英文药名：LANSAP（Lansoprazole/Amoxicillin Hydrate/Clarithromycin） 中文药名：兰索拉唑~克拉霉素~阿莫西林合剂 生产厂家：武田化学工业有限公司 ランサップ400／ランサップ800 商標名 LANSAP 兰索拉唑 化学構造式 一般名 ランソプラゾール（Lansoprazole）〔JAN〕 化学名 （RS）-2-（{［3-Methyl-4-（2,2,2-trifluoroethoxy）-2-pyridyl］methyl}sulfinyl）benzimidazole 分子式 C16H14F3N3O2S 分子量 369.36 融点 約166℃（分解） 性状 兰索拉唑是白色结晶性粉末，以棕白色带。 N，N-二甲基甲酰胺，以更可溶，容易微溶于甲醇，乙醇（99.5），以微溶，在乙醚中极微溶，并且几乎不溶于水。 阿莫西林水合物 化学構造式 一般名 アモキシシリン水和物（Amoxicillin Hydrate）〔JAN〕 略号 AMPC 化学名 （2S,5R,6R）-6-［（2R）-2-Amino-2-（4-hydroxyphenyl）acetylamino］-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo［3.2.0］heptane-2-carboxylic acid trihydrate 分子式 C16H19N3O5S・3H2O 分子量 419.45 融点 約195℃（分解） 性状 阿莫西林水合物是白色晶体或结晶性粉末，以淡黄白色。微溶于水或甲醇，乙醇（95）非常微溶。 克拉霉素 化学構造式 一般名 クラリスロマイシン（Clarithromycin）〔JAN〕 略号 CAM 化学名 （2R,3S,4S,5R,6R,8R,10R,11R,12S,13R）-5-（3,4,6-Trideoxy-3-dimethylamino-β-D-xylo-hexopyranosyloxy）-3-（2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyloxy）-11,12-dihydroxy-6-methoxy-2,4,6,8,10,12-hexamethyl-9-oxopentadecan-13-olide 分子式 C38H69NO13 分子量 747.95 融点 220～227℃ 性状 克拉霉素是一种白色结晶粉末，味微苦。微溶于丙酮或氯仿，甲醇，乙醇（95）或在乙醚中微溶，并且几乎不溶于水。 适应病症 <Adaptive species> 幽门螺杆菌的阿莫西林，克拉霉素的敏感性 <Indications> 内镜治疗胃溃疡，十二指肠溃疡，胃MALT淋巴瘤，特发性血小板减少性紫癜和早期胃癌胃镜检查后幽门螺旋杆菌感染，幽门螺杆菌感染性胃炎 相关使用说明的效果或疗效 幽门螺杆菌根除治疗 1 高级阶段胃MALT淋巴瘤有效性尚未确立。 2 特发性血小板减少性紫癜，提供必要的指导方针等，进行根除治疗的情况下，唯一的幽门螺旋杆菌根除治疗被认为是适当的。 内镜治疗后内镜胃以外 3 早期胃癌，疗效预防胃癌的幽门螺旋杆菌根除治疗尚未建立。 使用时； 4 *幽门螺杆菌感染性胃炎，以确保这是一个幽门螺杆菌感染性胃炎胃镜和幽门螺杆菌阳性。 用法与用量 通常情况下，一天两次，7天，同时口服一次200毫克（效价） ，克拉霉素，一次750mg的1次30毫克（效价）三药，如阿莫西林水合物兰索拉唑为成人。 克拉霉素可适当增加，根据需要。但是，最多两次（效力）或400mg每天一次。 药效药理 1 抗菌作用 （1）克拉霉素和阿莫西林水合物显示抗菌作用，杀灭幽门螺旋杆菌。 （2）克拉霉素的抗菌受pH的影响，衰减比中性至酸性。另一方面， pH值的影响是小的相比，克拉霉素阿莫西林水合物的。 （3）与阿莫西林和克拉霉素水合物组合的抗菌活性，观察到加性效应或协同作用，拮抗作用尚未观察到任何应变。 此外，兰索拉唑的联合给药和胃组织的增加，口服给药后浓度克拉霉素，阿莫西林水合物（大鼠）观察到。 2 作用机理 阿莫西林水合物，并且还具有通过抑制在细菌细胞壁的合成效果，克拉霉素的细菌的70S核糖体的50S亚基结合，抑制蛋白质的合成，表现出的效果。 结合的SH基团的胃粘膜壁细胞的H + ，K + - ATP酶活性，抑制酶活性，兰索拉唑增加胃内pH值的酸分泌抑制。 据认为通过提高胃内pH ，阿莫西林和克拉霉素的抗菌活性兰索拉唑水合物的作用是增加在三个药物疗法与阿莫西林和克拉霉素水合物。 包装规格 PTP：7片（1片×7），35张（1张×7×5） 制造厂商 武田化学工业有限公司 注：以上部份资料仅供参考，使用时请仔细阅读[附件]：http://www.info.pmda.go.jp/go/pack/6199100X1025_1_25/ LANSAP（Lansoprazole/Amoxicillin Hydrate/Clarithromycin） LANSAP 400（ランサップ400） Brand name : LANSAP 400 　Active ingredient: 1. Takepron capsules 30: Lansoprazole 2. Clarith tab. 200: Clarithromycin 3. AMOLIN CAPSULES 250: Amoxicillin hydrate Dosage form: 1. Takepron capsules 30: capsules with light orange cap and light yellow body, major diameter 15.8 mm, minor diameter 5.8 mm; 2. Clarith tab. 200: white tablets, φ8.6 mm, thickness 5.4 mm; 3. AMOLIN CAPSULES 250: capsules with white cap and white body, major diameter 18.8 mm, minor diameter 6.3 mm, thickness 5.4 mm Print on wrapping: (Face) ランサップ400　1日分（朝　夕）, (Back) ランサップ400の服用方法(Instructions on how to take LANSAP 400) LANSAP 800（ランサップ800） Brand name : LANSAP 800 Active ingredient: 1. Takepron capsules 30: Lansoprazole 2. Clarith tab. 200: Clarithromycin 3. AMOLIN CAPSULES 250: Amoxicillin hydrate Dosage form: 1. Takepron capsules 30: capsules with light orange cap and light yellow body, major diameter 15.8 mm, minor diameter 5.8 mm; 2. Clarith tab. 200: white tablets, φ8.6 mm, thickness 5.4 mm; 3. AMOLIN CAPSULES 250: capsules with white cap and white body, major diameter 18.8 mm, minor diameter 6.3 mm, thickness 5.4 mm Print on wrapping: (Face) ランサップ800　1日分（朝　夕）, (Back) ランサップ800の服用方法(Instructions on how to take LANSAP 800) Effects of this medicine Takepron capsules 30 suppresses gastric acid secretion by inhibiting proton pump in the gastric mucosa, thereby enhancing the antibacterial effects of the antibiotics (Clarith tab. 200 and AMOLIN CAPSULES 250) which exert antibacterial actions against Helicobacter pylori. Usually, used for control of Helicobacter pylori infection of the stomach in gastric ulcer, duodenal ulcer, gastric MALT lymphoma, or idiopathic thrombocytopenic purpura, or after endoscopic therapy for early-stage gastric carcinoma. Before using this medicine, be sure to tell your doctor and pharmacist •If you ever experienced any allergic reaction (itch, rash etc.) to any medicine. If you have infectious mononucleosis, renal disorder, cardiac disease, or liver disorder. If you or your parent(s) or sibling(s) is predisposed to allergic reactions, such as bronchial asthma and rash. If you are incapable of ingesting an adequate amount of diet. