英文药名：Rapamune (Sirolimus Tablets) 中文药名：西罗莫司片（雷帕霉素） 生产厂家：惠氏公司 分类名称 免疫调节剂免疫抑制剂  药品英文名 Sirolimus 药品别名 雷帕霉素、Rapamycin、RAPAMUNE、RAPMIC  药物剂型 1.性状：为白色结晶状固体，难溶于水，可溶于甲醇、乙醚、丙酮、氯仿等有机溶剂。 2.制剂： 口服液：1mg/ml。 片剂：每片1mg。 药理作用 1.药理： 本品为链霉菌streptomyces hygroscopicus培养液中提取的三烯大环内酯类抗生素，其化学结构与FK-506相似。本品为T细胞抑制剂，具有优于环孢素、FK-506的免疫抑制活性。它进入细胞后与胞浆内FKBs结合，通过抑制丝氨酸/苏氨酸蛋白激酶活性，使40S核糖体蛋白S6不能磷酸化，从而抑制蛋白质合成，阻止T细胞由G1期向S期转变，阻止B细胞的G0期。与环孢素与FK506不同，它不仅抑制Ca2 依赖性T、B细胞活化，也抑制Ca2 不依赖性T、B细胞活化，并可抑制金黄色葡萄球菌引起的B细胞免疫球蛋白的合成及淋巴细胞激活的杀伤细胞(LAK)、自然杀伤细胞(NK)和抗体依赖性细胞毒作用，可治疗和逆转发展中的急性排异反应。由于可抑制生长因子导致的成纤维细胞、内皮细胞、肝细胞和平滑肌细胞的增生，故对预防慢性排异反应也有效。 2.应用： 本药用于器官移植抗排异反应及自身免疫性疾病的治疗。口服后可吸收，片剂和口服液的生物利用度分别为27%和15%。吸收后可分布于组织和血细胞(主要是红细胞)。经肝P4503A代谢。消除半衰期约60小时。 适应证 可用于器官移植抗排异反应及自身免疫性疾病的治疗。 注意事项 可见厌食、腹泻及呕吐，严重者可出现消化性溃疡、间质性肺炎及脉管炎。也可出现贫血、血小板减少症、高脂血症及高血压。 用法用量 口服。一次负荷剂量6mg，随后的维持量为2mg/日。服用口服液时需稀释。 专家点评 本药用于器官移植抗排异反应及自身免疫性疾病的治疗。药物经肝P450 3A代谢。消除半衰期约60小时。器官移植抗排异反应及自身免疫性疾病的治疗时限长，要注意关注出现消化性溃疡、间质性肺炎及脉管炎。贫血、血小板减少症、高脂血症及高血压等付作用。 Rapamune(Sirolimus Tablets) Generic Name: sirolimus Brand Name: Rapamune Rapamune (Sirolimus) Tablets The Rapamune (sirolimus) tablets are indicated in the kidney transplant unexpected situations. Although there are a wide variety of tests performed prior to a transplant in order to make sure the organ is compatible with the organism, a lot of patients encounter problems due to an intense immune system. The organ is new, therefore the immune system considers it to be an intruder. It reacts negatively, leading to many potential complications. In most of the cases, the new organ doesn’t work accordingly and it is almost like not even being there. In order to prevent or to treat such problems, the doctors have multiple options. These tablets work on the immune system, by lowering its activity and intensity. It is a temporary situation that gives your organism time to adopt the new organ. The Rapamune (sirolimus) tablets are indicated in the kidney transplants only. They do not work for other transplants. Since they can be dangerous if used in a wrong manner and to avoid the potential mistakes people can make, the medication is available with a medical prescription only. It is FDA approved since 1999, with the latest formula dating since 2000. It can also be found on the market in a different form – oral suspension. Administration The Rapamune (sirolimus) tablets are taken orally and often in associated therapies with drugs like cyclosporine. The tablets must be swallowed whole and never crushed. You can take them with food or on an empty stomach. Most doctors recommend the empty stomach, although if you present severe gastric or bowel side effects, you can get them with food. It is very important to get them at the same time everyday and stick to the way you start. If you get them on an empty stomach, then go on with this form of administration for as long as the treatment lasts. If you miss one of the Rapamune (sirolimus) tablets, get it as soon as you remember, but not if there are just a few hours until the next dose is scheduled. If you are not sure what to do, just call your doctor. Never double up a dose. Contraindications Wash your hands right after the administration. Never combined the Rapamune (sirolimus) tablets with grapefruit. The results can be quite harmful. Also, since the Rapamune (sirolimus) tablets work on your immune system, try to avoid the people with contagious diseases. You are open to most infections. The same goes for the live vaccines. --------------------------------------------------- 注：以下产品不同规格和不同价格，以咨询为准！ ---------------------------------------------------- 产地国家: 美国 原产地英文商品名: RAPAMUNE 1mg/tablet,100tablets/box 原产地英文药品名: SIROLIMUS 中文参考商品译名: 雷帕鸣 1毫克/片 100片/盒 中文参考药品译名: 西罗莫司片 生产厂家中文参考译名: 惠氏公司 生产厂家英文名: WYETH PHARMS INC ----------------------------------------------------- 产地国家: 美国 原产地英文商品名: RAPAMUNE 2mg/tablet,100tablets/box 原产地英文药品名: SIROLIMUS 中文参考商品译名: 雷帕鸣 2毫克/片 100片/盒 中文参考药品译名: 西罗莫司片 生产厂家中文参考译名: 惠氏公司 生产厂家英文名: WYETH PHARMS INC ----------------------------------------------------- 产地国家: 美国 原产地英文商品名: RAPAMUNE 1MG/ML ORAL SOLN 60ML 原产地英文药品名: SIROLIMUS 中文参考商品译名: 雷帕鸣 1毫克/毫升，60毫升口服溶液/瓶 中文参考药品译名: 西罗莫司 生产厂家中文参考译名: 惠氏公司 生产厂家英文名: WYETH PHARMS INC --------------------------------------------------------- 产地国家: 美国 原产地英文商品名: RAPAMUNE 1 MG TABLET 100'S REDIPACK 10X10'SUD BLISTERPACKS 原产地英文药品名: SIROLIMUS 中文参考商品译名: 雷帕鸣 1毫克，100片/盒 中文参考药品译名: 西罗莫司片 生产厂家中文参考译名: 惠氏公司 生产厂家英文名: WYETH PHARMS INC