英文药名: Dellegra combination tablets（Fexofenadine Hydrochloride/Pseudoephedrine Hydrochloride） 中文药名: 盐酸非索非那定/盐酸伪麻黄碱配合片 生产厂家: 赛诺菲制药 治疗类别名称 过敏性疾病治疗药物 商标名 Dellegra combination tablets 盐酸非索非那定 一般名 フェキソフェナジン塩酸塩（Fexofenadine Hydrochloride） 化学名 2-（4-｛（1RS）-1-Hydroxy-4-［4-（hydroxydiphenylmethyl）piperidin-1-yl］butyl｝phenyl）-2-methylpropanoic acid monohydrochloride 分子式 C32H39NO4・HCl 分子量 538.12 構造式 性　状 本品是一种白色结晶粉末。 它是在甲醇非常易溶，乙醇（99.5）微溶，微溶于水。 这种产品的甲醇溶液（3→100）示出了没有旋光性。 分配系数 2.0（pH值为7，水？辛醇系统） 盐酸伪麻黄碱 一般名 塩酸プソイドエフェドリン（Pseudoephedrine Hydrochloride） 化学名 （1S, 2S）-2-methylamino-1-phenylpropan-1-ol monohydrochloride 分子式 C10H15NO・HCl 分子量 201.69 構造式 性　状 本产品是一种白色结晶或结晶性粉末。 该产品是水，易溶于甲醇或乙酸（100），乙醇（99.5），以易微溶，并在乙酸酐几乎不溶。 适应病症 过敏性鼻炎 用法用量 成年人，一个成年人，在12岁以上的孩子两片一次，一天两次（非索非那定为为120mg和60毫克盐酸伪麻黄碱盐酸盐），在早晚口服空腹 药效药理 盐酸非索非那 非索非那定盐酸盐是一种具有选择性组胺H1受体的药物具有拮抗作用，进一步炎性细胞因子产生抑制作用，嗜酸性粒细胞迁移抑制作用和化学介质释放抑制作用作为主要动作。 •组胺H1受体拮抗剂 盐酸非索非那定，组胺和拮抗组胺H1受体，抑制离体豚鼠回肠准备和气管标本组胺引起的收缩（10-7〜3×10-6M）。另外，它抑制了在全身给药的豚鼠的组胺诱发气道收缩和皮肤反应。另外，对于非索非那定盐酸肾上腺素，乙酰胆碱，为每个受体以及血清素和速激肽的L-型钙通道的亲和力是不允许的。 •在I型变态反应性疾病模型动物的影响 盐酸非索非那定，豚鼠抗原诱发的过敏性鼻炎，大鼠被动皮肤过敏（PCA）反应，抑制大鼠抗原诱导的全身过敏反应和豚鼠抗原诱导的哮喘即时反应。 •嗜酸性粒细胞，炎性细胞因子和细胞黏附分子的作用。 盐酸非索非那定抑制由上述10-6M人类活动引起的嗜酸性粒细胞鼻腔黏膜上皮细胞培养上清来源的季节性过敏性鼻炎患者的迁移。此外，炎性细胞因子被释放到培养物上清液时从鼻粘膜季节性过敏性鼻炎患者的培养的上皮细胞与激活的人嗜酸性粒细胞的IL-8和GM-CSF，分别10-6M抑制或更多，10 -9 M或更高，它减少了sICAM-1的是一个细胞粘附分子或10-9 M. •化学介质释放的抑制作用 非索非那定盐酸盐抑制从外周血嗜碱性粒细胞和患者外周血白细胞与健康成年人（10-6〜10-5M）的特应性皮炎用抗人IgE抗体的刺激的组胺释放。此外，它在豚鼠抗原诱发速发型哮喘模型减少支气管肺泡灌洗液（BALF）中的白三烯量。 盐酸伪麻黄碱 盐酸伪麻黄碱刺激α受体，收缩鼻黏膜的血管平滑肌，减少血流量，减轻鼻粘膜充血肿胀，显示出强大的鼻塞改善。 包装规格 配合片 30mg/60mg*100片/盒 生产商 日本赛诺菲制药 Dellegra combination tablets（Fexofenadine Hydrochloride/Pseudoephedrine Hydrochloride  ディレグラ配合錠） Brand name : Dellegra combination tablets 　Active ingredient: Fexofenadine hydrochloride/Pseudoephedrine hydrochloride  　Dosage form: pale orange tablet, major axis: 17.5 mm, minor axis: 7.8 mm 　Print on wrapping: ディレグラ配合錠, Dellegra Effects of this medicine Fexofenadine hydrochloride has antagonistic action on H1 receptors and suppressive action on releasing of various chemical mediators. Pseudoephedrine hydrochloride decreases blood flow of nasal mucosa and shows effective improvement on nasal congestion. It improves symptoms of sneezing, runny nose and nasal congestion associated with seasonal allergic rhinitis such as cedar pollinosis, and perennial allergic rhinitis caused by mite and house dust. It is usually used in the treatment of allergic rhinitis. Before using this medicine, be sure to tell your doctor and pharmacist •If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines. If you have: hypertension, coronary artery disease, narrow-angle glaucoma or urinary retention. If you have a history of insomnia, dizziness, weakness, tremor or arrhythmia induced by sympathomimetic drug. •If you are pregnant or breastfeeding. •If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.) Dosing schedule (How to take this medicine) •Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>> •In general, for adults and children aged 12 years and older, take 2 tablets at a time, twice daily, in the morning and evening, on an empty stomach. Strictly follow the instructions. •Never chew or crush the tablet since this medicine contains controlled-release layer. Swallow with water as it is. •Because this controlled-release layer is hard to melt, it may be excreted in the feces as a tablet after active ingredient release. •If you miss a dose, take a dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time. •If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist. •Do not stop taking this medicine unless your doctor instructs you to do so. Precautions while taking this medicine • Possible adverse reactions to this medicine The most commonly reported adverse reactions include headache, rash, fatigue and dry mouth. If any of these symptoms occur, consult with your doctor or pharmacist. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately. •breathing difficulty, blood pressure decreased, loss of consciousness, angioedema, chest pain, flushing  [shock, anaphylaxis] •paroxysmal muscle contraction  [convulsion] •general malaise, loss of appetite, yellowing in skin and white of eyes  [hepatic dysfunction, jaundice] •throat pain, headache, muscle pain, high fever with chilliness and shivering  [agranulocytosis, leucopenia, neutropenia] The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above. Storage conditions and other information •Keep out of the reach of children. Store away from direct sunlight, heat and moisture. •Discard the remainder. Do not store them.