制造商：
眼力健
药理分类：
甾体抗炎药
活性成分（补）：
酮咯酸氨丁三醇0.45％;蛇夫座溶液，不含防腐剂。
指示（补）：
眼部疼痛和炎症后发性白内障手术。
药理作用：
酮咯酸氨丁三醇是一种非甾体抗炎药与镇痛，抗炎和抗解热属性（类固醇消炎药）。它被认为是前列腺素合成，通过发挥其治疗作用的抑制。
临床试验：
两个多中心，随机，双盲，平行分组进行了比较研究，以评估对前房细胞和光晕，和眼部疼痛缓解后的Acuvail影响后房型人工晶状体（IOL）植入术白内障摘除术。大约500名患者参加了这些研究。临床资料表明，Acuvail治疗的患者有前房炎症的发病率显着高于结算相比，谁收到车辆14天（53对26％的患者％分别）。 Acuvail也明显优于车辆在解决眼痛。在白内障手术后1天，72％的患者与Acuvail包括疼痛相比无与车辆40％的患者。
通过临床研究，酮咯酸氨丁三醇并没有表现出任何对眼压有显着影响。
法律分类：
接收
成人：
1滴，每天两次开始一天手术前，手术当天继续通过第2周后运。可能是管理结合其他专题眼科药（如α-受体激动剂，β-阻断剂，cycloplegics和mydriatics）;下降应给予至少5分钟的间隔。
儿童：
不推荐。
警告/注意事项：
不要管理，而戴上隐形眼镜。阿司匹林的敏感性。出血倾向。复杂或重复眼部手术。角膜缺陷/神经。眼表疾病。糖尿病。类风湿关节炎。可能会延迟伤口愈合。监视器角膜;停止，如果故障发生角膜上皮。妊娠（Cat.C）：避免在怀孕后期。哺乳的母亲。
互动（补）：
口服抗凝血剂，会增强，也有人认为延长出血。伴随外用类固醇可能会增加潜在的延迟愈合。
不良反应（补）：
眼压升高，结膜充血和/或出血，角膜水肿，角膜炎，眼痛，头痛，流泪，视力模糊，出血增多（包括hyphemas）。
如何提供：
一次性使用瓶（0.4mL）-30
最后更新：
2009年9月10日
ACUVAIL
Manufacturer:
Allergan
Pharmacological Class:
NSAID
Active Ingredient(s):
Ketorolac tromethamine 0.45%; oph soln; preservative-free.
Indication(s):
Ocular pain and inflammation after cataract surgery.
Pharmacology:
Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and anti-pyretic properties. It is thought to exert its therapeutic effects through inhibition of prostaglandin biosynthesis.
Clinical Trials:
Two multicenter, randomized, double-masked, parallel group comparison studies were conducted to evaluate the effects of Acuvail on anterior chamber cell and flare, and ocular pain relief following cataract extraction with posterior chamber intraocular lens (IOL) implantation. Approximately 500 patients were enrolled in these studies. Clinical data showed that patients treated with Acuvail had a significantly higher incidence of clearing of anterior chamber inflammation compared to those who received vehicle (53% versus 26% of patients, respectively) at Day 14. Acuvail was also significantly superior to vehicle in resolving ocular pain. On Day 1 after cataract surgery, 72% of patients treated with Acuvail were pain free compared to 40% of patients treated with vehicle.
Through clinical studies, ketorolac tromethamine has not demonstrated any significant effect on intraocular pressure.
Legal Classification:
Rx
Adults:
1 drop twice daily beginning 1 day prior to surgery, continue on day of surgery and through first 2 weeks post-op. May be administered in conjunction with other topical ophthalmic medications (eg, alpha-agonists, beta-blockers, cycloplegics, and mydriatics); drops should be administered at least 5 minutes apart.
Children:
Not recommended.
Warnings/Precautions:
Do not administer while wearing contacts. Aspirin sensitivity. Bleeding tendencies. Complicated or repeat ocular surgeries. Corneal defects/denervation. Ocular surface diseases. Diabetes. Rheumatoid arthritis. May delay wound healing. Monitor cornea; discontinue if corneal epithelial breakdown occurs. Pregnancy (Cat.C): avoid in late pregnancy. Nursing mothers.
Interaction(s):
May potentiate oral anticoagulants, others that prolong bleeding. Concomitant topical steroids may increase potential for delayed healing.
Adverse Reaction(s):
Increased intraocular pressure, conjunctival hyperemia and/or hemorrhage, corneal edema, keratitis, ocular pain, headache, tearing, blurred vision, increased bleeding (including hyphemas).
How Supplied:
Single-use vials (0.4mL)—30