【中文品名】盐酸头孢甲肟 【药效类别】抗生素>头孢菌素类 【通用药名】CEFMENOXIME HEMIHYDROCHLORIDE 【别　　名】氨噻肟唑头孢菌素，倍司特克，Bestcall, Bestron, Bestron eye drops, Bestron Otic, Cefmax, Cemix, CMX, Tacef, Abbott-50192, A-50192, SCE-1365, Tacef 【化学名称】 5-Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-, hemihydrochloride 【CA登记号】[75738-58-8] 【结 构 式】 【分 子 式】C16H17N9O5S3·1/2HCl 【分 子 量】529.80 【收录药典】 【开发单位】武田药品工业株式会社 (日本) 【首次上市】1983年，日本 【性　　状】白色或浅橙黄色结晶或结晶性粉末，无具或稍有特殊气味。易溶于二甲亚砜、二甲基甲酰胺，不易溶于甲醇，极难溶于水，几乎不溶于乙醇和丙酮。mp174~175℃(dec)。 【用　　途】 第三代头孢，对革兰氏阴性和阳性的需氧菌和厌氧菌均有抗菌作用。革兰氏阴性菌中，对大肠杆菌、肺炎杆菌的抗菌作用比头孢替安稍强，明显强于第一代的头孢唑啉，对流感噬血杆菌、变形杆菌、粘质沙雷菌、柠檬酸杆菌属、肠杆菌属的抗菌作用也比较强，对拟杆菌属也有很强的抗菌作用。在革兰氏阳性菌中，对化脓性链球菌、肺炎球菌的抗菌作用也较强。对消化球菌属、消化链球菌属也有强大的抗菌作用。对β内酰胺酶稳定。本品对葡萄球菌属的作用不如第一、二代头孢菌素，对绿脓杆菌、肠杆菌和肠球菌作用差。静注1g，血药峰值99.4微克／毫升，肌注0.5g为10．8微克／毫升，血清t1/2为1小时左右。在体内几乎不代谢，主要经肾排泄。血清蛋白结合率85％。本品向胆汁转运良好，在痰液、扁桃体、脑脊髓液、胸水、腹腔渗出液、肾、膀胱壁、子宫、输卵管、卵巢、骨盆腔渗出液、脐带血、羊水等体液及组织分布浓度较高。但向乳汁中转运很少。适用于敏感菌引起的败血症、脑膜炎、呼吸道感染、脓胸、肝及胆感染、腹膜炎、尿道感染、生殖系统感染以及烧伤和手术伤口感染等。 Manufacturer's name : Kyorin Pharmacetical Co.,Ltd 620006516 Newly-created: 07/2008 Brand name : BESTRON FOR EAR AND NOSE 1% (500mg) 　Active ingredient: Cefmenoxime hydrochloride 　Dosage form: colorless to pale yellow limpid topical solution 　Printings on wrapping: cap: white (top of the cap: orange), body: translucent with orange label, ベストロン耳鼻科用1% 局所外用セフメノキシム塩酸塩, 500mg (力価) Effects of this medicine This is cephem antibiotic to inhibit synthesis of bacterial cell walls, and shows bactericidal action. It is usually used in the treatment of otitis externa, otitis media and sinusitis. Before using this medicine, tell your doctor/pharmacist If you ever experienced any allergic reaction (itch, rash etc.) to any medicine. If you are pregnant or breastfeeding. If you are using any other prescription or nonprescription (OTC) medicine. (It is important to reduce the risk of drug interactions.) Dosage regimen (proper use of this medicine) Your dosage regimen is:(order of your doctor) General dosage regimen: For otitis externa and otitis media, dissolve 10 mg (titer) of the medicine per 1 mL of the provided solution. Then instill 6 to 10 drops into the ear canal at a time, twice daily. After instillation, keep the ear facing up for 10 minutes to allow absorption of the medicine. For sinusitis, dissolve 10 mg (titer) of the medicine per 1 mL of the provided solution. Then inhale 2 to 4 mL with a nebulizer at a time, once every other day, 3 times a week, or instill 1 mL into the maxillary sinus, once a week. The dosage may be adjusted according to the diseases or symptoms in any case. Strictly follow the instructions of your doctor/pharmacist. For ear instillation, warm the medicine to room temperature, then lie on your side with the affected ear up. Instill the medicine into the ear canal carefully, not to touch the dropper tip directly the ear and remain still for 10 minutes. Apply clean gauze to the ear and wipe off residual medicine that may drip out of the ear when you sit up. If the medicine too cold to apply, it may cause dizziness. Missed dose: Use a dose as soon as possible when you remember that you missed a dose. However, it is needed to take an interval as long as possible before the next dose. DO NOT use double doses to make up for the missed dose. Overdose: If you used too much of the medicine (more than ordered), check with your doctor/pharmacist. Others: Do not stop using the medicine without the instructions of your doctor. Precautions while using this medicine Side effects of this medicine Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist: (rhinology) wheezing (whistling sound), cough, rhinitis (nasal discharge, sneeze), nausea, vomiting, rash, headache, etc. (otology) eczema in the external auditory canal, ear pain in instilling, rash, etc.In rare cases, symptoms described below may be the sign of side effects indicated in brackets [ ]. If they occur, stop using your medicine and check with your doctor immediately. urticaria, discomfort feeling, dizziness [shock, anaphylactoid symptoms] hard to breathe, whistling sound, difficult to breathe [asthma attack, breathing difficulty] Other side effects not listed here may occur. Check with your doctor/pharmacist if you have any worrisome symptom.  Storage and other information Keep the medicine out of the reach of children. Store it away from direct sunlight, heat and moisture. Use the dissolved medicine within 7 days for storage in the refrigerator, or 20 hours for storage at room temperature. Discard the remainder. Do not store them. ベストロン点眼用０．５％　５ｍｇ（溶解後の液として）