NutreStore/L-glutamine(L-谷氨酰胺) -短肠综合症治疗药
主要成分：Ｌ－谷氨酰胺。
性状：片剂。
功能主治：用于治疗胃及十二指肠溃疡、胃炎及胃酸过多，也用于改善脑功能。
用法及用量：口服：每日１.５～２ｇ，与中和胃酸药合用可提高疗效。用于改善智力发育不良的儿童和精神障碍、酒精中毒、癫痫患者的脑功能，每日０.１～０.７２ｇ。
不良反应和注意：无毒副反应。
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L-Glutamine Power (Champion Nutrition) - General Information:
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cells. [PubChem]
Pharmacology:
Like other amino acids, glutamine is biochemically important as a constituent of proteins. Glutamine is also crucial in nitrogen metabolism. Ammonia (formed by nitrogen fixation) is assimilated into organic compounds by converting glutamic acid to glutamine. The enzyme which accomplishes this is called glutamine synthetase. Glutamine can then be used as a nitrogen donor in the biosynthesis of many compounds, including other amino acids, purines, and pyrimidines.
L-Glutamine Power (Champion Nutrition) for patients
L-Glutamine Power (Champion Nutrition) Interactions
Human growth hormone - Concomitant use of L-glutamine and human growth hormone may enhance nutrient absorption in those with severe short bowel syndrome. L-glutamine has orphan drug status for this indication. Indomethacin - Concomitant use of L-glutamine and indomethacin may ameliorate increased intestinal permeability caused by indomethacin. The reported dose used for L-glutamine was 21 grams daily taken in divided doses three times a day. Further, misoprostol is reported to have a synergistic effect with this combination in ameliorating intestinal permeability. Methotrexate - There is one report that methotrexate may decrease the possible effectiveness of supplemental L-glutamine for chemotherapy-induced mucositis. In another report, nine patients with breast cancer were reported to have decreased symptoms of methotrexate-related toxicity when given supplemental L-glutamine at a dose of 0.5 gram/kilogram/day. Paclitaxel - In one report, L-glutamine at a dose of 10 grams three times daily, given 24 hours after receiving paclitaxel, appeared to prevent the development of myalgia and arthralgia, adverse reactions of paclitaxel.
L-Glutamine Power (Champion Nutrition) Contraindications
Supplemental L-glutamine is contraindicated in those hypersensitive to any component of a glutamine-containing product.
Additional information about L-Glutamine Power (Champion Nutrition)
L-Glutamine Power (Champion Nutrition) Indication: Used for nutritional supplementation, also for treating dietary shortage or imbalance.
Mechanism Of Action: Supplemental L-glutamine's possible immunomodulatory role may be accounted for in a number of ways. L-glutamine appears to play a major role in protecting the integrity of the gastrointestinal tract and, in particular, the large intestine. During catabolic states, the integrity of the intestinal mucosa may be compromised with consequent increased intestinal permeability and translocation of Gram-negative bacteria from the large intestine into the body. The demand for L-glutamine by the intestine, as well as by cells such as lymphocytes, appears to be much greater than that supplied by skeletal muscle, the major storage tissue for L-glutamine. L-glutamine is the preferred respiratory fuel for enterocytes, colonocytes and lymphocytes. Therefore, supplying supplemental L-glutamine under these conditions may do a number of things. For one, it may reverse the catabolic state by sparing skeletal muscle L-glutamine. It also may inhibit translocation of Gram-negative bacteria from the large intestine. L-glutamine helps maintain secretory IgA, which functions primarily by preventing the