8片）。
【不良反应】
1.对照性临床研究中心发生率达2%以上的不良反应有：
（1）非典型感觉：感觉异常（各种类型）；发热或发冷
（2）疼痛和压迫感
（3）神经系统：眩晕
（4）其它：倦怠、疲劳。其它发生率超过1%或者至少与安慰剂发生率相当的不良反应包括恶心和/或呕吐偏头痛，头痛，唾液分泌减少，头昏，嗜睡。舒马普坦片耐受性通常比较低，在各种剂量下，绝大多数不良反应均较轻微而持续时间短，不至于造成长时间的影响。
【注意事项】
1.本品不得用于存在缺血性心脏病、缺血性脑血管病和缺血性外周血管病等疾病病史、症状和体征的患者。另外，其它症状明显的心血管疾病亦不应接受本品治疗。
2.正在使用或两周内使用过单胺氧化酶的患者禁用本品。
3.舒马普坦不得用于偏瘫所致偏头痛和椎基底动脉病变所致的头痛。 4.24小时内用过任何麦角胺类药物或包含麦角胺类的药物（如双氢麦角胺或二氢麦角胺新碱）的患者禁用舒马普坦。本品亦不得与其它5-HT激动剂并用。
5.本品禁用于严重肝功能损害的患者。
6.对舒马普坦过敏者禁用。
7.禁用于未经控制的高血压患者。
【贮藏】密封，阴凉处保存。
【有效期】 18个月
Sumatriptan 100mg Tablets - Generic Imitrex
Sumatriptan 100mg Tablets - Generic Imitrex
Imitrex are used for:
The treatment of migraine headaches with or without aura (eg, flashing lights, wavy lines, dark spots). It may also be used for other conditions as determined by your doctor.
Imitrex are a serotonin 5-HT 1 receptor agonist ("triptan"). It works by narrowing blood vessels in the brain, which helps to relieve migraines.
Do NOT use Imitrex if:
you are allergic to any ingredient in Imitrex
you have a history of ischemic heart disease (eg, angina, heart attack), coronary artery disease (CAD), other moderate to severe heart problems, brain blood vessel disease (eg, stroke, transient ischemic attack), or other blood vessel disease (eg, Raynaud syndrome, ischemic bowel disease)
you have uncontrolled high blood pressure or severe liver problems
you have certain types of migraines (eg, hemiplegic, basilar)
you are taking or have taken a monamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days
you have used certain other migraine medicines within the past 24 hours (eg, an ergot derivative [eg, dihydroergotamine, methysergide], another serotonin 5-HT 1 receptor agonist [eg, eletriptan, rizatriptan])
you are taking sibutramine
Before using Imitrex:
Some medical conditions may interact with Imitrex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have history of liver or kidney problems, seizures (eg epilepsy), heart problems, or other types of headaches (eg, cluster headaches)
if you have shortness of breath, chest pain, or a history of high blood pressure, heart attack, stroke, high cholesterol, diabetes, or smoking
if you are a woman who is past menopause
if you are a man who is more than 40 years old
if you are very overweight
if a family member has had heart disease
Some MEDICINES MAY INTERACT with Imitrex. Tell your health care provider if you are taking any other medicines, especially any of the following:
Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), orsibutramine because the risk of a serious side effect called serotonin syndrome may be increased. Symptoms of serotonin syndrome may include mental or mood changes, hallucinations, fast heartbeat, fever, loss of coordination, muscle spasms, increased sweating, nausea, vomiting, or diarrhea
MAOIs (eg, phenelzine) because they may increase the risk of Imitrex's side effects
Ergot derivatives (eg, dihydroergotamine, methysergide) or other serotonin 5-HT 1 receptor agonists (eg, eletriptan, rizatriptan) because the risk of their side effects may be increased by Imitrex
How to use Imitrex:
Use Imitrex as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with Imitrex. Talk to your pharmacist if you have questions about this information.
Take Imitrex by mouth with or without food.
Swallow Imitrex whole. Do not break, crush, or chew before swallowing.
It is best to take a dose of Imitrex as soon as you notice symptoms of a migraine attack.
If your migraine symptoms go away and then come back, or if you have a partial response to the first dose, you may take a second dose as directed by your doctor. Wait at least 2 hours between doses.
If your symptoms do not improve after the first dose, do not take a second dose for the same attack. Contact your doctor.
Do not take more than the amount prescribed by your doctor in a 24-hour period or treat more than 4 headaches within 30 days without checking with your doctor.
If you miss a dose of Imitrex and you still have a headache, follow your doctor's dosing instructions. Contact your doctor immediately if you are unsure of what to do if you miss a dose. Do not take Imitrex more often than prescribed. Do not take 2 doses at once.
Important safety information:
Imitrex may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Imitrex with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Overuse of Imitrex can cause your headache to become worse. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.
Rarely, serious heart problems (eg, heart attack, irregular heartbeat) have been reported within a few hours of using Imitrex. Contact your doctor at once if fast or irregular heartbeat; chest, jaw, or neck pain or numbness; numbness of an arm or leg; severe stomach pain, dizziness, or vomiting; fainting; or vision changes occur. Discuss any questions or concerns with your doctor.
Serotonin syndrome is a possibly fatal syndrome that can be caused by Imitrex. Your risk may be greater if you take Imitrex with certain other medicines (eg, SSRIs, SNRIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
Imitrex should not be used to prevent or reduce the number of migraine headaches you have. If you have a headache that is different than your usual migraine headaches, check with your doctor before using Imitrex.
Lab tests, including heart function tests, may be performed while you use Imitrex. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Imitrex should not be used in the ELDERLY; the risk of serious side effects (eg, heart problems, high blood pressure) may be increased.
Imitrex should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
PREGNANCY and BREAST-FEEDING: It is not known if Imitrex can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Imitrex while you are pregnant. Imitrex are found in breast milk. If you are or will be breast-feeding while you use Imitrex, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Imitrex:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Burning; dizziness; drowsiness; feeling of heaviness or pressure; muscle aches; numbness or tingling of the skin; sick feeling; tingling; tiredness; warm/hot sensation.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; chest pain; confusion; fainting; fast or irregular heartbeat; fever; hallucination; hearing problems; numbness or tingling of an arm or leg; one-sided weakness; pain, tightness, or pressure in the jaw, neck, or chest; seizures; severe headache, dizziness, or vomiting; severe or prolonged flushing; severe stomach pain; shortness of breath; speech changes; very cold or blue fingers or toes; vision changes or loss of vision; wheezing. |
