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当前位置:药品说明书与价格首页 >> 心血管系统 >> 新药推荐 >> 西药 >> Nitorol Tablets(硝酸异山梨醇酯口服片/舌下含片)

Nitorol Tablets(硝酸异山梨醇酯口服片/舌下含片)

2016-06-27 01:00:39  作者:新特药房  来源:互联网  浏览次数:40  文字大小:【】【】【
简介: 英文药名:Nitorol Tablets(Isosorbide Dinitrate) 中文药名:硝酸异山梨醇酯片 生产厂家:卫材药品 ニトロール錠5mg 治疗类别名称缺血性心脏疾病的治疗剂商標名 Nitorol一 般 名硝酸イソソルビ ...

英文药名:Nitorol Tablets(Isosorbide Dinitrate)

中文药名:硝酸异山梨醇酯片

生产厂家:卫材药品

ニトロール錠5mg

治疗类别名称
缺血性心脏疾病的治疗剂
商標名
Nitorol
一 般 名
硝酸イソソルビド(Isosorbide Dinitrate)
化学名
1, 4 : 3, 6‐Dianhydro‐D‐glucitol dinitrate
分子式
C6H8N2O8
分子量
236.14
構造式

物理化学的性状
硝酸异山梨醇酯是一种白色结晶或结晶性粉末,或者没有异味,或微有硝酸气味等等。
此产品是N,N-二甲基甲酰胺或非常易溶于丙酮,易溶于氯仿或甲苯,甲醇,乙醇(95)或在乙醚中微溶,并且几乎不溶于水。
该产品将爆炸给或快速震荡热量。
操作注意事项
1.温度,在高湿度下长期保存可晶体到片剂表面沉积。
2.本剂,因为内容在无包装打开状态的减少已观察,是为了避免存储在自动包装机。此外,长期的填料处方应该避免。
3.包装后,要注意如果可能的话在阴凉的地方保存。
适应病症
心绞痛,心肌梗塞等缺血性心脏疾病
用法用量
口服给药
成人;每天一次,每次口服1-2片剂(5-10毫克)。此外,增加或减少取决于患者的年龄和症状。
舌下给药
狭窄的心脏发作,每天一次,每次口服1-2片剂(5-10毫克)是舌下给药。
除了窄心脏发作期间,通常成人舌下给药一次1-2片(5-10毫克作为消心痛)。
此外,增加或减少取决于患者的年龄和症状。
药效药理
1. 前、后预载缓解作用
在麻醉的狗的实验中,该药物是通过静脉系统容量血管的膨胀导致的,减少的静脉回流,肺动脉楔压的降低和左心室舒张末期压力(预负荷的浮雕)。同时,延长外周动脉,导致降低总外周血管阻力(后负荷降低)。这些效应降低心脏肌肉的需氧量。
2. 冠状动脉血管扩张作用
在麻醉狗实验中,这种药是扩展比较厚的冠状动脉(导电容器),与降低冠脉阻力也延长沿侧支循环,虽然在冠状动脉血流量的增加是未成年人,Kyochibu心肌,促使血液流供给的重新分配,以在特定的内膜下的心脏肌肉,已观察到增加心脏肌肉的氧气供给。
3. cGMP产生作用
由氯化钾,加入该药物到小腿,这是收缩的离体冠状动脉,生产的cGMP的按比例增大到冠状动脉的松弛。
包装规格
片剂
5mg:100片(PTP):500粒(瓶)1000片(PTP)
制造厂商
卫材有限公司


Nitorol Tablets(Isosorbide dinitrate)
Nitorol Tablets 5mg(ニトロール錠5mg)
Brand name : Nitorol Tablets 5mg
 Active ingredient: Isosorbide dinitrate
 Dosage form: white tablet, diameter 6.1mm, thickness 2.6mm
 Print on wrapping: (Face) ニトロール5mg, ENR5
(Back) ENR5, Nitorol, 5mg, ニトロール
Effects of this medicine
This medicine dilates the venous and peripheral vascular systems to reduce the work load of the heart and dilates the coronary arteries to increase the oxygen supply to the heart, alleviating oxygen shortage in the heart promptly. It relieves the symptoms such as feeling of tightness in the chest or sharp chest pain due to cardiac ischemia.
It is usually used for treatment of ischemic heart disease such as angina or myocardial infarction.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reaction(itch, rash, etc.) to any medicine.
If you have hypotension, cardiogenic shock, glaucoma, anemia, head trauma, brain hemorrhage, pulmonary hypertension or cardiomyopathy.
If you are taking sildenafil citrate (Viagra, Revatio), vardenafil hydrochloride hydrate (Levitra), tadalafil (Cialis, Zalutia, Adcirca) or riociguat (Adempas).
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•In general, for adults, take 1 to 2 tablets (5 to 10 mg as the active ingredient) at a time, 3 to 4 times a day orally or sublingually, to be adjusted depending on the disease, symptom severity or age. Strictly follow the instructions.
During angina attack: In general, for adults, take 1 to 2 tablets (5 to 10 mg as the active ingredient) at a time sublingually, to be adjusted depending on symptom severity or age. Strictly follow the instructions.
•If you miss a dose, take a dose as soon as possible if you remember that you missed a dose 6 hours or over before the next dose. If it is 6 hours or less before the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•This medicine may cause attention deficit or loss of concentration/reflexes. Avoid operating a motor vehicle or machinery.
•Use caution when consuming alcoholic beverages, since consuming too much alcohol while on this medication may cause headache, dizziness or dizziness on standing up.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, headache and dizziness. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
No pertinent entries.
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep this medicine out of the reach of children and away from direct sunlight, heat or moisture.
•If you have leftover medicines, dispose of them appropriately and do not keep any unused medicine.
Eisai Co., Ltd.External
Revised: 7/2014
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.

责任编辑:admin


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