泼尼松 【Prednisone】 【分类】肾上腺皮质激素及促肾上腺皮质激素药 【别名】强的松;去氢可的松,泼尼松 【外文名】Prednisone 【药理作用】抗炎、抗过敏作用强,水钠潴留副作用小。 【适应症】主要用于各种急性严重细菌感染,严重过敏性疾病,胶原性疾病(红斑狼疮、结节性动脉周围炎等),风湿病、类风湿性关节炎、肾病综合征,严重支气管哮喘、血小板减少性紫癜、粒细胞减少症、急性淋巴性白血病、各种肾上腺皮质功能不全症、剥脱性皮炎、天皰疮、神经性皮炎、湿疹等。 【用量用法】口服:用于治疗过敏性、炎症性疾病,成人开始每日15~40mg,需要时可增加到60mg,分次服用,病情稳定后逐渐减量。维持量每日5~10mg 【不良反应】长期大量服用引起柯兴氏征,诱发神经精神症状以及消化系统溃疡、骨质疏松、生长发育受抑制、并发和加重感染。 【注意事项】本品需经肝脏代谢活化为氢化泼尼松才能有效,故严重肝功能不良者不宜使用,其余同氢化可的松。与降糖药、抗癫痫药、噻嗪类利尿药、水杨酸盐、抗凝血药、强心甙等合用须考虑相互作用,应适当调整剂量。 【规格】片剂:5mg/片。 プレドニゾロン錠「タケダ」5mg/プレドニゾロン散「タケダ」1%包装 錠5mg : 100錠(10錠×10)、500錠(バラ、10錠×50) 散1% : 100g 製造販売元 ---------------------------------------------------------------
Main use:Rheumatoid arthritis Active ingredient:Prednisone Manufacturer:Napp Pharmaceuticals How does it work? Corticosteroids are hormones that are produced naturally by the adrenal glands. They have many important functions in the body, including control of inflammatory responses. Corticosteroid medicines are man-made derivatives of the natural hormones. They are often simply called steroids, but it should be noted that they are very different from another group of steroids, called anabolic steroids, which have gained notoriety because of their abuse by some athletes and body builders. Prednisone decreases inflammation by acting within cells to prevent the release of certain chemicals that are important in the immune system. These chemicals are normally involved in producing immune and allergic responses. By decreasing the release of these chemicals in a particular area, inflammation is reduced. This can help control a wide number of disease states characterised by excessive inflammation, including inflammation of the joints in arthritis. Arthritis symptoms of joint pain and stiffness are often worse first thing in the morning. Lodotra tablets are designed to release prednisone in a way that particularly helps with these morning symptoms. Lodotra tablets are modified-release tablets. They are designed to start releasing the prednisone about four to six hours after taking the tablet. You should take the medicine at bedtime so that the prednisone is released during the night. This will act on the inflammation over the night and will help to reduce the early morning joint pain and stiffness. What is it used for? How do I take it? The tablets should be swallowed whole with liquid. They should not be broken, crushed or chewed, as this will affect their modified-release action. The tablets should be taken with or after food. If two or three hours have passed since your evening meal then you should have a light snack before taking the tablets. Taking these tablets on an empty stomach can reduce the amount of prednisone absorbed into the blood and could make it less effective. Warning! You will be given a steroid card with this medicine that you should carry with you at all times. Show it to anyone who treats you (eg doctor, nurse, pharmacist, dentist or anaesthetist). The card contains details of your prescriber, type of steroid, dose taken and the duration of treatment. Its purpose is to act as a reminder that your medicine should not be stopped suddenly, and to provide information of your treatment to other people treating you. This is important because the effects that corticosteroids have on the body may affect other medical treatment you may be given. If you have an accident the card contains information that could save your life. You should also show your steroid card to anyone who treats you for three months after you stop treatment with steroids. During times of physical stress, for example illnesses, trauma or surgery, your adrenal glands would normally produce more steroid hormones to cope. However, during long-term treatment with this medicine the action of your adrenal glands will be suppressed, so this increase in hormones won't happen naturally. As a result your steroid dose will normally need to be increased temporarily during these kinds of events. Discuss this with your doctor. Corticosteroids decrease the body's natural immune and inflammatory responses. They may increase your susceptibility to infections and can also mask the symptoms of infections, making you think they are less serious than they are. For this reason, it is important to consult your doctor if you get any signs of infection during treatment. If you have never had chickenpox you could be at risk of severe chickenpox while having treatment with this medicine and should avoid close personal contact with people who have chickenpox or shingles (herpes zoster). You should also avoid contact with people who have measles. If you are exposed to people with these diseases either during treatment, or in the three months after stopping treatment, you should consult your doctor urgently, as you will need an injection of immunoglobulin to help you stop getting the diseases. This is very important as these diseases can be life-threatening in people treated with long-term corticosteroids. Corticosteroid treatment, especially with high doses, can alter mood and behaviour