【商品名称】安体舒通（spironolactone) 【适应症状】雄性激素源性脱发、脂溢性脱发及脂溢性皮炎、痤疮及妇女多毛症等 【简要说明】又称螺旋内酯固醇，一直被用来治疗高血压。对其功效的新发现有多项，其中之一就是对抗雄性激素制剂,用来竞争性抑制和阻断二氧睾酮与毛囊受体的结合而发挥治疗作用。雄性激素源性脱发、脂溢性脱发除了与糠秕孢子菌感染有关外，皮脂腺分泌功能亢进是主要原因。皮脂腺是雄激素的直接靶器官，安体舒通可通过抗雄性激素作用使皮脂腺的分泌量减少从而达到保护毛囊抑制脱发的发生。（有临床报道，用安体舒通每日40—60毫克，连续服用3--6个月， 治愈率及显效率均分别达60．8％和40％，其表现为脱发停止，并有新发长出，头发及头皮油腻瘙痒感明显减轻。治疗中及治疗后查血、尿常规及血钾、肝功能均正常） 【包装规格】100粒/瓶（分25mg/粒装和100mg/粒 装） 【使用方法】每次25mg,一日三次.连续服用3-6个月 【价格】 （25mg/粒装）100元/瓶              （100mg/粒装）330元/瓶 What is Spironolactone? Spironolactone is a diuretic used in the treatment of congestive heart failure (CHF), and ascites (fluid in the abdomen). Spironolactone requires a prescription from your veterinarian.  For: Cats and Dogs   Benefits: • Easy to administer • Also used to treat edema and high blood pressure • Does not cause loss of potassium How it works: Spironolactone inhibits the effect of aldosterone, a hormone that causes the tubules of the kidneys to retain sodium and water. This increases the excretion of water and sodium, while decreasing the excretion of potassium. Cautions: Tell your veterinarian if your pet has kidney or liver disease, diabetes mellitus, high levels of potassium in the blood, or if your pet is being given a potassium supplement or an ACE inhibitor such as enalapril or lisinopril. Tell your veterinarian if your pet is pregnant or lactating. Spironolactone will cause your pet to urinate more often, and your pet may have more "accidents" and need to go outside or use the litter box more. Make sure that your pet eats and drinks well while taking spironolactone or the risk of side effects increases. -------------------------------------------------------------------------------- More Information: Brand Name Aldactone (Pharmacia)   Generic Name Spironolactone (spy-rone-oh-lack-tone) What is the most important information I should know about Spironolactone: Spironolactone is a prescription medication that is not FDA approved for use in animals; however, it is a commonly accepted practice for veterinarians to use spironolactone in dogs and cats. Spironolactone is available as 25mg tablets. The usual dose in dogs and cats is 0.5-1mg per pound every 12 hours. Give spironolactone with food to lessen stomach upset. What is Spironolactone: Spironolactone is a potassium-sparing diuretic (water pill). Spironolactone is used to reduce the amount of fluid in the body without also causing a loss of potassium. Spironolactone is used in the treatment of edema and high blood pressure (hypertension). Spironolactone is also used to treat potassium deficiency and hyperaldosteronism. Spironolactone may also be used for purposes other than those listed in this guide. What should I discuss with my veterinarian before giving spironolactone to my pet:  Tell your veterinarian if your pet has kidney or liver disease, diabetes mellitus, high levels of potassium in the blood, or if the pet is being given a potassium supplement or an ACE inhibitor such as enalapril or lisinopril. Tell your veterinarian if your pet is pregnant or lactating. How should this medication be given: Give this medication exactly as directed by your veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Spironolactone should be taken with food to lessen stomach upset. Keep plenty of water available for your pet. Do not suddenly stop giving this medication. Stopping suddenly could make the condition worse. Store spironolactone at room temperature, away from moisture and heat. Keep this medication away from children and pets. What happens if I miss giving a dose: Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication. What happens if I overdose the pet: Seek emergency veterinary medical treatment. Symptoms of spironolactone overdose include an irregular heartbeat, lethargy, fatigue, weakness, drowsiness, dizziness, confusion, shortness of breath, nausea and vomiting. What should I avoid while giving Spironolactone to my pet:  Do not use supplements containing potassium as these could cause high levels of potassium in the body. What are the possible side effects of Spironolactone:  If any of the following serious side effects occur, stop giving spironolactone and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips; tongue or face; hives); an irregular heartbeat, shortness of breath, fatigue, confusion, weakness, numbness, or decreased urination. Other less serious side effects may occur. Continue giving spironolactone and talk to your veterinarian if your pet experiences headache, dizziness, nausea, diarrhea, decreased appetite, or dry mouth. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal. What other drugs will affect Spironolactone: Tell your veterinarian if your pet is being given probenecid, a nonsteroidal anti-inflammatory (NSAID) such as etodolac, carprofen or piroxicam or a diabetes medication such as glipizide. You should also tell your veterinarian if your pet is taking any other medication to treat high blood pressure, edema, heart problems, or some other condition. Drugs other than those listed here may also interact with spironolactone. Talk to your veterinarian before giving your pet any prescription or over the counter medicines. Where can I get more information: Your pharmacist has additional information about Spironolactone written for health professionals that you may read. Call your veterinarian for medical advice about any side effects to your pet. You may report side effects to the FDA at 1-800-FDA-1088.