英文药名：LANIRAPID（Metildigoxin Tablet） 中文药名：甲地高辛片 生产厂家：中外制药 ラニラピッド錠0.05mg／ラニラピッド錠0.1mg 薬效分类名 强心配糖体制剤 商標名 LANIRAPID 一般名 メチルジゴキシン（Metildigoxin）（JAN） 化学名 3β-[2,6-Dideoxy-4-O-methyl-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyloxy]-12β,14-dihydroxy-5β-card-20(22)-enolide―acetone(2/1) 構造式 分子式 C42H66O14・1/2C3H6O 分子量 824.00 性　状 本产品是白色结晶性粉末，以淡黄白色。 N，N-二甲基甲酰胺，并易溶于吡啶或乙酸（100），微溶于氯仿，稍少溶于甲醇，乙醇（95）或微溶于丙酮，和极微溶于水，在乙醚中几乎不溶没有。 适应证 适用于急性心力衰竭和慢性心力衰竭。 用法用量 口服每次0.2mg，每天2次，2～3天后服维持量，每次0.1mg，每天1～2次。 禁忌证 参见：地高辛 注意事项 对肾功能损害患者半衰期明显延长，故肾衰患者应适当减少用药剂量。其他注意事项同地高辛。 包装规格 0.05mg*100片（PTP）1,000片（PTP） 0.1mg*100片 （PTP）1,000片（PTP，瓶） 生产厂商 中外制药有限公司 注：使用以原处方为准：http://www.kegg.jp/medicus-bin/japic_med?japic_code=00047945 LANIRAPID Tablet（Metildigoxin） LANIRAPID Tablet 0.05mg（ラニラピッド錠0.05mg）  Brand name : LANIRAPID Tablet 0.05mg 　Active ingredient: Metildigoxin 　Dosage form: white tablet (major axis: 8.0mm × minor axis: 4.5mm, thickness: 2.2mm) 　Print on wrapping: ラニラピッド0.05mg,Lanirapid0.05mg LANIRAPID Tablet 0.1mg（ラニラピッド錠0.1mg） Brand name : LANIRAPID Tablet 0.1mg 　Active ingredient: Metildigoxin 　Dosage form: white tablet (φ: 7.0mm, thickness: 2.4mm) 　Print on wrapping: ラニラピッド0.1mg, Lanirapid0.1mg Effects of this medicine This medicine works on heart directly to strengthen myocardial contractile force and to adjust excessively fast pulse. It is usually used to treat congestive cardiac failure, fast pulse caused by atrial fibrillation and atrial flutter, and paroxysmal supraventricular tachycardia. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reaction (itch, rash etc.) to any medicines. If you are a patient with atrioventricular block, sinoatrial block, digitalism, obstructive myocardiopathy, acute myocardial infarction, premature ventricular contraction, pericarditis, cor pulmonale, WPW syndrome, electrolyte abnormality (hypokalemia, hypercalcemia, hypomagnesemia, etc.), renal disease, hypothyroidism, or hyperthyroidism. If you are a patient on hemodialysis. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •In the case of rapid saturation method [saturation dosage: 6-18 tablets (0.6-1.8mg of the active ingredient)], take 2-3 tablets (0.2-0.3mg of the active ingredient) at the first and after that keep taking 2 tablets (0.2mg of the active ingredient) at a time, 3 times a day until you get enough effectiveness from it. In the case of maintenance treatment, take 1-2 tablet(s) (0.1-0.2mg of the active ingredient) a day. Strictly follow the instructions in any case. •The effect dose is very close to the toxic dose. The dosage should be adjusted according to your blood constitutes. Be sure to visit your doctor to check the blood constitutes periodically. •If you missed a dose, skip the missed dose and continue your regular dosing schedule. If you have any questions, ask your doctor or pharmacist. However, you should never take two doses at one time. •If you accidentally took more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine •Avoid taking hypericum perforatum (Saint John's wort)-containing food, since it affects this medicine. Possible adverse reactions to this medicine The most commonly reported adverse reactions include nausea/vomiting, loss of appetite, arrhythmia, bradycardia, diarrhea, urticaria, purpura, edema and rash. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •very slow pulse, fast pulse, irregular heartbeat, disturbed pulse, shortness of breath, sudden loss of consciousness, chest constrictive feeling, chest pain [digitalism (severe marked bradycardia, bigeminy, multifocal premature ventricular contraction, paroxysmal atrial tachycardia, atrioventricular block, ventricular tachycardia, arrhythmia such as ventricular fibrillation)] •severe abdominal pain, bloody stool, fever, nausea, vomiting [non-occlusive mesenteric ischemia] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store at room temperature (1-30℃), away from direct sunlight and moisture. •Discard the remainder. Do not store them. Ask the pharmacist or healthcare facility how to discard them.