early in treatment. People may experience confusion, irritability, nightmares, difficulty sleeping, mood changes and depression, and suffer from delusions and suicidal thoughts. In a few cases these effects have also occurred when corticosteroid treatment is being withdrawn. For this reason, it is important to let your doctor know if you notice any change in your mood or behaviour during treatment or when stopping treatment, particularly if you begin to feel depressed, or have any disturbing thoughts or feelings. Most of these problems go away if the dose is lowered or the medicine is stopped. However if problems do happen they might need treatment. Use with caution in Not to be used in This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. Pregnancy and breastfeeding This medicine should be used with caution during pregnancy, and only if the expected benefit to the mother is greater than any possible risk to the developing baby. When administered for long periods or repeatedly during pregnancy, corticosteroids may increase the risk of slowed growth in the developing baby. They may also cause the baby to make less of its own steroid hormones after birth, though this usually resolves on its own and rarely causes any problems. Seek further medical advice from your doctor. If you think you could be pregnant while you are taking this medicine you should consult your doctor for advice. It is important that you do not suddenly stop taking the medicine unless your doctor tells you to - see the warnings above. This medicine passes into breast milk. It should be used with caution in mothers who are breastfeeding and only if the benefits to the mother outweigh any risks to the nursing infant. Doses of up to 10mg prednisone daily taken by the mother are unlikely to significantly affect the baby, but if the mother is taking higher than 10mg doses for long periods of time, the medicine could cause the baby's adrenal glands to make less of their own steroid hormones. Seek medical advice from your doctor. Label warnings Side effects Common (affect between 1 in 10 and 1 in 100 people) Uncommon (affect between 1 in 100 and 1 in 1000 people) Rare (affect between 1 in 1000 and 1 in 10000 people) The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist. How can this medicine affect other medicines? Prednisone can cause fluid and salt retention and so may oppose the effects of the following medicines: The following medicines may increase the removal of prednisone from the body, thus reducing its effects. You may need a larger dose of prednisone if you are also taking any of these medicines: There may be an increased chance of the level of potassium in the blood falling too low (hypokalaemia) if prednisone is used in combination with any of the following medicines, which can also lower the amount of potassium in the blood: If the amount of potassium in the blood falls too low as a result of taking prednisone, this can increase the risk of side effects from digoxin. Prednisone may increase blood sugar levels and so may oppose the blood sugar lowering effects of antidiabetic medicines such as insulin and metformin. People with diabetes may need an increase in their dose of insulin or antidiabetic tablets. Prednisone may enhance or reduce the anti-blood-clotting effect of anticoagulant medicines such as warfarin. People taking anticoagulant medicines in combination with prednisone should have their blood clotting time (INR) regularly monitored, particularly after starting or stopping treatment with prednisone and after any dose changes. If prednisone is used in combination with non-steroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, diclofenac or naproxen) there may be an increased risk of side effects on the gut, such as stomach ulceration and bleeding. Prednisone may decrease the blood levels of salicylates such as aspirin. When prednisone is stopped in people taking regular salicylates, the blood level of the salicylate may subsequently rise excessively, unless the dose is readjusted. Prednisone may decrease the body's immune response. This means that vaccines may be less effective if given during treatment, because the body does not produce sufficient antibodies. Live vaccines may cause serious infections. Live vaccines include: measles, mumps, rubella, MMR, BCG, chickenpox, oral polio, oral typhoid and yellow fever. These should not be given to people whose immune system is underactive due to treatment with this medicine. The effect of corticosteroids may be reduced in the three to four days following use of mifepristone. The following medicines may reduce the removal of prednisone from the body and so may increase its effects or side effects: The effect of the following medicines may be reduced by prednisone: Other medicines containing the same active ingredient |
泼尼松片LODOTRA(PREDNISONE)简介:
泼尼松 【Prednisone】【分类】肾上腺皮质激素及促肾上腺皮质激素药
【别名】强的松;去氢可的松,泼尼松
【外文名】Prednisone
【药理作用】抗炎、抗过敏作用强,水钠潴留副作用小。
【适应症】主要 ... 责任编辑:admin
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