英文药名: Elspar (Asparaginase Vials)

中文药名: 天门冬酰胺酶注射剂

药品简介

此药也叫:Leunase.
【别名】 天门冬酰胺酶, 左旋门冬酰胺酶,爱施巴, L-天门冬酰胺酶, 门冬酰胺酶
【外文名】L-Asparaginase , ASP, L-ASP, Elspar, Asparaginase, Leunase.

【适应症】 对急性粒细胞型白血病和急性单核细胞白血病也有一定疗效。对恶性淋巴瘤也有较好的疗效。其优点是对于常用药物治疗后复发的病例也有效，缺点是单独应用不仅缓解期短，而且很易产生耐药性，故目前大多与其他药物合并应用。对机体免疫有抑制作用，因而有人用来治疗皮肌炎等。

【用法用量】 可用于静注、静滴、肌注和鞘内注射。一般剂量：每千克体重２０～５０００单位或每平方米体表面积１００００～１５０００单位，每周３～７次。以每日每千克体重５００～１０００单位较佳。亦可每周应用１次，每次每千克体重２５００单位，一般以３～４周为１疗程。总剂量应根据所用药物的纯度和毒性而定。静注以等渗盐水２０～４０ｍｌ稀释，静滴以５％葡萄糖液或等渗盐水５００ｍｌ稀释。

【注意事项】
1.大肠杆菌门冬酰胺酶含有内毒素，故可引起发热现象。此外，还常有食欲减退、恶心、呕吐、腹泻等不良反应，有的病人有头痛、头昏、嗜睡、精神错乱等。由于门冬酰胺酶能影响蛋白质的合成和干扰脂质代谢，有的病人有血浆蛋白低下，血脂质过高或过低，氮质血症和肝功能损害。约１／３～１／２病人有骨髓抑制，表现为白细胞和血小板下降，有的病人可有贫血、凝血障碍、局部出血、感染等。有人报告有的病人有心血管系统症状、脱发、蛋白尿等，极少数病人且可发生胰腺炎。
2.可引起过敏反应，故用药前必须先用过敏试验，如有红肿、斑块，则为过敏反应。有过敏史的病人应十分小心或不用。
3.不同药厂、不同批号的产品，其纯度和过敏反应均有差异，使用时必须慎重。
4.有致畸胎作用，故妊娠早期应禁用。
5.肝、肾功能严重损害者忌用。
6.溶解后不宜长时间放置，以免丧失活力。

Elspar (Asparaginase Vials)

Drug Overview

Elspar belongs to the family of drugs known as an Antineoplastic drug which is also known as anticancer group of medicines and commonly used for the treatment of those people who suffered to the problems of several types of acute lymphocytic leukemia (ALL), with or without cancer. Elspar works by interfering with the growth of cancer cells, which are eventually destroyed.

Elspar is also used for the treatment of those people who suffered to the problems as acute myelogenous leukaemia and acute lymphoblastic leukaemia. Elspar can also be used to treat chronic granulocytic leukaemia. Leukaemia, or blood cancer, is a disease of unknown cause where the bone marrow produces large numbers of abnormal cells. These are different types of cancer affecting the blood. In people with blood cancer, abnormal blood cells are formed in the bone marrows which multiply uncontrollably, crowding out and interfering with the vital functions of normal healthy blood cells.

Elspar always takes under doctor’s guidance. Do not take more of it and do not take it for a longer time than your doctor ordered. The recommended doses of Elspar will be depends on body weight or different for different patients, according to the requirements of each patient; you continue to take it for as long as your doctor prescribes, even if you do not feel an immediate benefit. A typical starting dose for adults is 2 mg per kg body weight per day taken once daily. Your doctor will start you on a low dose of Elspar and gradually increase your dose. If you can not tolerate the recommended dosage, your doctor can prescribe a dose that sufficient for you. The generic name of Elspar is L-Asparaginase. Elspar is being manufactured by Merck and Co Inc and available in the form of Injections. Elspar may also be used for relieve other conditions that determined by your doctor or consultant.