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •General dosage regimen: for adults, take 1 capsule of Takepron capsules 30 (30 mg of lansoprazole), 1 tablet of Clarith tab. 200 (200 mg [potency] of clarithromycin) and 3 capsules of AMOLIN CAPSULES 250 (750 mg [potency] of amoxicillin hydrate) at a time, twice a day for 7 days. The dosage of Clarith tab. 200 may be increased as required, up to a maximum of 2 tablets (400 mg [potency]) at a time, twice a day. This medicine is supplied in blister packs, each containing one morning and one evening (good for 1 day) doses (each dose: 1 capsule of Takepron capsules 30, 2 tablets of Clarith tab. 200 and 3 capsules of AMOLIN CAPSULES 250). Strictly follow the instructions of your doctor/pharmacist. •If you miss a dose, take the missed dose as soon as possible. If there is less than 5 hours to the next dose, skip the missed dose and take the next dose at your regular time. DO NOT take double doses to make up for the missed dose. •If you took too much of the medicine (more than ordered), check with your doctor/pharmacist. •Do not stop taking the medicine without the instructions of your doctor. Precautions while taking this medicine • Possible adverse reactions to this medicine After your taking the medicine, gastrointestinal symptoms such as soft stool and diarrhea, taste abnormality, etc. may occur. If any of them occurs, follow the advice given below according to symptoms. In case of soft stool, slight diarrhea, or taste abnormality: Do not adjust or reduce the amount and/or frequency of dose at your discretion but continue following your regular dosing schedule until the last dose (i.e., for 7 days). If the symptoms get worse during continued medication, check with your doctor/pharmacist. In case of diarrhea accompanied with fever and abdominal pain or diarrhea containing mucus or blood: In such instance, stop taking the medicine at once and contact your doctor/pharmacist. Common side effects reported besides the above are as follows. If any of them occurs, check with your doctor/pharmacist: enlarged feeling of abdomen, anemia, rash, itching, glossitis, headache, dizziness, constipation, dry mouth, sleepiness, fever, gynecomastia, nausea, vomiting, loss of appetite, discomfort in the stomach, abdominal pain, hallucination, disorientation (inability to be cognizant of time, location or name), disturbance of consciousness, deliria, mania, ear ringing, decreased hearing acuity, smell abnormality, oral erosion, tooth discoloration, tremor, numbness, palpitation, etc. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •ill feeling, sweating, breathlessness, rash, facial swelling, convulsion [shock, anaphylactic reaction] •dullness, fever, shortness of breath, nasal bleeding/subcutaneous hemorrhage, red-brown urine [pancytopenia, agarnulocytosis, granulocytopenia, hemolytic anemia, decreased platelet count, anemia] •yellowing of the skin or whites of the eyes, dullness, loss of appetite [liver dysfunction, jaundice, liver failure] •fever, general malaise, eruptions on/reddening of the skin and eyes and eruptions/reddening in the mouth [toxic epidermal necrolysis, mucocutaneous-ocular syndrome] •fever, dry cough, breathlessness [PIE syndrome, interstitial pneumonia] •decreased urination output, swelling of face and hands/feet, fever [acute renal failure, serious renal disorder] •abdominal pain, frequent diarrhea, blood in stool [serious colitis] •chest pain, palpitation, chest discomfort [QT prolongation, ventricular tachycardia] •lassitude, muscle pain, brown urine [rhabdomyolysis] •convulsion [convulsion] •purpura [allergic purpura] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store away from direct sunlight, heat and humidity. •Discard the remainder. Do not store them.