英文药名: Teosyal(hyaluronic acid)

中文药名: 透明质酸注射剂

药品介绍

瑞士Teoxane生产，相比其他NAHA填充剂含更少蛋白质和细菌内毒素成分，因而更少刺激性和副反应。

Teosyal目前美国尚未应用的，由teoxane laboratoris(geneva，switzerland)生产的Teosyal有七种透明质酸基本的真皮填充剂的产品线。透明质酸含质从15～25mg/g，包括交联和非交联构成。设计的这条产品线可以注射于表浅面部至实皮深层。Teosyal纯度高，过敏反应低，水肿和炎症反应最轻。

透明质酸HA作为一种短效的注射填充剂由于其优良的生物相容性、广泛的适应症、效果立竿见影、简单易行等优点，使其成为世界上用量最大的注射美容用品，且其用量保持强劲的上升势头，尤其采用了交联技术延长效果维持时间以后，更受到广大求美者的青睐。

至目前，在美国有10种透明质酸填充剂（Restylane,Perlane, Juvederm Ultra, Juvederm Ultra Plus, Elevess, Prevelle Silk, Hylaform, Hylaform Plus, and Captique，Puragen Plus）通过了FDA认证并用于临床。

填充剂产品在美国上市，其安全性须经FDA审核，医疗设备要获FDA的批准，必须有大量的欧洲和亚洲的试验数据证实其安全性和有效性，耗时长，这使得美国市场上可供选择的注射美容产品较少，但保证了其质量。相对而言，欧洲和英国的注射美容产品面市就没这么难，只要获得医药设备主管部门（Medical Device Directive）的CE批号（CE marking），即可在欧洲和英国及一些亚洲国家，比如新加坡面市。然而，当一些欧洲填充物起初被认为是高安全性产品，之后证明有副作用时，严格的FDA准则就体现了其严密性。

 
药品规格：
·1支 x 3ml  预充式
·15mg/ml  2支 x 1ml  预充式(Meso 30/32 G 1ml)
·20mg/ml  2支 x 0.7ml  预充式(First Lines)
·25mg/ml  2支 x 0.5ml  预充式(Touch Up 30 G 0.5ml)
·25mg/ml  2支 x 1.2ml  预充式(Ultra Deep 26/28 G 1ml)
·25mg/ml  2支 x 1ml  预充式(Global Action 30 G 1ml)
·25mg/ml  2支 x 1ml  预充式(Deep Lines 27 G 1ml)
·25mg/ml  2支 x 1ml  预充式(Kiss 27 G 1ml)

Teosyal ®
Product Summary
Effective, Long-Lasting and Safe - The Teosyal® range, manufactured in Switzerland by Teoxane Laboratories and distributed in the UK by Lifestyle Aesthetics, consists of several monophasic hyaluronic acid based products of non-animal origin, which are highly biocompatible, offering patients immediate and long-lasting results. The patented technology used in the Teosyal® range has a reduced protein and bacterial endotoxin level resulting in less hypersensitivity reactions. 

Certain products in the Teosyal® range are now delivered with 25g Ultra Thin Wall needles.

Reduction from 20% to 50% of needed force to inject Teosyal dermal filler implants compare to current needles, meaning more comfort for the practitioner.
Use of a 27G needle with Teosyal Ultra Deep instead of current 25G, which reduces the patient trauma during the injection.
Excellent skin penetration thanks to the double bevel design of the extremity and the lubrication of the needles.
Teosyal® was launched in the UK in 2005.

Generic name
Non animal stabilized hyaluronic acid.

How is it made?
By bacterial fermentation from streptococci bacteria.

Is a skin test required before treatment?
No.  The Hyaluronic Acid is 100% non-animal origin and non-allergenic, no allergy test is required prior to injection.

Is it temporary or permanent?
Hyaluronic acid is completely broken down within the skin over a period of months, eventually leaving no trace of the filler.

Licenced status
Medical device.

Should be used by
Trained members of the medical profession only.

Product range

Teosyal Global Action (30G½ )
25mg/ml of HA, 2 x 1ml syringes per box.  Ultra Thin Wall Needles which offers an injection comfort similar to standard 28G needle. 

It is injected into the mid-dermal layer and is suitable for mild to moderate wrinkles of the face; nasolabial lines, glabellar (frown) lines and periorbital and perioral areas.

Teosyal Touch Up (30G)
25mg/ml of HA, 2 x 0.5ml syringes per box.

Designed for touch-up sessions when completing Teosyal Global  Action treatments.

Teosyal First Lines (30G)
20mg/ml of HA, 2 x 0.7ml syringes per box.

It is injected into the surperficial dermis and is recommended for the treatment of fine lines and superficial wrinkles (such as crow`s feet).

