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当前位置:药品说明书与价格首页 >> 精神心理 >> 精神分裂症 >> 药品推荐 >> VEGETAMIN-A-B Combination Tablets(氯丙嗪/异丙嗪/苯巴比妥组合片)

VEGETAMIN-A-B Combination Tablets(氯丙嗪/异丙嗪/苯巴比妥组合片)

2016-10-01 08:18:50  作者:新特药房  来源:互联网  浏览次数:15  文字大小:【】【】【
简介: 英文药名:VEGETAMIN-A-B Combination Tablets(Chlorpromazine Hydrochloride/Promethazine Hydrochloride/Phenobarbital) 中文药名:盐酸氯丙嗪/盐酸异丙嗪/苯巴比妥A B组合片 生产厂家:盐野义 ...

英文药名:VEGETAMIN-A-B Combination Tablets(Chlorpromazine Hydrochloride/Promethazine Hydrochloride/Phenobarbital)

中文药名:盐酸氯丙嗪/盐酸异丙嗪/苯巴比妥A B组合片

生产厂家:盐野义制药

ベゲタミン-A配合錠/ベゲタミン-B配合錠

治疗类别名称
精神神经用剂
欧文商標名
Vegetamin
1.一般的名称
クロルプロマジン塩酸塩(JAN)[日局]
Chlorpromazine Hydrochloride
化学名:3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropylamine monohydrochloride
分子式:C17H19ClN2S・HCl
分子量:355.33
化学構造式:


 
性状:
在白色的结晶细黄色的粉末,或者没有异味,或者有轻微异味。
非常易溶于水,乙醇(95)或易溶于乙酸(100),微溶于乙酸酐,并在乙醚中几乎不溶。
光逐渐着色。
熔点:194〜198℃
分配系数:134896[1辛醇/水]
2. 一般的名称
プロメタジン塩酸塩(JAN)[日局]
Promethazine Hydrochloride
化学名:(2RS)-N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-ylamine monohydrochloride
分子式:C17H20N2S・HCl
分子量:320.88
化学構造式:

性状:
白色至浅黄色粉末。
非常易溶于水,乙醇(95)或易溶于乙酸(100),微溶于乙酸酐,并在乙醚中几乎不溶。
光逐渐着色。
水溶液(1→25)示出了没有旋光性。
熔点:223左右℃(分解)
分配系数:708[pH7.4,1-辛醇/缓冲]
3. 一般的名称
フェノバルビタール(JAN)[日局]
Phenobarbital
化学名:5-Ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
分子式:C12H12N2O3
分子量:232.24
化学構造式:


 
性状:
它是一种白色晶体或结晶粉末。
N,N-二甲基甲酰胺以非常易溶,乙醇(95)或溶于丙酮,难溶于乙腈,在水中极微溶解。
溶于氢氧化钠TS。
饱和水溶液的pH值是从5.0至6.0。
熔点:175〜179℃
分配系数:
33.9[pH7.4,1-辛醇/缓冲]
药效药理
1. 中枢抑制作用
(1) 盐酸氯丙嗪和苯巴比妥的协同
这两种药物的协同作用的镇静作用进行了测试在小鼠中作为指标翻正反射的丧失。其结果是在所有的不显示各单剂的效果的量,这两种药剂Begetamin-A组合片剂,通过其量为B组合片剂的配合比例,协同作用2至10倍配混了根据它指出。
(2) 盐酸氯丙嗪和盐酸异丙嗪的拮抗作用
这两种试剂的锥体外系症状的拮抗作用,进行了测试如在大鼠指示剂僵住症诱发作用。结果是盐酸氯丙嗪量僵住症诱导,Begetamin-A组合片,按照为B组合片剂的配合比例组合使用盐酸异丙嗪表明拮抗显著抑制。
2. 催眠作用
Begetamin-A组合片剂1/2平板电脑健康成人的显著量男性7例,经整夜多导睡眠到Begetamin-A组合片行政晚上和安慰剂夜的差异进行比较。
在Begetamin-A组合片剂管理的夜晚相比,控制夜间,REM睡眠和睡眠阶段(浅睡)是出场率,金额都几乎没有变化。然而,在睡眠阶段3的增加,呈下降趋势。在SWS,该合并的睡眠阶段(慢波睡眠),但在发生率的变化是降低量增加。
适应病症
精神分裂症,老年性精神病,躁狂症,抑郁症或抑郁症,神经官能症。
用法用量
镇静,通常以每3天成人的口服给药划分到4个片。
催眠,通常在每天睡前成人口服给药1-2片。
此外,增加或减少取决于患者的年龄和症状。
包装规格
A组合片:
瓶500粒 PTP500片(10片×50)
B组合片:瓶500粒PTP500片(10片×50)
制造厂商
盐野义制药有限公司
完整处方资料来源:http://www.info.pmda.go.jp/go/pack/1179100F1032_1_10/
VEGETAMIN-A-B Combination Tablets(Chlorpromazine Hydrochloride/Promethazine Hydrochloride/Phenobarbital)
VEGETAMIN-A Combination Tablets(ベゲタミン-A配合錠)
 
