Flomax一般治疗前列腺增大（良性前列腺增生症;良性前列腺增生症） 。也可用于医生确诊的其他病症。 Flomax是一个α -受体阻滞剂。它的工作原理是放松前列腺癌和膀胱癌的肌肉，这有助于改善尿流，减少前列腺增生的症状。
【药理作用】
坦索罗新是新型 α 受体阻滞剂，可选择性地阻断膀胱颈、前列腺腺体及被膜的平滑肌 α1 受体，降低平滑肌张力，降低下尿路阻力，从而改善因前列腺肥大引起的排尿障碍。
动物买验证明，坦索罗新可选择性地阻断大鼠、兔的肾上腺素 α1 受体。其作用比哌唑嗪强 12—22 倍 , 比酚妥拉明强 45—140 倍。对人及动物尿道、膀胱和前列腺的 α1 受体阻断作用 , 比哌唑嗪强 2.2—98 倍，比酚妥拉明强 40-320 倍。麻醉犬研究显示，坦索罗新可明显降低前列腺部位的压力，但对麻醉大鼠节律性膀胱收缩及膀胱内压力无明显影响。

【适应症】
主要用于因前列腺增生所致的排尿障碍等症状，如尿频，夜尿增多、排尿困难等。由于本品是通过改善尿道、膀胱颈及前列腺部位平滑肌功能而达到治疗目的，并非缩小增生腺体，故适用于轻、中度患者及未导致严重排尿障碍者 t 如已发生严重尿潴留时不应单独服用本品。

临床应用:
本品治疗良性前列腺增生的突出优点是起效快、副反应低、复发率低。
美国两大医疗中心应用本品（剂量为 0.4mg 或 0.8mg ）治疗 1488 例 BPH 患者的研究表明，本品的疗效和安全性均佳。可增加尿流率，减少残余尿量，改善 IPSS 评分和生活质量。本品副作用发生率极低，头晕和恶心偶有发生，但均可耐受。
1 ）与非那雄胺比较： 一项多中心、双盲试验，将患有下尿路综合征 / 良性前列腺增生患者随机分为 2 组，其中共有 204 例服用非那雄胺 5mg ，每天 1 次，另一组共有 199 例服用坦索罗辛 0.4mg ，每天 1 次，连续服药 26 周。与非那雄胺相比，坦索罗辛能较迅速地改善尿路症状及增加尿流率。在对照试验中，两者均显示出良好的耐受性。
2 ）与酚苄明相比：本品的作用也与酚苄明相似，但因其为选择性 α-1 受体阻滞剂，对心脏的影响较小，副作用较酚苄明也少。而使用酚苄明的病人约 30% 出现副反应，主要有体位性低血压、心动过速、鼻塞等。

Tamsulosin (rINN) is an α1a-selective alpha blocker used in the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin was developed by Yamanouchi Pharmaceuticals (now part of Astellas Pharma) and is marketed by various companies under licence, including Boehringer-Ingelheim and CSL. Tamsulosin hydrochloride extended-release capsules are marketed under the trade names Flomax, Flomaxtra and Urimax, though generic non-modified release capsules are still approved and marketed in many countries, such as Canada. The U.S. patent for Flomax is set to expire October 2009.
Mechanism
Main article: Alpha blocker
Tamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A receptor in the prostate versus the α1B receptor in the blood vessels.
Clinical uses
Tamsulosin is primarily used for benign prostatic hyperplasia, but is sometimes used for the passage of kidney stones by the same mechanism of smooth muscle relaxation via alpha antagonism.
Adverse effects
Two ADRs (Adverse Drug Reactions) have been reported:
Immunologic: It contains a sulfa moiety, thus causing typical reactions to sulfa drugs.
Ophthalmologic: Patients taking tamsulosin are prone to a complication known as floppy iris syndrome during cataract surgery. Adverse outcomes of the surgery are greatly reduced by the surgeon's prior knowledge of the patient's history with this drug, and thus having the option of alternative techniques.
Tamsulosin has also affected the sexual function in men. Tamsulosin can cause males to experience retrograde ejaculation. In males, retrograde ejaculation occurs when the fluid to be ejaculated, which would normally exit the body via the urethra, is redirected to the urinary bladder. Normally, the sphincter of the bladder contracts and the ejaculate goes to the urethra, the area of least pressure. In retrograde ejaculation, this sphincter does not function properly. Occasionally, tamsulosin can cause a drop in blood pressure, rarely resulting in dizziness or fainting. Other reported side effects include headache, dizziness, nasal congestion, and palpitations.
 Clinical comparison
Although prostate specific, it does not have the prostate apoptotic effects of other alpha-blockers such as doxazosin and terazosin.
Use in Combination Therapy
The results of the CombAT (Combination of Avodart and Tamsulosin) trial have recently demonstrated that treatment with the combination of dutasteride and tamsulosin provides superior symptom benefits compared with either monotherapy.
----------------------------------------------------------------
原产地英文商品名:
Flomax 0.4 mg/capusle 30 capusles/bottle
原产地英文药品名:
Tamsulosin
中文参考商品译名:
Flomax 0.4毫克/粒 30粒/瓶
中文参考药品译名:
坦索罗新
产地国家: 加拿大
所属类别: 泌尿生殖系统及泌乳药物->前列腺疾病用药
处方药:处方药
包装规格: 0.4毫克/粒 30粒/瓶
计价单位: 瓶

----------------------------------------------------------------

原产地英文商品名:
Generic Flomax 0.4 mg/capusle 30 capusles/bottle
原产地英文药品名:
Tamsulosin
中文参考商品译名:
Flomax仿制药 0.4毫克/粒 30粒/瓶
中文参考药品译名:
坦索罗新
产地国家: 加拿大
所属类别: 泌尿生殖系统及泌乳药物->前列腺疾病用药
处方药:处方药
包装规格: 0.4毫克/粒 30粒/瓶
计价单位: 瓶