Teosyal Deep Lines (27G½)
25mg/ml of HA, 2x 1ml syringes per box.  Ultra Thin Wall Needles which offers an injection comfort similar to standard 25G needle.

It is injected into the mid to deep-dermal layer and is a dense and voluminous implant used to treat deep nasal furrows, lip augmentation and the facial contours of the cheeks and jaw line. It is injected into the deeper layers of the dermis.

Teosyal Kiss (27G½)
25mg/ml of HA, 2 x 1ml syringes per box.  Ultra Thin Wall Needles which offers an injection comfort similar to standard 25G needle.

Teosyal Kiss is highly viscous and boasts high filling power for the lips. It is designed for reshaping lip contours, increasing lip volume, treating wrinkles around the mouth, supporting lip corners and rehydrating the lips.

Teosyal Ultra Deep (27G½)
25mg/ml of HA, 2 x 1ml syringes per box.  Ultra Thin Wall Needles which offers an injection comfort similar to standard 25G needle.

It is injected into the deep-dermal layer and is the Teosyal range’s densest product, achieving an immediate volume-boosting effect. It is designed for creating or restoring facial volumes, resculpting facial contours, treating deep wrinkles in thick skin, erasing folds in the skin, correcting minor ptoses and restoring the face’s original curves.  An Independent study managed by S.J. Falcone et al, and published in Dematological Surgery (2009),  has shown that Teosyal® Ultra Deep is the longest lasting filler on the market, among 18 commercialized dermal fillers.   

Teosyal Ultimate (23G)
22mg/ml of HA, 1 x 3ml syringes per box.

It is injected into the sub-dermal layer and is recommended for remodelling faces requiring large volumes of product. It is designed to create volume in the upper cheeks, cheeks and chin and for correcting deep skin depressions. It is the newest addition to the Teosyal® range.

Teosyal Meso (30/32G)
15mg/ml of HA, 2 x 1ml syringes per box.

It is injected into the superficial dermis and is recommended for the rehydration of the dermis (of the skin), on the face, neck, hands and décolleté.

For more information, please our Teosyal Meso page.

The new complete Teosyal® PureSense range with Lidocaine is now available in the UK.

The latest Teosyal® Hyaluronic Acid gels are extremely pure, monophasic and homogeneous, and therefore are less vulnerable to free radical degradation.  The painless hyaluronic acid injections* use a formula including a local anaesthetic which is recognised worldwide in medicine and surgery: lidocaine.

*Multicentre study France 2010 carried out on 32 patients by Drs Trevidic and Claude, specialists in Plastic, Reconstructive and Cosmetic Surgery.  9/10 patients found the injection significantly less painful than an injection not containing lidocaine.  The study also found than 99% of patients who were injected with PurseSense were willing to be injected again.

Offered with a glass syringe and made from non-animal biodegradable gels, the complete PureSense product range have a greater volume creating ability and can last up to 18 months.

All the products listed below are now available with lidocaine as part of the PureSense range, for more information on the range please see above.

Teosyal PureSense Ultimate, Intense Volume - The longest lasting filler on the market now exclusively available in a 3ml syringe to treat the entire face.

Teosyal PureSense Ultra Deep - The gentle way to give volume

Teosyal PureSense Kiss - Specially formulated for Lip Enhancement

Teosyal PureSense Deep Lines - For in-depth filling

Teosyal PureSense Global Action - For simplified filling

Teosyal First Lines - To treat soft lines

Not to be used in
Individuals with a known hypersensitivity to hyaluronic acid.

Pregnancy and breast feeding.

Duration of effect
This depends upon the degree of correction required, your age and lifestyle as well as the correct placement of the product by a practitioner.

Trials indicate that the majority of the Teosyal® range is effective for an average of 6 to 9 months for the treatment of wrinkles.

An independent study managed by S.J. Falcone et al, and published in Dematological Surgery (2009), shows that Teosyal® Ultra Deep is the longest lasting filler on the market, among 18 commercialized dermal fillers.  The study found that Teosyal® Ultra Deep came number 1 in the prediction of persistence for polysaccharide dermal fillers based on the filler formulation concentration and elasticity as measured according to the tan (0.149 for Ultra Deep) Fillers with higher concentration and higher elasticity are predicted to be more persistent and effective.  This information was declared as the results of an independent study and not sponsered by Teoxane.  

Teosyal® Kiss is manufactured in such as way as to obtain a longer-lasting effect - averaging 9 to 12 months, Teosyal® Ultra Deep is said to last 12 months on average, with Teosyal® Ultimate quoted as a 12 to 18 month average duration; these are according to the manufacturers.

Reported side effects
Transient erythema (redness), swelling, possible discomfort at the implant site, this usually resolves in a few days. Any persistent reaction must be reported to your practitioner.

Costs
This depends on area treated, the specific product used and how much is required, and the practitioner doing the treatment, but ranges are in the region of: to £400 per treatment.