依前列醇
【拉丁名】Epoprostenol
【别名】前列环素，PGI2，PLOLAN
【作用和用途】有抗血小板和舒张血管作用。可防止血栓生成。
用于治疗某些心血管疾病时作为抗血小板药，以防止高凝状态。也用于缺血性心脏病，原发性肺动脉高压、血小板消耗性疾病等。
【用法】静滴：每分钟5ng/kg，用量视病情而定。
【副作用及注意事项】有低血压、心率加快、面部潮红等不良反应，有时有胃肠道不适。
flolan
Uses
Flolan is used to treat a type of high blood pressure in the lungs (pulmonary hypertension). It works by causing the blood vessels (arteries)
in the lungs to relax and expand, thus decreasing the pressure.

Storage
Store unopened vials at room temperature between 59 and 77 degrees F (15 to 25 degrees C) away from light and moisture.
Do not freeze.
Consult your pharmacist for details regarding the stability of Flolan after dilution in correct IV fluids.
Discard any unused fluid.
      
Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.
Symptoms of overdose may include: severe dizziness, loss of consciousness.
How To Use
Inject Flolan directly into a vein (IV) continuously, using an infusion pump, or use as directed by your doctor.
Flolan should be started in a hospital/clinic.
Do not suddenly decrease the dose or stop using Flolan, unless directed to do so by your doctor.
Stopping Flolan, even briefly, may lead to serious side effects (see Side Effects section).
To avoid interruptions in drug treatment, you should have access to a backup infusion pump and infusion sets should your equipment fail.
Consult your doctor or pharmacist for more information.
Depending on your condition, you may be given other medications to help prevent blood clots (embolism).
Take all prescribed medication exactly as directed.
Learn all preparation and usage instructions, including how to prepare and administer Flolan and how to care for the injection site (central
venous catheter) and avoid infection.
If any of the information about the use of Flolan is unclear, consult your doctor or pharmacist.
Follow all instructions for proper mixing and dilution with correct IV fluids.
Learn how to store and discard needles and medical supplies safely.
If you have questions regarding the use of Flolan, consult your pharmacist.
Before using, check this product visually for particles or discoloration.

If either is present, do not use the liquid.

Side Effects
Nausea, headache, vomiting, loss of appetite, diarrhea, dizziness, jaw pain, flushing, sweating, drowsiness, joint/muscle aches, or
redness/swelling/pain at the injection site may occur.
If any of these effects persist or worsen, notify your doctor promptly.
Tell your doctor immediately if any of these serious side effects occur: stomach pain, chest pain, vision changes, fast/slow/irregular pulse,
mental/mood changes, changes in the appearance of the skin (e.g., unusual paleness or blue/grey color), signs of flu (e.g., chills, fever, sore throat), unusual bleeding or bruising, tingling /numbness/loss of feeling in hands or feet.
Tell your doctor immediately if any of these unlikely but serious side effects occur: unusual fatigue or weakness, enlarged abdomen, unexplained weight gain/loss.
An allergic reaction to Flolan is unlikely, but seek immediate medical attention if it occurs.
Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing.
Do not suddenly stop using Flolan or decrease the dose unless directed to do so by your doctor.
Serious effects such as trouble breathing, dizziness, or weakness may occur, which rarely may lead to death, if Flolan is suddenly stopped or
interrupted even briefly.
Contact your doctor or pharmacist immediately if your dose is interrupted or if you develop these side effects.
If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions
Flolan should not be used if you have the following medical conditions: certain types of congestive heart failure (left ventricular systolic
dysfunction), certain lung problems (pulmonary edema).
Tell your doctor your medical history, especially of: bleeding problems, liver disease, any allergies.
Flolan may make you dizzy or drowsy or cause changes in vision; use caution engaging in activities requiring alertness such as driving or
operating machinery.
Limit alcoholic beverages.
Flolan should be used only when clearly needed during pregnancy.
Discuss the risks and benefits with your doctor.
It is not known whether Flolan passes into breast milk.
Consult your doctor before breast-feeding.

Missed Dose
Flolan is to be given continuously into a vein.
If your dose is interrupted, contact your doctor or pharmacist immediately to establish new dosing.

Drug Interactions
Tell your doctor of all prescription and nonprescription medication you may use, especially: water pills (e.g., furosemide, torsemide), blood
thinners (e.g., warfarin, heparins), blood pressure medication (e.g., captopril, lisinopril, nifedipine), vasodilators (e.g., hydralazine,
nitrates), digoxin.
Also report any drugs that cause drowsiness, such as: medicine for sleep (sedatives), tranquilizers, anti-anxiety drugs (e.g., alprazolam,
diazepam), narcotic pain relievers (codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine or tricyclics such as
amitriptyline), anti-seizure drugs (e.g., carbamazepine, phenobarbital), muscle relaxants, antihistamines that cause drowsiness (e.g.,
chlorpheniramine, diphenhydramine).
Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients.
Ask your pharmacist about the safe use of those products.
Do not start or stop any medicine without doctor or pharmacist approval.
flolan
用途
Flolan是用于治疗在肺（肺高压）高血压类型。它的工作原理导致血管（动脉肺部）放宽和扩大，从而减少压力。