attachment of bacteria to mucosal cells. L-glutamine appears to be required to support the proliferation of mitogen-stimulated lymphocytes, as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma). It is also required for the maintenance of lymphokine-activated killer cells (LAK). L-glutamine can enhance phagocytosis by neutrophils and monocytes. It can lead to an increased synthesis of glutathione in the intestine, which may also play a role in maintaining the integrity of the intestinal mucosa by ameliorating oxidative stress. The exact mechanism of the possible immunomodulatory action of supplemental L-glutamine, however, remains unclear. It is conceivable that the major effect of L-glutamine occurs at the level of the intestine. Perhaps enteral L-glutamine acts directly on intestine-associated lymphoid tissue and stimulates overall immune function by that mechanism, without passing beyond the splanchnic bed.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: L-Glutamine
Synonyms: 2-Aminoglutaramic acid; Glutamine
Drug Category: Dietary supplement; Micronutrient; Non-Essential Amino Acids
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing L-Glutamine: Glutamine Fuel Powder (Twinlab); Glutamine Fuel Mega (Twinlab); Glutamine Express (Genetic Evolutionary Nutrition); L-Glutamine Power (Champion Nutrition); Earthlink Science Glutamine Chews Chocolate (Amerifit); Cebrogen; Stimulina; Glavamin;
Absorption: Absorption is efficient and occurs by an active transport mechanism
Toxicity (Overdose): Doses of L-glutamine up to 21 grams daily appear to be well tolerated. Reported adverse reactions are mainly gastrointestinal and not common. They include constipation and bloating. There is one older report of two hypomanic patients whose manic symptoms were exacerbated following the use of 2 to 4 grams daily of L-glutamine. The symptoms resolved when the L-glutamine was stopped. These patients were not rechallenged, nor are there any other reports of this nature.
Protein Binding: Not Available
Biotransformation: Enterocytes, Hepatic
Half Life: Not Available
Dosage Forms of L-Glutamine Power (Champion Nutrition): Not Available
Chemical IUPAC Name: (2S)-2,5-diamino-5-oxopentanoic acid
Chemical Formula: C5H10N2O3
Generic Name for NUTRESTORE
L-glutamine 5g; per packet; pwd for oral solution.
Legal Classification:
Rx
Pharmacological Class for NUTRESTORE
Amino acid.
Manufacturer of NUTRESTORE
Emmaus Medical
Indications for NUTRESTORE
Short bowel syndrome in conjunction with nutritional support and recombinant human growth hormone therapy.
Adult dose for NUTRESTORE
Take with food at 2–3 hour intervals while awake. 30g/day in divided doses (5g taken 6 times daily) for up to 16 weeks; may delay dose up to 2 hours if transiently intolerant to oral intake.
Children's dosing for NUTRESTORE
Not recommended.
Warnings/Precautions for NUTRESTORE
Not for parenteral use. Renal or hepatic impairment (monitor). Labor and delivery. Pregnancy (Cat.C). Nursing mothers.
Adverse Reactions for NUTRESTORE
Infection, GI events (eg, tenesmus, flatulence), fever, depression, headache, hypoesthesia, pruritus, nail disorder.
How is NUTRESTORE supplied?
Packets—84
通用名称为NUTRESTORE
L -谷氨酰胺5G;每包; PWD口服液。
法律分类：
接收
类药物为NUTRESTORE
氨基酸。
制造商的NUTRESTORE
厄玛乌医疗
主治为NUTRESTORE
结合营养支持和重组人生长激素治疗短肠综合症。
该药与重组人生长激素（rh-Gh)联合用于治疗正在治接受特殊的营养支持的短肠综合征(sbs)
成人剂量为NUTRESTORE
每隔2-3小时清醒时采取食物。 30g/day在长达16周的剂量（5克采取每天6次）;可能会延迟剂量长达2个小时，如果瞬时耐受误服。
儿童剂量为NUTRESTORE
不推荐。
为NUTRESTORE警告/注意事项
不适用于肠外使用。肾或肝功能不全（显示器）。劳动和交付。怀孕（Cat.C）。哺乳的母亲。
NUTRESTORE的不良反应
感染，胃肠道事件（例如，里急后重，胀气），发烧，抑郁，头痛，感觉减退，皮肤瘙痒，指甲疾病。
如何NUTRESTORE提供？
数据包 - 84