部分中文Geodon处方资料（仅供参考）
                     
甲磺酸齐拉西酮胶囊

学科分类：神经系统用药
通用名称：齐拉西酮甲磺酸盐
英文名称：ZIPRASIDONE　MESYLATE
化学名称为：5-[2-[4-（1，2-苯并异噻唑-3-基）-1-哌嗪基]-乙基]-6-氯-1，3-二氢-吲哚-2-酮甲磺酸盐
剂型剂量：注射剂
有效成分：齐拉西酮甲磺酸盐
药理作用：对于5羟色胺5-HT2受体和多巴胺D2受体都有拮抗作用
新药评价：是一种新的非典型的抗精神病药物，对精神分裂症或分裂情感性精神障碍者具有很好的抗精神病作用，并有较好的抗焦虑作用。该药的不良反应少，很少会引起锥外反应，几乎没有高催乳素血症，见效迅速。
适应症：本品适用于治疗精神分裂症患者急性激越症状。
用法用量：
肌肉注射：推荐剂量为每日10－20mg，最大剂量为每日40mg；如果每次注射10mg（一支），可每隔2小时注射一次；如果每次注射20mg（二支），可每隔4小时注射一次。尚未研究连续肌肉注射3天以上的疗效和安全性，如需长期治疗，应尽快改用口服盐酸齐拉西酮片。
由于没有评价精神病患者口服齐拉西酮后再肌注齐拉西酮的安全性，不推荐患者既口服又肌注齐拉西酮。
老年患者、肝功能或者肾功能损伤患者肌肉注射齐拉西酮的安全性尚未进行系统评价。肾功能损伤患者宜慎用。但不需根据性别和种族调整剂量。
不良反应：国外上市前临床试验报道，肌注齐拉西酮急性治疗期间，不良反应类型和发生率≥1%见下表。肌注齐拉西酮最常见的不良反应（发生率≥5%）为头痛（13%），恶心（12%）和嗜眠（20%）。

