英文药名：LIPITOR(atorvastatin calcium Tablets) 中文药名：阿托伐他汀钙片 生产厂家：辉瑞制药 药品介绍 Atorvastatin是一种HMG-CoA reductase抑制剂，是一种较强的降胆固醇药物，并阻断胆固醇的产生新型药品 美国FDA已批准其降血脂药阿托伐他汀钙（atorvastatin calcium，商标名：立普妥，Lipitor）用于在无证据证明心脏疾病但有其它风险因素的2型糖尿病患者中降低中风和心脏病发作风险。此次本品还获准用于在无证据证明心脏疾病但有除糖尿病之外其它多种风险因素的患者中，降低中风的风险。通常，心脏疾病的风险因素包括高血脂、高血压、家族史、年龄在55岁以上、吸烟、糖尿病和肥胖等。 适应证 本品用于杂合子家族性或非家族原发性高胆固醇血症；纯合子高胆固醇血症；混合型高脂血症。 ----------------------------------------------------- 注：以下产品美国上市包装，不同规格和不同价格,采购以咨询为准！ ------------------------------------------------------ LIPITOR TAB 40MG 90  ATORVASTATIN CALCIUM     00071-0157-23  LIPITOR TAB 10MG DS 5000  ATORVASTATIN CALCIUM     00071-0155-34  LIPITOR TAB 80MG 90  ATORVASTATIN CALCIUM     00071-0158-23  LIPITOR TAB 20MG UD 10X10  ATORVASTATIN CALCIUM     00071-0156-40 LIPITOR TAB 40MG UD 10X10  ATORVASTATIN CALCIUM     00071-0157-40 LIPITOR TAB 40MG DS 2500  ATORVASTATIN CALCIUM     00071-0157-88  LIPITOR TAB 80MG DS 2500  ATORVASTATIN CALCIUM     00071-0158-88  LIPITOR TAB 20MG DS 5000  ATORVASTATIN CALCIUM     00071-0156-94  LIPITOR TAB 40MG 500  ATORVASTATIN CALCIUM     00071-0157-73  LIPITOR TAB 80MG 500=  ATORVASTATIN CALCIUM     00071-0158-73  LIPITOR TAB 20MG 90  ATORVASTATIN CALCIUM     00071-0156-23  LIPITOR TAB 10MG 90  ATORVASTATIN CALCIUM     00071-0155-23  LIPITOR TAB 10MG UD 10X10  ATORVASTATIN CALCIUM     00071-0155-40 Lipitor (atorvastatin calcium) General Information Lipitor (atorvastatin calcium) is a synthetic lipid-lowering agent. It is an inhibitor of the enzyme HMG-CoA reductase. By blocking or inhibiting the action of HMG-CoA reductase, a link is broken in the chain of reactions that produces cholesterol. When less cholesterol is produced, the liver takes up more cholesterol from the bloodstream, which results in lower levels of cholesterol circulating in the blood. Lipitor is specifically indicated for the prevention of cardiovascular disease, including myocardial infarction and stroke, and for primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia. Lipitor is supplied as a tablet for oral administration. The recommended initial dose of Lipitor is 10 or 20 mg once daily. Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg once daily. The dosage range of Lipitor is 10 to 80 mg once daily, based on patient characteristics such as goal of therapy and response. LIPITOR Rx Generic Name and Formulations: Atorvastatin (as calcium) 10mg, 20mg, 40mg, 80mg; tabs. Company: Pfizer Inc. Indications for LIPITOR: Adjunct to diet in primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Types IIa and IIb) to reduce total-C, LDL-C, apo B and TG, and to increase HDL-C. Adjunct to diet in treating elevated serum TG (Type IV). Treatment of primary dysbetalipoproteinemia (Type III) not adequately responsive to diet. Adjunct to other lipid-lowering treatments (or when these are unavailable), in homozygous familial hypercholesterolemia to reduce total-C and LDL-C. Adjunct to diet to reduce total-C, LDL-C and apo B in patients 10–17 years of age (≥1 year post-menarche) with heterozygous familial hypercholesterolemia if LDL-C remains ≥190mg/dL, or if LDL-C remains ≥160mg/dL with either family history of premature cardiovascular disease (CVD) or if patient has at least 2 other CVD risk factors. To reduce risk of MI, stroke, and risk of revascularization procedures in adults at risk (see full labeling). To reduce risk of MI and stroke in patients with type 2 diabetes and at risk (see full labeling). To reduce the risk of non-fatal MI, fatal and non-fatal stroke, revascularization, hospitalization for CHF, and angina in patients with clinically evident coronary heart disease. Limitations of use: not studied where major abnormality is elevation of chylomicrons (Fredrickson Types I and V). Adult Dose for LIPITOR: ≥17yrs: Heterozygous and Types IIa and IIb: initially 10 or 20mg once daily; if more than a 45% reduction in LDL-C is needed, may start at 40mg once daily; range 10–80mg once daily. Homozygous: 10–80mg daily. Concomitant clarithromycin, itraconazole, saquinavir + ritonavir, darunavir + ritonavir, fosamprenavir or fosamprenavir + ritonavir: max 20mg/day. Concomitant nelfinavir or boceprevir: max 40mg/day. Children's Dose for LIPITOR: Heterozygous: <10yrs: not recommended. 10–17yrs: initially 10mg/day, may increase to 20mg/day after at least 4 weeks. Homozygous: 80mg/day has been used; see literature. Pharmacological Class: HMG-CoA reductase inhibitor. Contraindications: Active liver disease. Unexplained persistent elevated serum transaminases. Pregnancy (Cat.X). Nursing mothers. Warnings/Precautions: Discontinue if myopathy, elevated CPK levels occur; suspend if a predisposition to development of renal failure secondary to rhabdomyolysis develops. Monitor liver function before starting therapy and repeat as clinically indicated. History of liver disease. Substantial alcohol ingestion. Hemorrhagic stroke. Elderly. Interactions: See Adult dose. Avoid with concomitant cyclosporine, gemfibrozil, tipranavir + ritonavir, telaprevir. Potentiated by strong CYP3A4 inhibitors, grapefruit juice (>1.2L/day). Caution with lopinavir + ritonavir, other fibrates, niacin (≥1g/day), colchicine; consider dose reduction of atorvastatin. May increase serum levels of digoxin, oral contraceptives (norethindrone, ethinyl estradiol); monitor digoxin. Caution with drugs that decrease levels or activity of steroid hormones (eg, ketoconazole, spironolactone, cimetidine). Adverse Reactions: GI upset, headache, myalgia, arthralgia, rash, elevated serum transaminases, myopathy, rhabdomyolysis with renal dysfunction; increased HbA1c and fasting serum glucose, cognitive impairment; rare: immune-mediated necrotizing myopathy. How Supplied: Tabs 10mg, 20mg—90, 5000; 40mg, 80mg—90, 500, 2500 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c6e131fe-e7df-4876-83f7-9156fc4e8228