存储
存储未打开瓶在室温和77至59华氏度（15至25摄氏度）距离温度和湿度的光线。
不要冻结。
有关您能够获得稳定的Flolan细节药剂师正确后静脉注射液稀释。
丢弃任何未使用的液体。
      
过量
如果过量怀疑，请联系当地中毒控制中心或急诊室立即。
过量的症状可能包括：严重的头晕，意识丧失。
如何使用
注入Flolan直接进入静脉（四）不断，使用输液泵，或使用的指示你的医生。
Flolan应开始在医院/诊所。
不要突然减少剂量或停止使用Flolan，除非指示做你的医生做。
停止Flolan，甚至简单地说，可能会导致严重的副作用（见副作用节）。
为了避免药物治疗中断，你应该获得一个备份输液泵和输液器应您的设备故障。
请咨询您的医生或药剂师获取更多信息。
在您的病情而定，你可能得到的其他药物，以预防血栓（栓塞）。
采取一切严格按照规定的用药指导。
了解所有的准备和使用说明，包括如何准备和管理Flolan以及如何照顾注射部位（中央静脉导管），避免感染。
如果对Flolan使用任何资料•不清楚，请教医生或药剂师。
遵循适当混合和正确的静脉注射液稀释的所有指示。
了解如何存储和丢弃的针头和医疗用品的安全。
如果你有问题就Flolan使用，请咨询您的药剂师。
在使用前，检查视力的颗粒或变色此产品。
如果不是存在，不使用液体。

副作用
恶心，头痛，呕吐，食欲不振，腹泻，头晕，颌部疼痛的损失，脸红，出汗，嗜睡，关节/肌肉疼痛，或发红/肿胀/在注射部位疼痛，可能会出现。
如果这些效果是否持续或恶化，及时通知你的医生。
请告知你的医生立即如果这些严重的副作用，任何发生：腹痛，胸痛，视力变化，快/慢/不规则的脉搏，精神/情绪变化，在皮肤外观的变化（例如，不寻常的苍白或蓝色/灰色），对禽流感的迹象（例如，发冷，发热，喉咙痛），不寻常的出血或瘀伤，刺痛/麻痹/的手或脚的感觉丧失。

请告知你的医生立即如果这些不可能的，但任何严重的副作用发生：不寻常的疲劳和虚弱，腹部增大，体重增益/损耗。
过敏反应Flolan是不可能的，但尽快求医，如果它发生。
对过敏反应的症状包括：皮疹，瘙痒，肿胀，严重的头晕，呼吸困难。
不要突然停止使用Flolan或减少剂量指示做，除非你的医生做。
严重，如呼吸困难，头晕，或弱点的影响，可能会出现，而很少可能会导致死亡，如果Flolan突然停止或中断，甚至简单。
联系你的医生或药剂师，如果您的剂量立即中断或如果你开发这些副作用。
如果您发现上面未列出的其他影响，请与您的医生或药剂师。

注意事项
Flolan不应使用，如果您有以下医疗条件：充血性心力衰竭的某些类型（左心室收缩功能不全），某些肺部问题（肺水肿）。
告诉您的医生，尤其是您的病史：出血问题，肝病，任何过敏。
Flolan可能使你晕眩或昏昏欲睡，或导致视力的变化，一定要小心从事的活动的警觉性，如驾驶或操作机器的需要。
限制酒精饮料。
Flolan应只在怀孕时，显然需要。
讨论的风险和你的医生的利益。
它不知道是否Flolan进入乳汁通行证。
你的医生咨询前母乳喂养。

错过剂量
Flolan是要放弃把静脉不断。
如果你的剂量被中断，请与您的医生或药剂师立即建立新的剂量。

药物相互作用
告诉您的医生对所有处方药和非处方药可以使用，特别是：水药片（如呋塞米，托拉塞米），血液稀释剂（如华法林，肝素），血压药物（如卡托普利，赖诺普利，硝苯地平），血管扩张剂（例如，肼苯哒嗪，硝酸盐），地高辛。

还报告任何药物，引起昏睡，如：睡眠药（镇静剂），镇静剂，抗焦虑药物（如阿普唑仑，地西泮），麻醉止痛剂（可待因），精神药品（例如，如氯丙嗪或噻嗪如阿米替林三环），抗惊厥药物（如卡马西平，苯巴比妥），肌肉松弛剂，抗组织胺引起嗜睡（如扑尔敏，苯海拉明）。

检查您的所有药品的标签（例如，咳嗽和-）冷的产品，因为它们可能包含昏昏欲睡致癌成分。
向您对这些产品的安全使用药剂师。
不要启动或停止未经批准的医生或药剂师任何药物。