部分中文乐沙定处方资料（仅供参考）

乐沙定（奥沙利铂）集中解决方案，静脉注射使用
最初美国批准：2002
赛诺菲 - 安万特美国公司

请参阅完整的处方资料完整的黑框警告。

Eloxatin的过敏反应报告，并可能发生的几分钟内Eloxatin的管理。已受聘肾上腺素，糖皮质激素，抗组胺药，以减轻症状。
Eloxatin的过敏反应报告，并可能发生的几分钟内Eloxatin的管理。已受聘肾上腺素，糖皮质激素，抗组胺药，以减轻症状。
有过敏性反应，以Eloxatin的报道，并可能发生几分钟内Eloxatin的管理。已受聘肾上腺素，糖皮质激素，抗组胺药，以减轻症状。

最近的重大变化
剂量和用法
警告及注意事项
 
适应症
Eloxatin的是铂类为基础的药物结合使用静脉滴注5 - 氟尿嘧啶/亚叶酸钙，表示：

谁经历了原发肿瘤完全切除的患者的III期结肠癌的辅助治疗。
治疗晚期大肠癌。
 
剂量和用法
管理的结合5-fluorouracil/leucovorin每2周的Eloxatin的。

第1天：Eloxatin的85 mg/m2的250-500毫升5％葡萄糖注射液中静脉滴注，USPand亚叶酸钙200 mg/m2静脉滴注5％葡萄糖注射液，美国药典都定在同一时间超过120分钟，在单独使用一个Y袋行，其次是5-氟脲嘧啶400 mg/m2的静脉注射超过2-4分钟，其次为22小时连续在500毫升5％葡萄糖注射液，USP（推荐），5 -氟脲嘧啶600 mg/m2静脉滴注输液。

第2天：亚叶酸钙200 mg/m2静脉滴注超过120分钟，5-氟脲嘧啶400 mg/m2的静脉注射超过2-4分钟，5 - 氟脲嘧啶600 mg/m2的500毫升5％葡萄糖注射液中静脉滴注作为一个22小时连续输注，美国药典（推荐）。
Eloxatin的减少剂量为75 mg/m2（辅助设置）或65 mg/m2的（晚期大肠癌）：

如果有持续2级神经性事件，不解决。

恢复后，从3/4级胃肠道毒性（尽管预防性治疗）或4级中性粒细胞减少或等级3/4血小板减少。延迟下一次剂量，直到中性粒细胞≥1.5×109 / L，血小板≥75×109 / L。
对于严重肾功能不全患者（肌酐清除率<30毫升/分钟），建议初始剂量为65 mg/m2的。
停止Eloxatin的，如果有持久三级神经性事件。
从来没有重组或准备与氯化钠溶液或其他含有氯化物的溶液最后稀释。
 
剂型和优势
为无菌，无防腐剂的重建冻干粉50毫克或100毫克奥沙利单次使用的小瓶。
单次使用的小瓶50毫克，100毫克或200毫克草酸铂，无菌，无防腐剂，在5毫克/毫升的浓度的水溶液。
 
禁忌
Eloxatin的或其他铂化合物已知过敏。
 
注意事项：
过敏反应：皮疹，荨麻疹，红斑，瘙痒，支气管痉挛和低血压的发展监视器。
神经病：减少剂量或停止Eloxatin的，如果必要。
肺毒性：可能需要停止Eloxatin的间质性肺疾病或肺间质纤维化，直到排除。
肝毒性：监测肝功能试验。
怀孕。管理到孕妇时可能发生的胎儿造成伤害。妇女应告知对胎儿的潜在危害。
 
不良反应
最常见的不良反应（发生率≥40％），周边感觉神经病变，中性粒细胞，血小板减少，贫血，恶心，转氨酶和碱性磷酸酶增加，腹泻，呕吐，疲劳和口腔炎。其他不良反应，包括严重的不良反应，已有报道。
 
