英文药名：DESMOPRESSIN Spray（Desmopressin Acetate Hydrate）

中文药名：醋酸去氨加压素喷雾剂

生产厂家：协和发酵麒麟
类别名称
夜尿症用剤
欧文商標名
DESMOPRESSIN Spray
一般名
デスモプレシン酢酸塩水和物　Desmopressin Acetate Hydrate
化学名
1-Deamino-8-D-arginine-vasopressin acetate trihydrate
略名
DDAVP
分子式
C46H64N14O12S2・C2H4O2・3H2O＝1183.31
構造式

性状
它是一种白色粉末。
溶解性
水，易溶于甲醇或乙酸（100），和微溶于乙醇（99.5）。
适应症
与降低尿渗透压或尿比重相关联的以下疾病
夜尿
用法用量
在20μg的通常开始于睡前鼻内从10微克（1喷涂）为醋酸去氨加压素水合物每日一次睡前服用，如果效果不够的，因为醋酸去氨加压素水合物每日一次提高到（2喷洒）。
应当指出的是，最高剂量一天将与20μg的（2喷洒）如去氨加压素乙酸水合物。
（鼻内接种）
请参照“关于应用。
包装规格
500μg*1瓶

125μg*1瓶

生产商：协和发酵麒麟有限公司
DESMOPRESSIN Spray（Desmopressin acetate hydrate）
DESMOPRESSIN・Spray 10 Kyowa（デスモプレシン・スプレー10協和）
Brand name : DESMOPRESSIN・Spray 10 Kyowa
　Active ingredient: Desmopressin acetate hydrate
　Dosage form: nasal spray
　Print on wrapping: (labeling) KH408 デスモプレシン・スプレー10協和
DESMOPRESSIN・Spray 2.5 Kyowa（デスモプレシン・スプレー2.5協和）
Brand name : DESMOPRESSIN・Spray 2.5 Kyowa
　Active ingredient: Desmopressin acetate hydrate
　Dosage form: nasal spray
　Print on wrapping: (labeling) KH407 デスモプレシン・スプレー2.5協和
Effects of this medicine
This medicine has the same action as "vasopressin", an antidiuretic hormone to control urine volume, secreted from pituitary gland in the brain. It is a nasal spray which promotes reabsorption of water in renal tubule of the kidney to concentrate urine and consequently prevents excessive urination.
It is usually used in the treatment of central diabetes insipidus.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have: hypertension, coronary artery thrombosis, angina pectoris, anterior pituitary dysfunction or nasal disease (including its history).
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for children, use 1 to 2 sprays (2.5-5 mcg of the active ingredient); for adults, use 2 to 4 sprays (5-10 mcg) into nostril at a time, once to twice daily. The dosage may be adjusted according to the amount of water ingestion, urinary volume, specific gravity of urine and urine osmolality. Strictly follow the instructions.
•When the bottle of the medicine is used for the first time or it has not been used for more than a week, press the pump several times (approx. 4 times) and make sure that the medicine is sprayed in the form of a mist. Blow your nose before using to stabilize absorption of the medicine. In using, make sure that the end of the tube inside the bottle is placed in the liquid and spray at one push. According to the instruction in another sheet supplied with the medicine (the instruction is written only in Japanese), try to use the medicine faster and more accurately.
•If you missed a dose, use a dose as soon as possible. If you instructed to use the medicine twice daily, wait approx. 6 hours to use the next dose. You should never use two doses at one time.
•If you accidentally used more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop using this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Be aware of the amount of water ingestion to avoid excessive intake.
•Severe dehydration may occur in infants who cannot take water on their own. Make sure to let them drink a proper amount of water on a daily basis.
•If you have rhinitis or injury in nose, and it is difficult to use the medicine, consult with your doctor or pharmacist immediately.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include headache, loss of appetite, nausea, vomiting, facial edema, abdominal pain, nasal bleeding, fever, insomnia, somnolence and nasal discomfort. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•malaise, headache, nausea [water intoxication]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of the reach of children. Avoid freezing and store in a refrigerator, and keep the bottle at a standing position.
•When you carry the medicine with you, put the bottle in a package and keep the bottle at a standing position in a bag (if you put it in your pocket, the medicine may leak out due to warming by your body temperature).
•When you go on a tour and carry the medicine with you, avoid keeping it at a high temperature and keep it at a stable temperature.
•Discard the remainder. Do not store them. Ask the pharmacist how to discard them.
Kyowa Hakko Kirin Co.,LtdExternal
Revised: 7/2011
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
http://meds.qlifepro.com/detail/660470004/ddavp
http://www.kegg.jp/medicus-bin/japic_med?japic_code=00049408