英文药名: Maxalt(Rizatriptan Tablets)

中文药名: 利扎曲坦片
品牌药生产厂家: Merck Frosst

药品名称

产品名称: 苯甲酸利扎曲普坦
英文名称: Rizatriptan Monobenzoate
用途分类: 神经系统类/偏头痛
主要成份: 苯甲酸利扎曲普坦
药品简介

利扎曲坦（rizatriptan,maxalt），系美国默克公司研制，1998年10月在荷 兰首次上市的第4个获准上市的曲坦类药物。本品口服剂型生利用度约40%，而作用达峰时短至1小时，故起效快，给药后30分钟即可见13%-28%的患者症状明显改善。本品剂型有常规口服片和速溶片两种，剂量规格有5 mg和10 mg两种。
适应症

用于成人有或无先兆的偏头痛发作的急性治疗，不适用于预防偏头痛，不适用于半身不遂或基底部偏头痛患者。
用法用量

口服给药, 一次5-10mg（1-2粒），每次用药的时间间隔至少为2小时，一日最高剂量不得超过30mg（6粒），或遵医嘱。
不良反应

本品有很好的耐受性，不良反应轻且时间短暂，主要副作用是虚弱，易疲劳，嗜睡，有疼痛或压迫感及眩晕。严重的心脏意外，包括在使用5?HT1激动剂后出现死亡，这些事件极少发生。报道的病人多伴有冠状动脉疾病（CAD）危险因素先兆，意外事件有冠状动脉痉挛，短暂性心肌缺血，心肌梗死，室性心动过速及室颤。
禁忌症

1. 禁用于局部缺血性心脏并（如：心绞痛 心肌梗死或有记录的无症状缺血）的患者。
2. 禁用于有缺血性心脏病，冠状动脉痉挛（包括Prinzmetal变异型狭心症或其他隐性心血管疾病等）症状，体征的患者。
3. 因本品能升高血压，故不易控制血压的高血压患者禁用。
4. 禁用于半身不遂或基底部偏头痛患者。
5. 禁止同时服用MAO抑制剂，禁止在停服MAO抑制剂两周内服用本品。
6. 对本品或任一活性成分过敏者禁用。
7. 在服用本品治疗的24小时内，禁止服用其他5-HT1激动剂，含有麦角胺或麦角类药物如双氢麦角胺，美西麦角等。
药物相互作用

1. 由于普萘洛尔可使本品的血浆浓度增加70% 可在服用普萘洛尔同时服用本品5mg。
2. 含麦角的药物能延长血管痉挛反应，在服用本品24小时内不可同时服用含有麦角胺或麦角胺型药物（如双氢麦角胺 美西麦角）。
3. 其他5-HT1激动剂可以累积血管痉挛的作用，不推荐在24小时内联合服用本品和其他5-HT1激动剂。
4. 如果临床有正当理由准许本品与选择性5-羟色胺再吸收抑制剂（SSRLs）合用，应注意对病人进行严密观察。
5. 本品10mg与帕罗西汀同时服用后没有发现两者在临床或药理方面的相互作用。
6. 本品不能与MAO-A抑制剂，非选择性MAO抑制剂合用。

默沙东公司的苯甲酸酯利扎曲坦 (Rizatriptan、Maxalt)目前是美国治疗偏头痛的金标准。
Maxalt(Rizatriptan Tablets)是一种最新治疗偏头痛的世界级经典药物，突破性的特异性治疗偏头痛药物快速:快速缓解头痛和伴随症状高效:比其他曲坦类药物具有更好的疗效，临床应用更广。

Maxalt(rizatriptan)isusedfor:

Treating acute migraine headache with or without aura (flashing lights, wavy lines, dark spots) in adults. It should not be used to prevent migraines or cluster headaches.

Rizatriptan is a selective serotonin receptor agonist. It works by narrowing dilated blood vessels in the brain, relieving migraine headaches.

Do NOT use Rizatriptan if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rizatriptan :

Some medical conditions may interact with Rizatriptan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you are obese, postmenopausal, or a smoker
• if you have basilar artery or hemiplegic migraines, or cluster headaches
• if you have diabetes, kidney or liver problems, high cholesterol, high blood pressure, or a family history of coronary artery disease

Some MEDICINES MAY INTERACT with Rizatriptan . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they may decrease Rizatriptan 's effectiveness
• Beta-blockers (eg, propranolol), ergot alkaloids (eg, ergotamine), or MAOIs (eg, phenelzine) because they may increase the actions of Rizatriptan and the risk of Rizatriptan 's side effects
• Dexfenfluramine, ergot alkaloids (eg, ergotamine), or sibutramine because their actions and the risk of their side effects may be increased by Rizatriptan

HowtouseRizatriptan :

Use Rizatriptan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Rizatriptan . Talk to your pharmacist if you have questions about this information.
• Take Rizatriptan by mouth with or without food.
• Take Rizatriptan with plenty of fluid.
• Take a single dose of Rizatriptan as soon as migraine symptoms appear. A second dose may be taken if there is only a partial response or symptoms of the migraine return. However, do not take it sooner than 2 hours following the first dose. Do not take more than 30 milligrams (mg) in a 24-hour period.
• Do not take additional doses if you do not get a response from the first dose.
• If you miss a dose of Rizatriptan and you still have a headache, follow your doctor's dosing instructions. Contact your doctor right away if you are unsure of what to do if you miss a dose. Do not take Rizatriptan more often than prescribed. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rizatriptan .

Importantsafetyinformation:

• Rizatriptan may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Rizatriptan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Rizatriptan is not intended to prevent or reduce the number of migraine attacks that you experience.
• If you have a headache that is different from your usual migraine attacks, check with your doctor before using Rizatriptan .
• Diabetes patients - Rizatriptan may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change your diet or the dose of your diabetes medicine.
• Rizatriptan should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Rizatriptan while you are pregnant. It is not known if Rizatriptan is found in breast milk. If you are or will be breast-feeding while you use Rizatriptan , check with your doctor. Discuss any possible risks to your baby.

Possiblesideeffectsof

Rizatriptan :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; fatigue; nausea; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; changes in vision; chest pain, heaviness, or pressure; cold, tingling, or numb hands or feet; fainting or unsteadiness; fast or irregular heartbeat; pain or tightness in jaw or neck; seizure; stomach pain; unusual weakness.