AMINOLEBAN EN powder mix是多种营养粉混合组成-为新一代肝功能衰竭的口服营养物质，快速改善肝性脑病症状

治疗类别名称
口服营养物质肝功能衰竭
商標名
Aminoleban EN powder mix
组成
这种药物包含的组件，并在1包（50克）以下的量
L-异亮氨酸1.9225克
L-亮氨酸2.037克
* L-赖氨酸盐酸盐0.2425克
L-苏氨酸0.133克
L-缬氨酸1.602克
L-精氨酸盐酸0.302克
* L-组氨酸盐酸盐水合物0.1875克
L-色氨酸73.5mg
水解明胶6.5克
米面油3.5克
糊精31.05克
维生素A棕榈酸酯466I.U.
钙化醇46.6I.U.
二板凳胺0.145mg
核黄素0.155mg
盐酸吡哆辛0.245mg
氰钴胺素为0.5μg
叶酸为50μg
钠L-抗坏血酸为6.9mg
维生素E醋酸酯9.3mg
植物甲萘醌5.5μg
泛酸钙1.19mg
烟酰胺1.515mg
生物素为25μg
酒石酸氢胆碱12.3mg
硫酸镁水合物0.205克
甘油磷酸钙0.305克
磷酸二氢钠0.195克
柠檬酸钠铁12.5毫克
硫酸铜0.515mg
硫酸锌水合物3.755mg
碘化钾12.5μg
硫酸锰0.815mg
氯化钾0.1875克
添加剂
酪蛋白酸钠如，山梨酸钾，精制蔗糖，含有索马甜，硅树脂，脂肪酸蔗糖酯。
性状
本剂是一种白色至淡黄色粉末，有轻微的独特气味和味道。
该药物是当与水混合至淡黄色悬浮液的白色。pH为5.5至7.0溶解在常规浓度时约1kcal/毫升，约2的渗透压比。
适应病症
慢性肝衰竭患者的营养状况肝性脑病的改善
用法与用量
通常，溶解在1包（50克）的成年人约180ML水或热水作为单剂量（约200kcal/200ml）中，以口服摄取随餐服用，一天三次。
用量应适当地根据年龄和症状进行调整。
药效药理
1. 门静脉，下腔静脉吻合术作为慢性肝衰竭模型（PCS）的结果用在游离氨基酸浓度的血浆和大脑中的大鼠和狗，不平衡被施用校正分布式Aminoleban EN制剂，特别是脑的血清素代谢研究观察到的异常的改善
2. 氨负荷模型，对正常大鼠氨引起的昏迷，缩短抑制的趋势和昏迷发病昏迷持续时间趋势的影响的调查结果是通过行政部门分布观察EN Aminoleban混合。另外，在装载有氨在PCS大鼠，其通过施用漫射Aminoleban EN制剂抑制脑电图潜力的降低。
3. 使用缺血肝衰竭大鼠如，失调和脑胺在游离氨基酸浓度血浆和脑代谢异常进行校正由管理分布式Aminoleban EN共混检查急性肝功能衰竭模型的结果。
4. 作为慢性肝衰竭模型，调查通过使用PCS大鼠的结果，是由分布式Aminoleban EN配合连续给药观察到的体重增加，获得正氮平衡。此外，蛋白质的利用率也呈上升趋势。此外，连续给药分布式Aminoleban EN也混在装载有手术应激获得体重增加和正氮平衡，即使在四氯化碳诱导肝衰竭大鼠抑制体重减轻，正在PCS大鼠的手术后分解代谢相获得氮平衡。
5. 阻塞性黄疸的模式，即，使用胆总管结扎大鼠研究的结果，体重增加和正氮平衡是通过连续给药得到分布式Aminoleban EN共混。
包装规格
EN配混散：50克×21包装（镀铝袋）
制造厂商
大冢制药有限公司
注：以上中文资料仅供参考。使用以原处方资料为准；http://www.info.pmda.go.jp/go/pack/3259108B1039_1_03/

AMINOLEBAN EN powder mix（アミノレバンEN配合散） 
Brand name : AMINOLEBAN EN powder mix
　Active ingredient: Oral nutrient for patients with liver failure, consisting of amino acids, carbohydrates, lipids, electrolytes, and vitamins
　Dosage form: white to pale yellow powder
　Print on wrapping: アミノレバンEN配合散, 50g（粉末）, 約200kcal, 1包
Effects of this medicine
This medicine is rich in with branched-chain amino acids known to detoxify ammonia and promote protein synthesis, and it also contains carbohydrates, lipids, vitamins, and micronutrients for which dietary intake alone tends to be insufficient. The medicine supplements these nutritional components and enhances liver function to improve complications such as hepatic encephalopathy in patients with hepatic insufficiency.
It is usually used to improve nutritional state in patients with chronic hepatic insufficiency, including hepatic encephalopathy.
Before using this medicine, be sure to tell your doctor and pharmacist
•If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you have an allergy to milk.
•If you are pregnant or breastfeeding.
•If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)
Dosing schedule (How to take this medicine)
•Your dosing schedule prescribed by your doctor is ((to be written by a healthcare professional))
•In general, for adults, reconstitute one package (50 g) of this medicine at a time with approx. 180 mL of room-temperature water or warm water (approx. 50℃) and ingest 3 times daily with meals (approx. 200 kcal/200 mL). The dosage may be adjusted according to your disease, age, or symptoms. Strictly follow the instructions.
•Take the solution within 10 hours after preparation. If you should need to store the solution after preparation, store it in a cool place such as a refrigerator and take it within 10 hours.
•Do not reconstitute this medicine with hot water (hotter than approx. 50℃), as this will cause protein alterations.
•You may add some dietary flavoring (seasoning) or dietary fiber-rich vegetable according to your taste preference, but do not add fruit juice because the acidity may cause the solution to become gelatinous.
•If you have difficulty taking the solution due to the taste (particularly bitterness), reconstitute the medicine with approx. 230 mL of room-temperature water or warm water to prepare a solution at a concentration of approx. 0.8 kcal/mL (approx. 200 kcal/250 mL).
•If you miss a dose, take the dose as soon as you remember it. You should not take two doses at one time.
•If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
•Do not stop taking this medicine unless your doctor instructs you to do so.
Precautions while taking this medicine
•Follow the dietary instructions given by your hospital.
•As the daily dose (150 g) of this medication accounts for 40.5 g of protein and a total calorie intake of 630 kcal, take the remainder of your required daily nutrition through meals. Follow the dietary instructions of your doctor or dietitian regarding the content of your meals.
Possible adverse reactions to this medicine
The most commonly reported adverse reactions include rash, itch, diarrhea, bloating, nausea/vomiting, loss of appetite, epigastric pain/abdominal pain, edema, and headache/dull headache. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
•cold sweat, palpitation, trembling [hypoglycemia]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.
Storage conditions and other information
•Keep out of reach of children. Store away from direct sunlight, heat and moisture..
•Discard the remainder. Do not store them.
Otsuka Pharmaceutical Co., Ltd.Internal
Revised: 6/2015
The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.