Effects - How it works in the body

Elspar belongs to the family of drugs known as an Antineoplastic drug which is also known as anticancer group of medicines and commonly used for the treatment of those people who suffered to the problems of several types of acute lymphocytic leukemia (ALL), with or without cancer. Elspar works by interfering with the growth of cancer cells, which are eventually destroyed. Elspar kills cancer cells by attaching to a chemical within the cell and preventing it from using vital nutrients and other substances necessary for normal activity.

Side effects

Possible side effects during the uses of Elspar:

• Allergic reaction
• Abdominal or stomach pain
• Chest pain or discomfort
• Dizziness
• Fainting
• Fatigue
• Headache
• Hives
• Itching
• Loss of appetite
• Nausea
• Vomiting of blood
• Pale skin
• Rash
• Sore throat
• Swollen glands
• Black, tarry stools
• Blood in urine or stools
• Cough or hoarseness
• Fever or chills
• Lower back or side pain
• Painful or difficult urination
• Unusual bleeding or bruising
• Joint pain
• Swelling of feet or lower legs
• Yellow eyes or skin
• Unusual tiredness or weakness

Interactions

Although certain medicines should not be used together at all, so its your responsibilities that tell your doctor or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also you tell your doctor or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or addicted to illegal drugs. These may affect the working mechanism of Elspar. In these cases, your doctor may change the dose or teach precautions may be necessary. Therefore when you are taking Elspar, it is most important that your doctor or health care professional know if you are taking any of the following or other drugs:

• Probenecid or Benemid
• Sulfinpyrazone or Anturane
• Aspirin
• Acetaminophen
• Ibuprofen
• Ketoprofen
• Naproxen
• Cytarabine
• Methotrexate
• Vaccines
• Vincristine
• Warfarin

Counterindications

You shouldn’t use this medicine without consultation of doctor if you have an allergy to Elspar or any other ingredients of this medicine.

You shouldn’t use Elspar without consultation of doctor if you are suffering to the Kidney stones or kidney disease.

You shouldn’t use Elspar without consultation of doctor if you are suffering to the problem of liver disease.

You shouldn’t use Elspar without consultation of doctor if you are suffering to the problem of Heart disease.

You shouldn’t use Elspar without consultation of doctor if you are suffering to the problem of bleeding disorders.

You shouldn’t use Elspar without consultation of doctor if you are suffering to the problems of diabetes or other problems with blood sugar.

You shouldn’t use Elspar without consultation of doctor if you are suffering to the problems of Gout.

You shouldn’t use Elspar without consultation of doctor if you are suffering to the problems of pancreatitis.

You shouldn’t use Elspar without consultation of doctor if you are pregnant or plan to be pregnant.

You shouldn’t use Elspar without consultation of doctor if you are suffering to breastfeeding.

Similar drugs of Elspar

• Thioguanine
• Anandron
• Nilutamide
• Eulexin
• Cytomid
• Bicalutamide
• Casodex
• Nilandron
• Flutamide
• Arimidex
• Zoladex

Major drug Manufacturers

• Merck and Co Inc.
• Glaxo Smith Kline Pharmaceuticals
• Glaxo Wellcome Pharmaceuticals
• Catalytica Pharmaceuticals
• Aventis Pharmaceuticals
• Schering Plough Pharmaceuticals
• Astra-Zeneca Pharmaceuticals
• Hoechst Marion Roussel Pharmaceuticals (Norway)
• Cipla Pharmaceuticals

From where can one get Elspar?

Anyone can buy Elspar from Online Canadian Pharmacy, which is available at a discounted price, 50% off, in Canada, and the best way to get Elspar is by logging on to  for online orders. This pharmacy provides you with drugs at cheap and affordable prices. One can order the medicine and pay through VISA, MasterCard or international money order.

Why to buy Elspar drug from Canada?

It is cheaper to buy Elspar from Online Canadian Pharmacy, because Canadian government regulates the prices of Elspar and also because of the very common reason of exchange rate. Since, the Canadian dollar is cheaper as compared to the US Dollars, so one can buy more Elspar from Canada, there by saving a lot of money.