英文药名：Losarhyd Combination Tablets LD（Losartan Potassium/Hydrochlorothiazide） 中文药名： 氯沙坦钾/氢氯噻嗪配合錠LD 日文药名：ロサルヒド配合錠LD「FFP」 生产厂家：富士制药 药品介绍 治疗类别名称 可持续发展ARB/利尿剂组合 批准上市时间：2014年 商標名 Losarhyd Combination Tablets LD「FFP」 一般名 ロサルタンカリウム（Losartan Potassium） 化学名 Monopotassium 5-｛［4’-（2-butyl-4-chloro-5-hydroxymethyl-1H-imidazol-1-yl）methyl］biphenyl-2-yl｝-1H-tetrazol-1-ide 分子式 C22H22CIKN6O 分子量 461.00 構造式 性　状 白色の結晶性の粉末である。 水に極めて溶けやすく、メタノール又はエタノール（99.5）に溶けやすい。 一般名 ヒドロクロロチアジド（Hydrochlorothiazide） 化学名 6-Chloro-3，4-dihydro-2H-1，2，4-benzothiadiazine-7-sulfonamide 1，1-dioxide 分子式 C7H8CIN3O4S2 分子量 297.74 構造式 性　状 白色结晶或结晶性粉末，无臭，味微苦。 它是易溶于丙酮，稍少溶于乙腈，极微溶于水或乙醇（95），并在乙醚中几乎不溶。我溶于氢氧化钠试剂。 熔点：约267℃（分解） 操作注意事项 稳定性测试 加速测试使用的是结果的最终包装产品（40℃，相对湿度75％，6个月），Rosaruhido组合片LD“FFP”据推测，根据市场分布正常稳定3年 有效成分：氯沙坦钾  Losartan Potassium，氢氯噻嗪 Hydrochlorothiazide 适应证 高血压、心力衰竭。 禁忌证 对该药过敏者。 注意事项 1.血容量不足者可出现症状性低血压，故用药前应纠正血容量不足的情况； 2.肝功能损害者建议减少药物的剂量； 3.双侧肾动脉狭窄或单侧肾动脉狭窄者服药后可能出现可逆性肌酐、尿素氮增高，应定期监测； 4.与保钾利尿剂、补钾剂或含钾药物服用时，会使血钾升高，应定期监测血钾水平。 不良反应 头痛、直立性低血压。其他的不良反应有：过敏、血管神经性水肿、肝功能异常、胃肠道反应及肌痛等。 用法用量 起始和维持剂量为50mg，每天1次，治疗3～6周达最大降压效应。部分患者每天100mg，可产生进一步的降压作用。 药物相应作用 未发现有临床意义的药物相互作用，包括氢氯噻嗪、地高辛、华法林、西咪替丁等；与保钾利尿剂、补钾剂合用，会使血钾升高。 包装规格 （PTP包装）　100錠（10錠×10）、140錠（14錠×10） 生产厂商 富士制药社 Brand name : Losarhyd Combination Tablets LD "FFP" 　Active ingredient: Losartan potassium  Hydrochlorothiazide 　Dosage form: white tablet, diameter: 8.9 mm, thickness: 4.1 mm 　Print on wrapping: ロサルヒド配合錠LD「FFP」,ロサルヒド,LD,n855,NICHI-IKO,Losarhyd LD Effects of this medicine This medicine has angiotensin II receptor antagonistic activity and promotional action of sodium excretion to decrease blood pressure. It is usually used to treat hypertension. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have liver dysfunction, anuria, acute renal failure or diabetes mellitus. If you are patient whose amount of sodium and potassium in the fluid has been definitely decreased. If you are on dialysis. •If you are pregnant, possibly pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •In general, for adults, take 1 tablet at a time, once a day. Strictly follow the instructions. •If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine •This medicine may cause dizziness/light headedness due to its hypotensive action. Be aware of operating in potentially hazardous activities such as driving a car and working at heights. •Intake of alcohol may enhance the effect of this medicine. Refrain from drinking alcohol while taking this medicine. Possible adverse reactions to this medicine The most commonly reported adverse reactions include dizziness, frequent urination and headache. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •discomfort, oral discomfort, sweating[anaphylaxis] •swelling of face/lip/throat/tongue[angioedema] •loss of appetite, general malaise, nausea/vomiting[acute hepatitis, fulminant hepatitis] •decreased urine output, edema of limbs/face, general malaise[acute renal failure] •coldness, vomiting, loss of consciousness[shock, faint, loss of consciousness] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store away from direct sunlight, heat and moisture. •Discard the remainder. Do not store them. http://www.info.pmda.go.jp/go/pack/2149110F1090_1_02/2149110F1090_1_02?view=body#105