药品信息: 友情提示：该药是严格管制药，应用时请谨慎或医嘱！ Manufacturer: Shire  Indication: ADHD  Active Ingredient: Phase: III  Pharmacology After oral administration, lisdexamfetamine is rapidly absorbed from the GI tract and is converted to the active drug dextroamphetamine. Amphetamines are thought to block the reuptake of norepinephrine and dopamine into presynaptic neurons and increase the release of these neurotransmitters into the synapse. The mechanism of action of the amphetamines in treating the symptoms of ADHD has not been established.        Clinical Trials In a double-blind, parallel-group study, children 6–12 years old who met the DSM-IV criteria for ADHD were given either fixed-dose lisdexamfetamine or placebo once daily in the AM for 4 wks. Significant improvements in behavior were seen for all doses for lisdexamfetamine compared to placebo; these improvements were maintained throughout the day, up to approximately 6pm. Both investigator rating scales and a parent rating scale was used to assess efficacy. In a crossover study conducted in children 6–12 years of age who met DSM-IV criteria for ADHD, the effectsoflisdexamfetamine and Adderall-XR were compared to those of placebo. After a 3-week open-label dose-titration phase during which Adderall-XR was given, patients were randomized to continue the same dose of Adderall-XR (10mg, 20mg, or 30mg) or they were switched to lisdexamfetamine 30mg, 50mg, 70mg, or placebo. Across the eight sessions of a 12-hour treatment day, a significant difference in behavior between those given lisdexamfetamine and those given placebo was seen. Adverse Reactions Cardiovascular and CNS effects (eg, psychosis, tics, dizziness, insomnia, irritability) GI upset, rash, upper abdominal pain, decreased appetite/weight, anticholinergic effects (eg, blurred vision, dry mouth).        Adults >12yrs: not recommended.        Children <6 yrs: not recommended. 6–12yrs: 30mg once daily in AM. May increase at intervals of 1 week by 20mg/day; max 70mg/day. May dissolve contents of capsule in water, take immediately (do not subdivide caps).        Contraindications Advanced arteriosclerosis. Symptomatic cardiovascular disease. Moderate to severe hypertension. Structural heart defects. Arrhythmias. Hyperthyroidism. Glaucoma. Agitation. Drug abusers. Hypersensitivity or idiosyncrasy to sympathomimetics. Within 14 days of MAOIs. Precautions Bipolar disorder. Psychoses. Tourette's syndrome. Tics. Hypertension. Heart failure. Recent MI. Seizures. Drug abusers. Impaired renal, hepatic, or thyroid function. Reevaluate periodically. Monitor growth, BP, heart rate, worsening aggressive behavior or hostility. Write Rx or smallest practical amount. Pregnancy (Cat.C). Nursing mothers: not recommended. InteractionsSee Contraindications. Hypertensive crisis with MAOIs, furazolidone. Potentiated by tricyclics, propoxyphene. Potentiates meperidine, norepinephrine, phenobarbital, phenytoin, tricyclics. Antagonized by urinary acidifiers, psychotropics (eg, haloperidol, chlorpromazine), lithium. Antagonizes adrenergic blockers, antihistamines, antihypertensives. Monitor phenytoin, ethosuximide, phenobarbital. Convulsions with propoxyphene overdose. Caution with other sympathomimetics. May interfere with urinary steroid tests. Vyvanse用于成人注意缺陷多动障碍的维持治疗 FDA批准兴奋药lisdexamfetamine dimesylate（Vyvanse）用于成人注意力缺陷多动障碍的维持治疗。 此次获准是基于一项药效验证研究。研究纳入18-55岁注意力缺陷多动障碍的维持治疗患者，为期6个月。研究显示，相比安慰剂组，本品能够较好控制ADHD症状，而且患者症状的复发率也达到了研究终点。研究显示服用lisdexamfetamine dimesylate（Vyvanse）的患者，其症状在6个月内保持稳定。随机接受治疗的话，lisdexamfetamine dimesylate（Vyvanse）组高达91%的患者症状稳定，而安慰剂组的只有25%。 成人注意力缺陷多动障碍需要长期治疗，选择一个有效的维持治疗药物对病人有好处得到收益。本品可以用于治疗6岁及6岁以上的注意力缺陷多动障碍患者。 附件： 20082517042726.pdf    --------------------------------------------------------------- 注：以下产品不同规格和不同价格，购买以咨询为准！ --------------------------------------------------------------- 产地国家: 英国 原产地英文商品名: Vyvanse 20MGx100Capsules 原产地英文药品名: lisdexamfetamine dimesylate 中文参考商品译名: Vyvanse 20毫克x100胶囊/瓶 中文参考药品译名: lisdexamfetamine dimesylate 生产厂家中文参考译名: Shire Pharmaceuticals 生产厂家英文名: Shire Pharmaceuticals --------------------------------------------------------------- 产地国家: 英国 原产地英文商品名: Vyvanse 30MGx100Capsules 原产地英文药品名: lisdexamfetamine dimesylate 中文参考商品译名: Vyvanse 30毫克x100胶囊/瓶 中文参考药品译名: lisdexamfetamine dimesylate 生产厂家中文参考译名: Shire Pharmaceuticals 生产厂家英文名: Shire Pharmaceuticals --------------------------------------------------------------- 产地国家: 英国 原产地英文商品名: Vyvanse 40MGx100Capsules 原产地英文药品名: lisdexamfetamine dimesylate 中文参考商品译名: Vyvanse 40毫克x100胶囊/瓶 中文参考药品译名: lisdexamfetamine dimesylate 生产厂家中文参考译名: Shire Pharmaceuticals 生产厂家英文名: Shire Pharmaceuticals --------------------------------------------------------------- 产地国家: 英国 原产地英文商品名: Vyvanse 50MGx100Capsules 原产地英文药品名: lisdexamfetamine dimesylate 中文参考商品译名: Vyvanse 50毫克x100胶囊/瓶 中文参考药品译名: lisdexamfetamine dimesylate 生产厂家中文参考译名: Shire Pharmaceuticals 生产厂家英文名: Shire Pharmaceuticals --------------------------------------------------------------- 产地国家: 英国 原产地英文商品名: Vyvanse 60MGx100Capsules 原产地英文药品名: lisdexamfetamine dimesylate 中文参考商品译名: Vyvanse 60毫克x100胶囊/瓶 中文参考药品译名: lisdexamfetamine dimesylate 生产厂家中文参考译名: Shire Pharmaceuticals 生产厂家英文名: Shire Pharmaceuticals --------------------------------------------------------------- 产地国家: 英国 原产地英文商品名: Vyvanse 70MGx100Capsules 原产地英文药品名: lisdexamfetamine dimesylate 中文参考商品译名: Vyvanse 70毫克x100胶囊/瓶 中文参考药品译名: lisdexamfetamine dimesylate 生产厂家中文参考译名: Shire Pharmaceuticals 生产厂家英文名: Shire Pharmaceuticals 该药品相关信息网址1: http://www.Vyvanse.com