Geodon
Generic Name: ziprasidone (zi PRAY si done)
Brand Names: Geodon
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What is Geodon?
Geodon (ziprasidone) is an antipsychotic medication. It works by changing the effects of chemicals in the brain.
Geodon is used to treat schizophrenia and the manic symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old.
Geodon may also be used for other purposes not listed in this medication guide.
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Important information about Geodon
Geodon is not for use in psychotic conditions related to dementia. Geodon may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.
Do not use Geodon if you have a personal or family history of "Long QT syndrome," if you have recently had a heart attack, or if you have uncontrolled heart failure.
Stop taking Geodon and call your doctor right away if you feel dizzy or light-headed, have a fast or pounding heartbeat, or if you faint. This could be signs of a serious heart rhythm problem.
There are many other medicines that can cause serious or life-threatening medical problems if you take them together with Geodon.
Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins,
minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
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Before taking Geodon
Geodon is not for use in psychotic conditions related to dementia. Geodon may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Do not use this medication if you are allergic to ziprasidone, or if you have:a personal or family history of "Long QT syndrome";
history of recent heart attack; oruncontrolled or untreated heart failure.
Geodon should never be taken together with any of the following drugs, or a life-threatening heart rhythm disorder could occur:
arsenic trioxide (Trisenox);
dolasetron (Anzemet);
droperidol (Inapsine);
halofantrine (Halfan);
mefloquine (Lariam);
levomethadyl acetate (no longer available in the U.S.);
tacrolimus (Prograf);
antibiotics such as gatifloxacin (Tequin), pentamidine
(NebuPent, Pentam), moxifloxacin (Avelox), sparfloxacin (Zagam), telithromycin (Ketek);
heart rhythm medicine such as dofetilide (Tikosyn), disopyramide (Norpace), quinidine (Cardioquin, Quinaglute), or sotalol (Betapace); ormedicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take Geodon:
a heart rhythm disorder;
a history of heart attack or stroke;
a history of bone marrow or blood cell disorder;
low blood levels of potassium or magnesium;
diabetes (Geodon may raise your blood sugar);
seizures or epilepsy;
a history of suicidal thoughts;
Parkinson's disease, Alzheimer's;
trouble swallowing;
liver disease; or
kidney disease.
Geodon may cause you to have high blood sugar (hyperglycemia).
Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking Geodon.
The orally disintegrating tablet may contain phenylalanine.
Talk to your doctor before using this form of Geodon if you have phenylketonuria (PKU).
FDA pregnancy category C. It is not known whether Geodon is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether ziprasidone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from Geodon.
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How should I take Geodon?
Take Geodon exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
To be sure Geodon is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.
Take this medicine with food.
It is important to take Geodon regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
It may take several weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed.
Talk with your doctor if your symptoms do not improve. Store Geodon at room temperature away from moisture, light, and heat.
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What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
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What happens if I overdose?
Seek emergency medical treatment if you think you have used too much of this medicine. Overdose symptoms may include drowsiness, problems with speech, dizziness, feeling light-headed, fainting, fast or pounding heartbeat, or restless muscle movements in your eyes, tongue, jaw, or neck.
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What should I avoid while taking Geodon?
While you are taking Geodon, you may be more sensitive to temperature extremes such as very hot or cold conditions.
Avoid getting too cold, or becoming overheated or dehydrated.
Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking this medicine.
Geodon can cause side effects that may impair your thinking or reactions.
Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of Geodon.
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Geodon side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Geodon and call your doctor at once if you have any of these serious side effects:
dizziness, feeling light-headed, fainting, fast or pounding heartbeat;
stiff muscles, confusion, sweating, fast or uneven heartbeats;
fever, chills, body aches, flu symptoms;
white patches or sores inside your mouth or on your lips;
tremor (uncontrolled shaking), restless muscle movements in your eyes, tongue, jaw, or neck;
agitation, hostility, confusion;
increased thirst or urination, weakness, extreme hunger; orpenis erection that is painful or lasts 4 hours or longer.
Less serious Geodon side effects may include:
mild skin rash;
anxiety, headache, depressed mood;
dizziness, drowsiness;
muscle pain or twitching;
nausea, vomiting, loss of appetite;
runny or stuffy nose, cough, sore throat; or
weight gain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
You may report side effects to FDA at 1-800-FDA-1088.
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What other drugs will affect Geodon?
Before taking Geodon, tell your doctor if you regularly use any other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Geodon.
Tell your doctor about all other medications you are using, especially:
a diuretic (water pill), blood pressure medicine, or heart rhythm medicine;
carbamazepine (Carbatrol, Tegretol);
cisapride (Propulsid);
haloperidol (Haldol);
narcotic pain medication;
medicines used to treat Parkinson's Disease such as levodopa (Dopar, Larodopa, Sinemet, Atamet, others); orantibiotics such as azithromyci(Zithromax),clarithromycin
(Biaxin), erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab), ketoconazole (Nizoral), or telithromycin (Ketek).
This list is not complete and there may be other drugs that can interact with Geodon. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
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Where can I get more information?
Your pharmacist can provide more information about Geodon.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indicationprescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate,
up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United
States
and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a
warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.
Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings,
drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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原产地英文商品名:
GEODON 80mg/cap 60caps/box
原产地英文药品名:
ZIPRASIDONE HCL
中文参考商品译名:
GEODON 80毫克/胶囊 60胶囊/盒
中文参考药品译名:
盐酸齐拉西酮
中文参考化合物名称:
5-[2-[4-(1,2-苯并异噻唑-3-基)-1-哌嗪基]乙基]-6-氯-1,3-二氢-2(1H)-吲哚-2-酮盐酸盐半水合物
生产厂家中文参考译名:
辉瑞
生产厂家英文名:
PFIZER
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原产地英文商品名:
GEODON 60mg/cap 60caps/box
原产地英文药品名:
ZIPRASIDONE HCL
中文参考商品译名:
GEODON 60毫克/胶囊 60胶囊/盒
中文参考药品译名:
盐酸齐拉西酮
中文参考化合物名称:
5-[2-[4-(1,2-苯并异噻唑-3-基)-1-哌嗪基]乙基]-6-氯-1,3-二氢-2(1H)-吲哚-2-酮盐酸盐半水合物
生产厂家中文参考译名:
辉瑞
生产厂家英文名:
PFIZER
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原产地英文商品名:
GEODON 20mg/cap 60caps/box
原产地英文药品名:
ZIPRASIDONE HCL
中文参考商品译名:
GEODON 20毫克/胶囊 60胶囊/盒
中文参考药品译名:
盐酸齐拉西酮
中文参考化合物名称:
5-[2-[4-(1,2-苯并异噻唑-3-基)-1-哌嗪基]乙基]-6-氯-1,3-二氢-2(1H)-吲哚-2-酮盐酸盐半水合物
生产厂家中文参考译名:
辉瑞
生产厂家英文名:
PFIZER
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原产地英文商品名:
GEODON 40mg/cap 60caps/box
原产地英文药品名:
ZIPRASIDONE HCL
中文参考商品译名:
GEODON 40毫克/胶囊 60胶囊/盒
中文参考药品译名:
盐酸齐拉西酮
中文参考化合物名称:
5-[2-[4-(1,2-苯并异噻唑-3-基)-1-哌嗪基]乙基]-6-氯-1,3-二氢-2(1H)-吲哚-2-酮盐酸盐半水合物
生产厂家中文参考译名:
辉瑞
生产厂家英文名:
PFIZER