日期：02/2012
Eloxatin
Generic Name: oxaliplatin (ox AL ih plat in)
Brand Names: Eloxatin
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What is Eloxatin?
Eloxatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. It is an antineoplastic and works by killing cancer cells and slowing tumor growth.
Eloxatin is used together with other cancer medications to treat colon and rectal cancer.
Eloxatin may also be used for other purposes not listed in this guide.
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Important information about Eloxatin
Do not use Eloxatin without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. You should not receive Eloxatin if you are allergic to oxaliplatin or similar medications such as carboplatin (Paraplatin) or cisplatin (Platinol).
Before receiving Eloxatin, tell your doctor if you are allergic to any drugs, or if you have liver disease, asthma, or a nerve problem.
Receiving Eloxatin can make you more sensitive to cold. This includes exposure to cold temperature and coming into contact with cold objects. To prevent discomfort avoid breathing in cold air, cover your skin in cold weather, wear gloves when handling cold objects, avoid air conditioning, and do not use ice or drink cold beverages.
Do not eat ice chips to ease mouth sores or nausea because you will be more sensitive to cold. Talk to your doctor about other ways to treat nausea or mouth sores.
Call your doctor if you have a serious side effect such as numbness or tingling, problems with speech or swallowing, chest tightness, fever with diarrhea or vomiting, increased thirst, decreased urination, easy bruising or bleeding, weakness, or mouth sores.
Eloxatin can lower blood cells that help your body fight infections. This can make it easier for you to bleed or get sick. Avoid being around others who are ill. Your blood will need to be tested on a regular basis. Your kidney and liver function may also need to be tested. Do not miss any scheduled appointments.
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Before receiving Eloxatin
You should not receive Eloxatin if you are allergic to oxaliplatin or similar medications such as carboplatin (Paraplatin) or cisplatin (Platinol).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely receive Eloxatin:
liver disease;
asthma or other breathing disorder; or
a nerve problem.
FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not receive Eloxatin without telling your doctor if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. It is not known whether Eloxatin passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.
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How is Eloxatin given?
Eloxatin is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take up at least 2 hours to complete.
Eloxatin is usually given as part of a 2-day treatment every 2 weeks. Follow your doctor's instructions.
Receiving Eloxatin can make you more sensitive to cold. This includes exposure to cold temperature and coming into contact with cold objects. To prevent discomfort, follow these steps:
do not inhale deeply when you are exposed to cold air;
cover your skin, head, and face when you are outside in cold temperatures;
wear gloves when handling cold objects or refrigerated foods;
do not run an air conditioner at very cool temperature in your home or car (even during hot weather);
do not drink cold drinks or use ice cubes in drinks;
do not put ice packs on your body.
Chemotherapy often causes nausea or mouth sores. Do not eat ice chips to ease these discomforts because you will be more sensitive to cold. Talk to your doctor about other ways to treat nausea or mouth sores. You may be given other medications to prevent nausea or vomiting while you are receiving Eloxatin.
Eloxatin can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your kidney and liver function may also need to be tested. Do not miss any scheduled appointments.
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What happens if I miss a dose?
Contact your doctor if you miss an appointment for your Eloxatin injection.
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What happens if I overdose?
Seek emergency medical attention if you think you have received too much of this medicine.
Overdose symptoms may include easy bruising or bleeding, unusual weakness, severe vomiting or diarrhea, numbness or tingling, flu symptoms, wheezing, trouble breathing, chest pain, slow heart rate, weak or shallow breathing (breathing may stop).
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What should I avoid while using Eloxatin?
Eloxatin can make you more sensitive to cold. Avoid cold temperatures and cold objects, including ice, cold drinks, and skin exposure to cold temperatures.
Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.
Eloxatin can cause side effects that may impair your vision. Be careful if you drive or do anything that requires you to be able to see clearly.
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Eloxatin side effects
Some people receiving a Eloxatin injection have had a reaction to the infusion within minutes after the medicine is injected into the vein. Tell your caregiver right away if you feel short of breath, confused, sweaty, itchy, or have diarrhea, chest pain, warmth or redness in your face, or feel like you might pass out.
Get emergency medical help if you have any of these signs of an allergic reaction to Eloxatin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
numbness or tingly feeling in your hands, feet, throat, and around your mouth;
numbness or burning pain that interferes with daily activities;
increased sensitivity to cold temperatures and cold objects;
jaw or chest tightness, eye pain, strange feeling in your tongue, problems with speech or swallowing;
fever, diarrhea, vomiting, chills, body aches, flu symptoms, sudden cough;
increased thirst, dry mouth, urinating less than usual;
decreased vision;
easy bruising or bleeding, unusual weakness; or
white patches or sores inside your mouth or on your lips.
Less serious Eloxatin side effects may include:
nausea, stomach pain, loss of appetite;
constipation;
tired feeling;
hair loss;
decreased taste sensation;
muscle pain;
headache;
sleep problems (insomnia);
swelling; or
back pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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What other drugs will affect Eloxatin?
Before you receive Eloxatin, tell your doctor if you also take a blood thinner such as warfarin (Coumadin).
There may be other drugs that can interact with Eloxatin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
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Where can I get more information?
Your doctor or pharmacist can provide more information about Eloxatin.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or propriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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原产地英文药品名：
OXALIPLATIN
中文参考药品译名：
奥沙利铂
原产地英文商品名：
ELOXATIN 200mg/40ml/vial
中文参考商品译名：
乐沙定 200毫克/40毫升/瓶
生产厂家英文名：
SANOFI AVENTIS US
生产厂家中文参考译名：
赛诺菲安万特
该药品相关信息网址1：
http://www.drugs.com/eloxatin.html
曾用名：
未知