英文药名: Teveten(Eprosartan Tablets)

中文药名: 依普罗沙坦片

品牌药生产厂家: Solvay Pharma
药品名称

中文通用名称: 依普罗沙坦
英文通用名称: Eprosartan, Teveten
其 它 名 称: 依普沙坦, 依普沙坦片, Eprosartan Tablets, 泰絡欣
产 品 分 类: 西药\心血管系统用药\降血压药\肾素－血管紧张素系统抑制药\血管紧张素Ⅱ受体阻滞药

规格: 甲磺酸依普罗沙坦片(1)400mg。(2)600mg。

适应症

用于原发性高血压，可单独用作一线治疗或与噻嗪类利尿药联用(国外资料)。
用法用量

[国外用法用量参考]
成人
•常规剂量
•口服给药原发性高血压：
(1)无血容量不足的患者单用本药治疗的常用初始剂量为一次600mg，一日1次。一日给药总量为400-800mg，分1-2次服用。剂量超过800mg的使用经验有限。
(2)对波谷时测量血压无充分治疗反应的患者，一日2次的给药方案或增加剂量可能产生更佳的抗高血压作用，2-3周可能达到最大降压效应。
(3)一日400-800mg，1次或分2次服用，对降低坐位舒张压至目标水平的疗效相似。
•肾功能不全时剂量
(1)轻度肾脏损害者不必调整初始剂量。
(2)中、重度肾脏损害者对本药的平均肾清除率下降40%-95%，必须调整剂量。
•肝功能不全时剂量
肝脏损害者不必调整初始剂量。
•老年人剂量
(1)不必调整初始剂量。
(2)一项对65-90岁老人的研究提示，一次100-200mg，一日2次，安全而有效。
任何疑问, 请遵医嘱!
不良反应

[国外不良反应参考]
1.心血管系统血管紧张素Ⅱ受体拮抗药(ARA)可致麻醉时低血压发生增多。试验发现，与ACEI(n=27)、β肾上腺素受体阻断药或钙通道拮抗药(n=45)比较，长期使用ARA的患者(n=12)在血管外科手术麻醉诱导后低血压的发生率和严重程度均显著增加，同时也需要更大的麻黄碱剂量来恢复血压水平。
2.中枢神经系统据报道，最常见头痛(3.8%)、眩晕(2.4%)和疲乏(1.4%)，但总发生率与使用安慰剂无显著差异。
3.代谢/内分泌系统
(1)有报道，使用本药每日600mg，不改变轻中度原发性高血压患者的尿酸/肌酸酐(Ur/Cr)比率、尿酸的排泄或血尿酸水平。
(2)男性轻度高血压患者(n=57)使用本药一日50-1200mg，疗程1周，无论单剂或多剂给药均对血尿酸或尿酸的分级排泄无影响。
4.呼吸系统临床试验中出现咳嗽(1.8%-6.5%)，但发生率与安慰剂对照组无显著差异。
5.肌肉骨骼系统临床试验中有肌痛(1.9%)的报道，但总发生率与安慰剂组无显著差异。
6.皮肤可见面部水肿。
注意事项

1.禁忌症
(1)对本药过敏者(国外资料)。
(2)孕妇(国外资料)。
2.慎用
(1)有血管紧张素转换酶抑制药(ACEI)、阿司匹林、青霉素过敏史。
(2)主动脉瓣(或二尖瓣)狭窄或肥厚型心肌病。
(3)低血压。
(4)肝功能不全、胆汁性肝硬化或胆道梗阻。
(5)肾功能不全或肾动脉狭窄(单侧肾或双侧肾)。
(6)高钾血症。
(7)需全身麻醉的外科手术。(以上均选自国外资料)
3.药物对老人的影响老年人对本药的吸收增加，大于65岁老年人的曲线下面积(AUC)和Cmax约增加2倍。
4.药物对妊娠的影响美国食品药品管理局(FDA)对本药的妊娠安全性分级为C级(妊娠早期)和D级(妊娠中晚期)。如发现使用本药治疗的患者开始妊娠，应停用本药并换用其他药物。如不能选择其他抗高血压药物，应告知患者继续治疗的风险，同时应经常做超声波检查，并监测患者是否出现羊水过少。
5.药物对哺乳的影响尚不明确本药是否经乳汁分泌。
包装规格：
300mg *84 片
400mg *56 片
600mg *28  片

Teveten (Eprosartan Mesylate)
Teveten (eprosartan mesylate) is generally used to treat the arterial hypertension and maintain the blood pressure in normal and safe limits. The hypertension is defined as an increase of the sanguine pressure in the systemic circulation, regardless of the causes. The specialist doctors consider 110 and 140 mm Hg as safe limits for the systolic pressure and 65 and 90 mm Hg for the diastolic pressure. The hypertension can cause a lot of complications if not treated, especially to the cardiac system. However, this is not the most dangerous part. The dangerous aspect of this condition is that it is asymptomatic, so it is very hard to observe it. It is normally noticed at a routine control or when it becomes so severe that the patient can experience various symptoms. In order to diagnose it, the patient must go through at least 3 different consultations. If the doctor observes an abnormal value for the hypertension for 3 times in a row, the diagnostic may be set. Sometimes, the treatment for arterial hypertension is short term, while other times it might be lifetime. This condition is not actually a disease, but often the symptom of another disease or the side effect of a medication. Therefore, this treatment is usually associated with the drugs needed to cure the causing condition.
Teveten (eprosartan mesylate) is an angiotensin II receptor antagonist and prevents the blood vessels from constricting. This aspect prevents the hypertension and improves the flow. The medication has initially hit the market in 1997. It was immediately approved by the FDA due to its beneficial effects. It cannot be taken without a prescription from your doctor.
Administration
The starting Teveten (eprosartan mesylate) dose is 600mg a day when used in single therapies. If used in associated therapies, the daily dose might be split in more smaller doses. However, the daily amount of medicine ranges between 400mg and 800mg. The 800mg dosage is actually the maximum recommended one due to the lack of conclusive tests for higher amounts. The dosage is often adjusted, according to your clinical response.
The Teveten (eprosartan mesylate) tablets are taken whole, with water and with or without food.
Your specialist doctor will check your blood pressure on a regular basis throughout the Teveten (eprosartan mesylate) treatment, to make sure it actually works. It usually takes a few weeks before you can notice any beneficial effects. If you miss a dose, never double up the next one, but call your doctor instead. A Teveten (eprosartan mesylate) overdose symptoms include passing out sensations and dizziness.