英文药名: Protonix(pantoprazole tablets)
中文药名: 泮托拉唑片,潘妥洛克
药品名称
药物名称：泮立苏
英文名：Pantoprazole
别名：泮托拉唑, 潘克洛克
外文名：pantoprazole, Protonix
成分：泮托拉唑
适应症
与其它抗菌药物（克拉霉素、阿莫西林和甲硝唑）伍用能够根除幽门螺杆菌感染。十二指肠溃疡，胃溃疡，中、重度反流性食管炎。
规格
20mg, 40mg.
用法用量
本品应在医生指导下服用，每日早晨饭前口服一粒。
十二指肠溃疡疗程通常为2-4周，胃溃疡，反流性食管炎疗程通常为4 周。必要时请继续服用。
本品个体差异小，老年患者无需调整剂量。
伴有幽门螺杆菌感染的十二指肠溃疡或胃溃疡的联合疗法: 本药40mg bid+阿莫西林 1 g bid+克拉霉素500 mg bid；或本药 40 mg bid+甲硝唑 500 mg bid+克拉霉素 500 mg bid；或本药 40 mg bid+阿莫西林 1 g bid+甲硝唑 500 mg bid, 一般持续7天。
其它十二指肠、胃溃疡、反流性食管炎40 mg qd。
个别病例，特别在其它治疗方法无效的情况下，可将剂量加倍。
肾功能受损和老年患者: 剂量不宜超过40mg/日。
严重肝衰竭的患者40 mg，隔日1次。
任何疑问, 请遵医嘱!
不良反应
偶尔引起头痛和腹泻。极少引起恶心、上腹痛、腹胀、皮疹、皮肤瘙痒及头晕。个别病例出现水肿、发热和一过性视力障碍（视物模糊）。
注意事项
重度肝功能不全的患者慎用。
本药不用于治疗病变轻微的胃肠道疾患，如神经性消化不良。在治疗胃溃疡前，须除外胃与食道的恶性病变。反流性食管炎应经胃镜确诊。
妊娠和哺乳妇女慎用。
药物相互作用
本药可能减少生物利用度取决于胃PH值药物（如酮康唑）的吸收。凡通过细胞色素P450酶系代谢的其它药物均不能除外与本药有相互作用的可能性。
包装规格：
·20mg *30片（Nycomed生产）
·40mg *30片（Nycomed生产）
·20mg *84片
·40mg *90 片
Protonix
Generic name: Pantoprazole sodium
Why is Protonix prescribed?
Protonix blocks the production of stomach acid. It is prescribed to heal a condition called erosive esophagitis (a severe inflammation of the passage to the stomach) brought on by a persistent backflow of stomach acid (gastroesophageal reflux disease). Later, it may be prescribed to maintain healing and prevent a relapse. It is also used in the treatment of conditions marked by constant overproduction of stomach acid, such as Zollinger-Ellison syndrome.
Protonix is a member of the "proton pump inhibitor" class of acid blockers.
Most important fact about Protonix
Protonix is highly effective. In most patients, stomach acid secretion drops 85 to 95 percent after a single week of treatment.
How should you take Protonix?
Protonix may be taken with or without food. Do not chew, crush, or split the delayed-release tablets. If you are taking antacids you may continue to do so.
If you miss a dose...
Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take two doses at once.
Storage instructions...
Store Protonix at room temperature.
What side effects may occur?
If Protonix gives you an allergic reaction, you'll be unable to use it.
Special warnings about Protonix
Protonix has been known to cause several extremely rare—but very serious—side effects, including severe allergic reaction, severe swelling of the face and throat, eye damage, dangerous skin reactions, and inflammation of the pancreas. Seek emergency care immediately if you begin to have difficulty breathing or swallowing, or begin to develop blisters, eruptions, or peeling skin.
If you have a liver condition, make sure the doctor is aware of it. A dosage adjustment may be needed for anyone with serious liver disease.
Protonix has not been tested for safety or effectiveness in children.
Possible food and drug interactions when taking Protonix
If Protonix is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Protonix with the following:
Ampicillin
Iron
Ketoconazole
Warfarin
Special information if you are pregnant or breastfeeding
Although no harmful effects during pregnancy are known, there's no definite proof of safety either. Protonix is therefore recommended during pregnancy only if clearly needed. If you are pregnant or plan to become pregnant, inform your doctor immediately.
There is a possibility that Protonix may appear in breast milk, causing serious side effects in the nursing infant. If you have to take the drug, you should not plan on breastfeeding.
Recommended dosage for Protonix
ADULTS
Erosive Esophagitis
The usual dose is 40 milligrams once a day for up to 8 weeks. If your esophagus hasn't healed in that time, your doctor may prescribe an additional 8-week course of therapy. The same dose is used to maintain healing.
Overproduction of Stomach Acid
The usual starting dose is 40 milligrams twice a day. The doctor may increase the dose if necessary. Doses as high as 240 milligrams per day have been used. Treatment may continue for years.
Overdosage
Any medication taken in excess can have serious consequences. Although little is known about Protonix overdose in humans, in animal studies it interferes with coordination and reduces activity. If you suspect an overdose, seek medical attention immediately.