部分中文奥芬那君处方资料（仅供参考）
 
奥芬那君注射剂|Norflex(Orphenadrine Injection)
 
英文药名: Norflex(Orphenadrine Injection) ；N,N-Dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine 2-hydroxypropane-1,2,3-tricarboxylic acid salt
 
中文参考药名:

奥芬那君注射剂；N,N-二甲基-2-[(2-甲基苯基)苯甲氧基]乙胺 2-羟基-1,2,3-丙三羧酸盐
 
奥芬那君注射剂药品简介
 
枸橼酸奥芬那君（枸橼酸邻甲苯海拉明，柠檬酸邻甲苯海拉明）
 
英文名称：Orphenadrine Citrate(Mephenamine Citrate,Norflex)
 
性状：白色或近白色结晶粉末，几无臭，味苦。溶于水，微溶于乙醇，不溶于氯仿或乙醚。
 
作用机制：
 
本品结构与抗组胺药苯海拉明类似，作用于大脑和脊髓运动中枢，使骨骼肌松驰。本品尚具有较弱的外周抗胆碱和抗胺作用，但镇静作用弱。 本品对痉挛性或运动障碍性运动病无效。
 
药动学：
 
口服吸收较好，大部分被代谢，平均血浆t1/2约为14h。
 
适应症：
 
临床主要用作解除局部肌肉痉挛性疼痛的辅助用药，也常与其他药物联合用于控制动脉硬化引起的特发性或脑炎后的震颤麻痹。
 
注意事项：
 
(1)本品的不良反应主要与其抗胆碱活性有关，常见的有视物模糊，口和皮肤干燥，轻度兴奋。
 
(2)本品标用于闭角型青光眼及重症肌无力患者。心动过速、心功能不全或尿潴留患者慎用。
 
(3)服用本品期间避免进行注意力须高度集中的活动如驾驶、登高、操作精密仪器等。
 
用法用量：
 
口服：成人，100mg/次，2次/d。
 
肌内或静脉注射，成人，60mg/次，2次/d。
 
制剂：片剂：100mg。注射液：30mg/1ml。
 
GENERIC NAME: ORPHENADRINE - ORAL (or-FEN-uh-dreen)
 
BRAND NAME(S): Norflex

USES: This medication is used to treat pain and discomfort from muscle injuries such as strains, sprains, and spasms. It provides temporary relief and is usually used along with rest, physical therapy, and other treatments (e.g., nonsteroidal anti-inflammatory medication). This medication relaxes tight muscles and relieves pain, cramping, and stiffness so you can move around more and get back to doing your daily activities. Orphenadrine belongs to a class of drugs called muscle relaxants.
 
HOW TO USE: Take this medication by mouth, usually twice daily or as directed by your doctor.Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.The dosage is based on your medical condition and response to therapy. Do not increase your dose, take it more often, or take it for longer than prescribed.Inform your doctor if your condition does not improve or if it worsens.
 
SIDE EFFECTS: Dizziness, lightheadedness, drowsiness, blurred vision, widened pupils, weakness, headache, nausea, vomiting, constipation, and dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., confusion, anxiety, hallucinations), shaking, fast/pounding heartbeat, fainting, difficulty urinating, eye pain.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
 
PRECAUTIONS: Before taking orphenadrine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: high pressure in the eye (glaucoma), stomach/intestinal ulcers or blockage, enlarged prostate, bladder problems, a certain esophagus problem (megaesophagus/cardio-spasm), a certain type of muscle disease (myasthenia gravis).Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (e.g., fast heartbeat, irregular heartbeat, heart failure).This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.The elderly may be more sensitive to the side effects of this drug, especially confusion.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
 
DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: propoxyphene.Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), other muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about using those products safely.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
 
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents should call the US National Poison Hotline at 1-800-222-1222. Canada residents should call a provincial poison control center. Symptoms of overdose may include: unusual excitement, fast/irregular heartbeat, seizures.
 
NOTES: Do not share this medication with others.If you are taking this medication for a long time, laboratory and/or medical tests may be performed periodically to check for side effects. Consult your doctor for more details.
 
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
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原产地英文商品名:
 
NORFLEX 30MG/ML 2ML/AMPUL 6AMPULS/BOX
 
原产地英文药品名:
 
ORPHENADRINE CITRATE
 
原产地英文化合物名称:
 
N,N-Dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine 2-hydroxypropane-1,2,3-tricarboxylic acid salt
 
中文参考商品译名:
 
NORFLEX 30毫克/毫升 2毫升/安醅 6安醅/盒
 
中文参考药品译名:
 
枸橼酸奥芬那君
 
中文参考化合物名称:
 
N,N-二甲基-2-[(2-甲基苯基)苯甲氧基]乙胺 2-羟基-1,2,3-丙三羧酸盐

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原产地英文商品名:
 
NORFLEX 30MG/ML 2ML/AMPUL/BOX
 
原产地英文药品名:
 
ORPHENADRINE CITRATE
 
原产地英文化合物名称:
 
N,N-Dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine 2-hydroxypropane-1,2,3-tricarboxylic acid salt
 
中文参考商品译名:
 
NORFLEX 30毫克/毫升 2毫升/安醅/盒
 
中文参考药品译名:
 
枸橼酸奥芬那君
 
中文参考化合物名称:
 
N,N-二甲基-2-[(2-甲基苯基)苯甲氧基]乙胺 2-羟基-1,2,3-丙三羧酸盐