ATROPINE SULFATE（硫酸阿托品[ATROPINE SULFATE]）注射，静脉内，肌内，皮下或气管内使用 最初美国批准：1960年 作用机理 阿托品是一种抗毒蕈碱剂，因为它拮抗乙酰胆碱和其他胆碱酯的毒蕈碱样的动作。 阿托品抑制乙酰胆碱对节后胆碱能神经支配结构的毒蕈碱行动，并在平滑肌其中内源性乙酰胆碱的回应，但不作为支配。与其它抗毒蕈碱剂，阿托品的主要作用是竞争性或克服的拮抗作用可通过在效应器官的受体部位增加乙酰胆碱的浓度（E.G。，通过使用抑制乙酰胆碱的酶破坏抗胆碱酯酶剂）来克服。阿托品拮抗的受体是外围结构确实受到刺激或毒蕈碱（即外分泌腺流畅和心肌）抑制。应对节后胆碱能神经刺激，可能会被阿托品抑制，但这个比来注射（外源性）胆碱酯发生反应不太容易。 适应症和用法 阿托品是指示对重度或威胁生命的毒蕈碱作用暂时封锁毒蕈碱性拮抗剂。 用法用量 ·对于静脉内给药，但因此可通过皮下，肌内或通过气管内管来给药。 滴定gem到心脏率，PR间期，血压和症状。 成人用量 - Antisialagogue或antivagal效果：0.5毫克的初始单剂量为1毫克。 - 解毒剂有机磷或毒蕈碱蘑菇中毒：为2mg最初的单一剂量为3mg，反复每次20-30分钟。 - 给bradyasystolic心脏骤停：1毫克的剂量，重复每隔3-5分钟，如果心跳停止存在。 患者冠心病：总剂量shoulderstand不超过0时03毫克/公斤，以0点04毫克/公斤。 剂型和规格 0.05毫克/毫升注射Ansyr?塑料注射器 0.1毫克/毫升注射Ansyr?塑料注射器 禁忌症 无。 警告和注意事项 心动过速 青光眼 幽门梗阻 恶化尿潴留 粘支气管插头 不良反应 大部分的不良反应都直接关系到阿托品的抗胆碱作用。口腔，视力模糊，畏光和心动过速干，治疗剂量长期服用通常发生。 药物相互作用 美西律：减少美西律的吸收率。 完整资料附件： https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=AD8916E7-206E-409E-2582-30D072845DD4 ATROPINE SULFATE INJECTION, USP Currently, as of 2013, the use of Atropine as a pre-medication to prevent reflex bradycardia – which occurs when the hypopharynx of a child or infant is stimulated by the laryngoscope – is not universal.  There is conflicting evidence on the universal use of  Atropine for pre-medicating Rapid Sequence Intubation (RSI) or Rapid Sequence Induction.  The American College of Emergency Physicians used to recommend atropine 0.01mg/kg, minimum 0.1mg and max 0.4mg prior to RSI for: ■infants less than 1 year of age ■any child less than 8 years of age receiving succinylcholine ■anyone receiving 2 doses of succinylcholine This recommendation is no longer universal.  However, there is some evidence to support the use of atropine in certain pediatric critical populations, and should be considered for relatively sick infants whose cardiac output could potentially be compromised with reflex bradycardia.  Remember that for children and particularly infants, blood pressure & cardiac output can only be increased by increasing heart rate, as stroke volume (SV) and systemic vascular resistance (SVR) cannot increase as readily as in an adult.  You can always give atropine after intubation if needed. perspective, dosing atropine requires either the 0.4mg/mL vial (green or red bottle) or the CodeCart 0.1mg/mL (purple box).  It is very difficult to draw up less than 0.1mg atropine, so the recommendations for pre-treatment with atropine is 0.1mg minimum, no matter what weight.  For the 0.4mg/mL bottle, use the 1-mL insulin or PPD syringe.  For the 0.1mg/mL, you can use a 5-mL syringe.  Please note that the dose of 0.01mg/kg min 0.1mg & max 0.4mg is different than the adult code doses of 0.5mg and 1mg for ACLS. --------------------------------------------------------- 注：以下是美国（厂家：Hospira公司）产品，不同规格和不同价格，采购以在线咨询为准。 --------------------------------------------------------- ATROPINE 0.1MG/ML 10ML SYR 10/PAC  ATROPINE SULFATE     00409-1630-10 ATROPINE 0.1MG/ML 10ML W/NDL SYR 10/PAC  ATROPINE SULFATE     00409-4911-34 ATROPINE 0.1MG/ML 5ML SYR 10/PAC  ATROPINE SULFATE     00409-4910-34  ATROPINE 0.4MG/ML 1ML SDV PF 25/PAC  ATROPINE SULFATE     00517-0401-25   ATROPINE 0.4MG/ML 20ML MDV 10/PAC  ATROPINE SULFATE     00641-6006-10 ATROPINE 1MG/ML 1ML SDV PF 25/PAC  ATROPINE SULFATE     00517-1010-25  HOMATROPINE EYE DROPS 5% 5ML  HOMATROPINE HBR     54799-0431-05