产品名称：  二甲磺酸赖右苯丙胺
英文名称：  Lisdexamfetamine dimesylate
别  名：  赖右苯丙胺二甲磺酸盐;赖氨酸安非他命甲磺酸盐;甲磺酸赖氨酸安非他命,(2S)-2,6-Diamino-N-[(1S)-1-methyl-2-phenylethyl]hexanamide dimethanesulfonate
结 构 式：  

分 子 式：  C15H25N3O.2(CH4O3S)
分 子 量：  455.59 

FDA已批准Shire公司的注意力不集中/多动症(ADHD)治疗新药Vyvanse上市，该药每日用药一次，剂量分别有30毫克、50毫克和70毫克三种。

2010年11月FDA批准新药二甲磺酸赖右苯丙胺（Vyvanse，Lisdexamfetamine dimesylate）

苯丙胺衍生物二甲磺酸赖右苯丙(1isdexamfetaminedimesylate，原称为NRP104)胶囊(商品名：Vyvanse)上市。用于治疗儿童注意力不集中伴多动症(AD—HD)。

Vyvanse为无治疗作用的前体药物。口服后在胃肠道内被迅速吸收转化成右苯丙胺才发挥作用。新河制药公司设计了二甲磺酸赖右苯丙胺ADHD治疗新药：将右苯丙胺以共价键连接在L一赖氨酸分子上。早上口服本品后，较安慰剂显著有效，且可整日(至下午6点)保持疗效。在两项口服和静脉注射给药的药物滥用临床研究中，患者对Vyvanse产生的药物喜欢作用(druglikingeffects，DLE)记分较相同剂量的右苯丙胺小。
Ⅱ期和Ⅲ期临床研究显示，以Vyvanse治疗6～12岁患者较安慰剂在统计学上显著改善ADHD症状。所有剂量(30mg，50mg，70mg)的Vyvanse在服用的任何时间点(包括下午6点)均显著有效。在随机双盲安慰剂对照Ⅲ期临床研究中，所有三种剂量的Vyvanse一日1次治疗4周后的ADHD等级记分(ADHD—RS—IV)较安慰剂显著改善(P<0．0001)。此外，在2006年10月重要科技会议上介绍的研究成果显示，一开放式Ⅲ期临床研究接受Vyvanse6个月治疗的6～12岁患儿改善ADHD症状的主要等级记分达60％。结果还显示，在服用VyvaBSe6个月时95％)L童产生“很大”或“非常大”改善全球临床综合印象量表——提高记分。

【原产地英文商品名】Vyvanse apsules
【原产地英文药品名】lisdexamfetamine dimesylate
【中文参考商品译名】
注：以下产品不同规格和不同价格，购买时请以电话咨询为准！
·Vyvanse 70毫克x100胶囊/瓶
·Vyvanse 60毫克x100胶囊/瓶
·Vyvanse 50毫克x100胶囊/瓶
·Vyvanse 40毫克x100胶囊/瓶
·Vyvanse 30毫克x100胶囊/瓶
·Vyvanse 20毫克x100胶囊/瓶
【中文参考药品译名】lisdexamfetamine dimesylate
【生产厂家中文参考译名】Shire Pharmaceuticals
【生产厂家英文名】Shire Pharmaceuticals

Vyvanse is a central nervous system stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

Vyvanse is used to treat attention deficit hyperactivity disorder (ADHD) in adults and in children who are 6 to 12 years old. It is used as a part of a total treatment program that may include psychological, educational, and social therapy.

Vyvanse may also be used for other purposes not listed in this medication guide.

Most important: Do not use Vyvanse if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take Vyvanse before the MAO inhibitor has cleared from your body. Do not use Vyvanse if you are allergic to lisdexamfetamine, or if you have hardened arteries (arteriosclerosis), heart disease, moderate to severe high blood pressure (hypertension), overactive thyroid, glaucoma, severe anxiety or agitation, or a history of drug or alcohol addiction. Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects. Before taking Vyvanse, tell your doctor if you have any type of heart problems.

Vyvanse is a drug of abuse and may be habit-forming. Keep track of the amount of medicine used from each new bottle. You should be aware if anyone is using your medicine improperly or without a prescription. Using Vyvanse improperly can cause death or serious side effects on the heart.