Brand name : VEGETAMIN-A Combination Tablets
 Active ingredient: Chlorpromazine hydrochloride
 Promethazine hydrochloride
 Phenobarbital
 Dosage form: red tablet, diameter: 9.2 mm, thickness: 5.2 mm
 Print on wrapping: (Face) ベゲタミン-A 配合錠, (Back) ベゲタミン A 配合錠 096
VEGETAMIN-B Combination Tablets(ベゲタミン-B配合錠) 
Brand name : VEGETAMIN-B Combination Tablets
 Active ingredient: Chlorpromazine hydrochloride
 Promethazine hydrochloride
 Phenobarbital
 Dosage form: white tablet, diameter: 9.2 mm, thickness: 5.2 mm
 Print on wrapping: (Face) ベゲタミン-B 配合錠, (Back) ベゲタミン B 配合錠 097
Effects of this medicine
This medicine contains 3 active ingredients that act on central nervous system. It relieves the symptoms such as feeling of anxiety, feeling of tension and feeling irritated by stabilizing mental status, and it induces sleep.
It is usually used for sedative and hypnotic effects on schizophrenia, senile psychosis, mania, depression or depressive state and neurosis.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have brain disorders (encephalitis, brain tumor, aftereffects following head injury, etc.).
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is <<to be written by a healthcare professional>>
•Sedation: In general, for adults, take 3 or 4 tablets daily in several divided doses.
Hypnosis: In general, for adults, take 1 or 2 tablets daily before bedtime.
In each case, the dosage may be adjusted according your disease, age and symptoms. Strictly follow the instructions.
•If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose. You should never take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so. Sudden discontinuation of taking this medicine may cause adverse events.
Precautions while taking this medicine
•Since this medicine may cause drowsiness or decreased attention and concentration, avoid driving a car or operating dangerous machinery.
•Alcohol may enhance the effects or the adverse reactions of this medicine.
•Since contacts with an organophosphate insecticide may enhance its toxicity, take care not to make contact with it.
•If you are breastfeeding, avoid breastfeeding while taking this medicine.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include nasal congestion, parkinsonian syndrome [finger shivering (tremor in hands), muscle rigidity (muscle stiffness)], dry mouth, constipation, malaise, rash and photosensitivity (exaggerated sunburn caused by sunlight, itch, pigmentation). If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•muscle stiffness, increased pulse, fever  [syndrome malin (neuroleptic malignant syndrome)]
•dizziness, palpitation, shortness of breath  [sudden death, ventricular tachycardia]
•palpitation and/or shortness of breath, yellowness in skin or in the white of eyes, nose and/or gum bleeding, fever, pain in throat  [aplastic anemia, hemolytic anemia, thrombocytopenia, agranulocytosis, decreased white blood cells]
•constipation, feeling of fullness in abdomen, severe pain in abdomen  [paralytic ileus]
•moving a tongue and sliding it in and out of a mouth, movement of a mouth like chewing continuously, body movement against one's will  [tardive dyskinesia, tardive dystonia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep the medicine out of the reach of infants and children. Store it at room temperature (1 to 30 degrees Celsius) away from direct sunlight and moisture.
•Discard the remainder. Do not store them. For disposal methods, consult the pharmacy or the medical institution from which you have received the medicine.

责任编辑:admin


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