Generic Name and Formulations:
Regular insulin (human, recombinant) 100Units/mL; inj.
Company:
Lilly, Eli and Company
Indications for HUMULIN R U-100:
Diabetes.
Adults and Children's Dose:
SC, IV, or IM injection. SC: onset approx 30 minutes, peak 2–4 hrs, duration 6–8 hrs.
See Also:
HUMULIN 70/30
HUMULIN N
HUMULIN R U-500
Warnings/Precautions:
Instruct patients on diet, exercise, blood or urine testing, proper administration of insulin, change in species of origin, type or purity of insulin, and management of hypoglycemia. Dosage increase may be required during infection, illness, stress, trauma, and pregnancy. Dosage decrease may be needed with renal or hepatic dysfunction.
Interactions:
Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, pramlintide, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by corticosteroids, isoniazid, niacin, danazol, diuretics, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, atypical antipsychotics. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. Onset may be delayed if regular insulin is mixed with zinc insulin. Regular and NPH insulins may be mixed and used immediately or stored for future use.
Adverse Reactions:
Hypoglycemia, hypokalemia, local or systemic allergy, lipodystrophy, edema.
How Supplied:
Vials 70/30, N, R (U-100)—10mL; R (U-500)—20mL; Prefilled disposable Pen (70/30, N)—5x3mL
Humulin(人胰岛素)
作用
本药是由DNA遗传基因重组制造的，由非致病的大肠杆菌加入人体胰岛素基因，而逐渐转化而形成，和人体分泌的胰岛素结构完全相同，不含动物杂质，有常规人胰岛素，还有中效胰岛素，低精蛋白锌胰岛素，剂量根据病情而定。 适用于对饮食控制及口服药无效的糖尿病患者，特别是有些人对动物胰岛素过敏，以及对动物胰岛素耐药，有脂质萎缩及脆性糖尿病患者。
副作用
偶见过敏反应。胰岛素耐药、及轻度脂质性营养不良。
剂量
备注
普通人胰岛素可供静脉使用。中效胰岛素和低精蛋白胰岛素只皮下注射，在上臂、大腿、臀部及腰部皮下注射，注射部位需轮换交替，同样的注射部位每月不能重复。