英文药名: Edecrin(Ethacrynic Acid Tablets)

中文药名: 依他尼酸片

药品简介

【别   名】 依他尼酸, 利尿酸, 利尿酸钠
【外 文名】Acid Ethacrynic, EDECRIN, Crinuryl, Ecrinex, Edectrin, Ederil
【适 应症】 临床用于充血性心力衰竭、急性肺水肿、肾性水肿、肝硬变及腹水、肝癌腹水、血吸虫病腹水、脑水肿及其它水肿。
【用法用量】
1.口服：每次25ｍｇ，每日１～３次，如效果不显，可略增加，但１日量不宜超过100ｍｇ，３～５日为１疗程。
2.静注（用其钠盐）：每次２５～５０ｍｇ，偶需注射第２次时，应更换部位，以免发生血栓性静脉炎。临用前，以５％葡萄糖注射液或等渗盐水50ｍｌ稀释后缓慢滴注或静注，所配溶液在２４小时内用毕。３～５日为１疗程。
小儿剂量:0.5-1mg/(kg.次.d).
【注意事项】 与呋喃苯胺酸相似，但更易引起耳毒性；禁忌与慎用，同呋喃苯胺酸。
【规格】 片剂：每片25ｍｇ。 注射用利尿酸钠：每支含利尿酸钠25ｍｇ、甘露醇31.25ｍｇ。

 
Brand names: Edecrin®

Ethacrynic Acid tablets
What are ethacrynic acid tablets?

ETHACRYNIC ACID (Edecrin®) is a loop diuretic (water or fluid pill). Loop diuretics increase the amount of urine passed, which causes the body to lose water and salt. Ethacrynic acid is given as a diuretic in conditions that make the body retain water and produce swelling (edema), like heart failure, liver or kidney problems. It is not a cure. Generic ethacrynic acid tablets are not yet available.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• diabetes
• diarrhea
• gout
• hearing problems
• heart disease, or previous heart attack
• kidney disease, small amounts of urine, or difficulty passing urine
• liver disease
• low blood levels of calcium, potassium, chloride, sodium or magnesium
• pancreatitis
• systemic lupus erythematosus (SLE)
• an unusual or allergic reaction to ethacrynic acid, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I take this medicine?
Take ethacrynic acid tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. If ethacrynic acid upsets your stomach, take it with food or milk. Take your doses at regular intervals. Do not take your medicine more often than directed. Remember that you will need to pass urine frequently after taking ethacrynic acid. Do not take your doses at a time of day that will cause you problems. Do not take at bedtime.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What drug(s) may interact with ethacrynic acid?
• alcohol
• antiinflammatory drugs (NSAIDs, such as ibuprofen)
• certain antibiotics given by injection
• dofetilide
• heart medicines such as digoxin or digitoxin
• hormones such as cortisone, fludrocortisone, or hydrocortisone
• medicines for high blood pressure
• lithium
• monoamine oxidase inhibitors (Azilect®, Eldepryl®, Emsam®, Marplan®, Nardil®, Parnate®, Zelapar™)
• warfarin
• water pills
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking ethacrynic acid?
Visit your prescriber or health care professional for regular checks on your progress. Check your blood pressure regularly. Ask your prescriber or health care professional what your blood pressure should be, and when you should contact him or her. You must not get dehydrated, ask your prescriber or health care professional how much fluid you need to drink a day. Do not stop taking ethacrynic acid except on your prescriber's advice.
Watch your diet while you are taking ethacrynic acid. Ask your prescriber or health care professional about both potassium and sodium intake. Ethacrynic acid can make your body lose potassium and you may need an extra supply. Some foods have a high potassium content such as bananas, coconuts, dates, figs, prunes, apricots, peaches, grapefruit juice, tomato juice, and orange juice.
You may get dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how ethacrynic acid affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can make you lightheaded, dizzy and increase confusion. Avoid or limit intake of alcoholic drinks.
If you are going to have surgery, tell your prescriber or health care professional that you are taking ethacrynic acid.
What side effects may I notice from taking ethacrynic acid?
Side effects that you should report to your prescriber or health care professional as soon as possible:
• blood in the urine
• blurred vision
• dry mouth
• fever or chills
• hearing loss, ringing in the ears
• increased thirst
• irregular heartbeat
• muscle cramps, pain or weakness
• nausea, vomiting
• skin rash
• stomach pain
• unusual bleeding or bruising
• unusual tiredness or weakness
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• confusion
• diarrhea
• difficulty swallowing
• dizziness or lightheadedness
• headache
• loss of appetite
Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.