英文药名: Betagan(Levobunolol Eye Solution)

中文药名: 左布诺洛尔眼液

品牌药生产厂家: Allergan

药品名称

通用名：盐酸左布诺洛尔滴眼液
英文名：Levobunolol Hydrochloride Ophthalmic Solution
商品名：BETAGAN贝他根
主要成分：本品主要成份为盐酸左布诺洛尔
化学名称：L-5-(3-叔丁氨基-2-羟丙氧基)-3,4-二氧-1(2H)-萘酮盐酸盐
分子式：C17H25NO3?HCl
分子量：327.85
性状：本品为无色或浅黄色的澄明液体。
药理毒理

盐酸左布诺洛尔是一类非心脏选择性β-受体阻滞剂，对β1和β2受体具有同样的作用，左布诺洛尔的阻断β-受体作用比它的右旋异构体强60倍，但直接心肌抑制作用相同，因此左旋异构体-左布诺洛尔被采用。左布诺洛尔无明显局麻作用（膜稳定）或内在拟交感活性。
本品（0.5%盐酸左布诺洛尔）在降低眼内压时与噻吗心安同样有效。
不管是否伴有青光眼，本品对已有眼压升高和眼压正常患者同样具有降眼压作用。眼压升高是青光眼视野缺损的主要危险因素，眼压愈高，视神经及视野损害的可能性愈大。
盐酸左布诺洛尔降眼压最可能的主要机制是降低房水的产生量，本品降低眼压的同时不伴有缩瞳作用，与胆碱能类药物不同，应用本品时不出现与瞳孔缩小有关的视物模糊及夜盲。白内障患者晶体透光度差，瞳孔收缩可使视物能力进一步下降，而本品可避免此现象的产生。
约两年的临床对照研究显示：每日两次的本品可使近80%的患者眼压下降，与基线对照平均眼压下降6.87mmHg至7.81mmHg。对瞳孔大小无影响，无流泪或角膜刺激症状。局部使用该浓度本品，部分患者可出现心率及血压下降。在整个研究过程中，本品能维持较好的降眼压作用。
药代动力学

滴入1滴本品一小时内可检测到其药物作用，2～6小时作用达高峰，一次用药后，显著药物作用可维持24小时。
适应症

用于慢性开角型青光眼及高眼压症患者的眼内压控制。
用法用量

1滴，bid.
任何疑问，请遵医嘱！
禁忌

支气管哮喘或有支气管哮喘史的患者，严重的慢性阻塞性肺部疾病，窦性心动过缓，ⅡⅢ度房室传导阻滞，明显的心衰，心源性休克。
不良反应

睑结膜炎，一过性眼烧灼，刺激感，心率下降。
注意事项

肺功能低下的患者慎用。戴软性角膜接触者不宜使用。
药物相互作用

可加强全身性降压药的作用。
储藏

避光，15～25℃保存。
包装规格：

0.50% 1支 x 5ml 
0.50% 1支 x 10ml 

Medication name
Generic name: Levobunolol - Ophthalmic
Brand name(s): Betagan
Uses
This medication is used alone or with other medications to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (e.g., ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness. Levobunolol belongs to a class of drugs known as beta blockers and works by decreasing the amount of fluid production within the eye.
How to use
To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.If you are wearing contact lenses, remove them before using eye drops. Wait at least 15 minutes before replacing your contact lenses.Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch, usually once or twice daily or as directed by your doctor. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed or if your dose is for more than 1 drop.Do not rinse the dropper. Replace the dropper cap after each use.If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 to 10 minutes before using the other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. It is important to continue using this medication even if you feel well. Most people with glaucoma or high pressure in the eyes do not feel sick.
Precautions
Before using levobunolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (e.g., timolol, metipranolol); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride, sulfites), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., asthma or a history of asthma, chronic obstructive pulmonary disease-COPD), certain types of heart rhythm problems (e.g., sinus bradycardia, second- or third-degree atrioventricular block), certain serious heart conditions (e.g., cardiogenic shock, severe heart failure).Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., bronchitis, emphysema), diabetes, heart failure (treated, stable type), blood circulation problems (e.g., cerebrovascular insufficiency), overactive thyroid (hyperthyroidism), muscle weakness disorders (e.g., myasthenia gravis).Before having surgery, tell your doctor or dentist that you are using this medication.This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.If you have diabetes, this product may mask the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of a low blood sugar level, such as dizziness/sweating, are unaffected by this drug.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: certain diabetes drugs (e.g., insulin, sulfonylureas such as glyburide), digoxin, drugs for high blood pressure (e.g., clonidine, reserpine, oral beta blockers such as propranolol, calcium channel blockers such as diltiazem), epinephrine, phenothiazines (e.g., prochlorperazine).This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
Side effects
Temporary burning/stinging of the eye, itchy/red eyes, headache, or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: eye pain/swelling/discharge, reduced feeling in eye, slow/irregular heartbeat, muscle weakness, hair loss, mental/mood changes, vision changes, tiredness, swelling of the ankles/feet, sudden/unexplained weight gain.Seek immediate medical attention if any of these rare but very serious side effects occur: trouble breathing, chest pain, weakness on one side of the body, slurred speech, confusion.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Missed dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Overdose
This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact your local poison control center or emergency room immediately. US residents should call the US National Poison Hotline at 1-800-222-1222. Canada residents should call a provincial poison control center. If this product is accidentally swallowed, you may experience symptoms such as trouble breathing, slow/irregular heartbeat.
Notes
Do not share this medication with others.Laboratory and/or medical tests (e.g., eye exams) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
Storage
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
 
Betagan 0.5 % Eye Drops