Campral（商品名：坎普劳；通用名：阿坎酸[acamprosate]）用于治疗已经停止饮酒后寻求继续戒酒的酒精依赖者（alcohol dependent individuals）。Campral对于在治疗开始时仍频繁饮酒，或滥用除酒精之外的其它物质的患者，可能不具疗效。 Campral是十年来获准的第一个用于治疗酒精滥用（alcohol abuse）的新药。 酒精中毒(alcoholism)，又称酒精依赖（alcohol dependence），是一种疾病。 酒精滥用（alcohol misuse）将造成严重后果，在很多情况下，甚至是威胁生命的。 大量饮酒增加患某些癌症的风险，特别是肝脏、食管、咽和喉头等部位的癌症。大量饮酒也会引起肝硬化（liver cirrhosis）、免疫系统疾病、脑损害；如果在怀孕期，将对胎儿造成伤害。慢性酒精中毒（chronic alcoholism）一直以来都是一个普遍存在的消耗性疾病，在医疗保健费用（healthcare costs）、工资损失和个人身心痛苦等方面对社会造成巨大负担。 Campral的作用机制尚未完全明了，目前认为它是通过作用于与酒精滥用有关的脑通路。通过包括已放弃酒精摄入的酒精依赖患者（即，已戒酒者[detoxified]）的多重安慰剂对照临床试验，Campral被证明是安全和有效的。鉴于接受阿坎酸治疗的受试者中较大比例被评定为在整个治疗中达到持续性戒酒，证明Campral在维持戒酒（abstinence）（保持使患者不消费酒）中优于安慰剂。Campral没有成瘾性，并且在临床试验中普遍有良好的耐受性。所报告的患者最常见不良事件，包括头痛、腹泻、胃气胀和恶心。 Campral治疗应作为包括心理社会支持在内的综合治疗项目的一部分。 Campral的申报者是位于法国里昂的Lipha Pharmaceuticals, Inc.（利伐制药公司）。 Order Campral 333 mg today and have it delivered quickly and discreetly to your home. For many medication products on our website, a prescription is often required. In other cases, no prescription is required for OTC (over the counter) drugs. If you desire to save on drugs, one alternative to your local store is to buy from an online pharmacy like The Drug Company. The Drug Company offers medications from a wide selection of licensed pharmacies, including a Canadian pharmacy. Many people trust prescription medications from Canada, as well as all of the pharmacies in our network. About Campral What Campral is used for CAMPRAL is used to help alcohol dependent people keep from drinking alcohol. It should be used as part of a complete treatment program that includes counselling. Before beginning this medication, you should no longer be drinking alcohol. CAMPRAL has not been shown to be effective if you are still drinking when you start taking it. What Campral does CAMPRAL is believed to work by restoring the natural balance of chemicals in the brain. When Campral should not be used If you are sensitive (allergic) to CAMPRAL, or any component of this medication (see What the important nonmedicinal ingredients are:). If you suffer from severe kidney problems. If you are breast-feeding. What the medicinal ingredient is Acamprosate calcium. What the important nonmedicinal ingredients for Campral are Anionic copolymer of methacrylic acid and acrylic acid ethyl ester, colloidal anhydrous silica, crospovidone, magnesium silicate, magnesium stearate, microcrystalline cellulose, propylene glycol, sodium starch glycolate and talc. What dosage forms Campral comes in Each CAMPRAL delayed-release tablet 333 mg is available as an enteric-coated, white, round-shaped tablet with “333” on one side. Tablets are supplied in blisters of 84. Warnings and Precautions If you develop any new or worsening mental health symptoms such as depression or thoughts of suicide while taking CAMPRAL you should talk to your doctor or pharmacist immediately. The use of CAMPRAL does not eliminate or reduce the symptoms of alcohol withdrawal (the symptoms people experience when they stop drinking alcohol abruptly when they are dependent on alcohol). CAMPRAL therapy should be used as a part of a treatment program that includes counselling and support. CAMPRAL therapy should be continued as directed, even in the event of relapse (renewed drinking of alcohol) and any renewed drinking should be discussed with your doctor. BEFORE you use CAMPRAL talk to your doctor or pharmacist if: You are pregnant or likely to become pregnant. CAMPRAL could be used during pregnancy if you can not abstain from alcohol without being treated with CAMPRAL. CAMPRAL does not prevent the harmful effect on fetus of alcohol intake. Although in controlled studies CAMPRAL has not been shown to impair coordination, certain drugs (e.g. sedatives, antidepressants) may impair judgment, thinking, or motor skills. Take precaution when operating hazardous machinery, including automobiles, until you are reasonably certain that CAMPRAL therapy does not affect your ability to participate in such activities. Interactions with Campral CAMPRAL has not been shown to interact significantly with other medications. If you are currently taking a medication, whether on prescription or otherwise, inform your doctor or pharmacist. Proper Use of Campral Usual dose The recommended dose of CAMPRAL is two 333 mg tablets taken three times daily. CAMPRAL should be swallowed whole, not crushed or chewed or split, and may be taken with or without food. Treatment in patients with moderate kidney disease requires a dose reduction (one 333 mg tablet taken three times daily). Never take more than the prescribed dose. Lower dose may be prescribed temporarily for tolerability reasons. Overdose Seek emergency medical attention. Symptoms of overdose may include diarrhea. Missed dose If you miss a dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Side Effects for Campral and What to Do About Them The side effects most often seen are gastrointestinal in nature, such as diarrhea, abdominal pain, gas and nausea. If you experience any of these effects, continue taking CAMPRAL and talk to your doctor. Other less common side effects may include: Rash, itching Weight gain/loss, Change in sexual desire or ability Check with you doctor or pharmacist if you experience any unexpected effects, or are concerned by the above side effects. Campral Why is Campral prescribed? Campral is prescribed to treat alcohol dependence. It helps people who have already stopped drinking alcohol keep from starting again. You must be alcohol-free before taking Campral for it to work. You must also be prepared to follow a complete alcohol treatment plan that includes mental and behavioral health counseling. Campral is thought to work by restoring and regulating brain chemicals that have been disrupted by long-term exposure to alcohol. Campral is not used for any type of substance dependence other than alcohol. Most important fact about Campral Individuals being treated with Campral and their caregivers should be aware that alcohol dependence and mental health problems frequently occur together. Pay special attention to any worsening of depression or any new symptoms that occur while taking Campral—especially agitation, anxiety, hostility, and suicidal thoughts or behavior—and report them to the doctor immediately. How should you take Campral? Campral may be taken with food or on an empty stomach. However, taking it with meals may make it easier to keep on a regular schedule. Continue taking Campral regularly even if you experience a relapse. If you miss a dose... Take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take two doses at once. Storage instructions... Store at room temperature. What side effects may occur? Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Campral. Side effects may include: Anxiety, body pain or weakness, chest pain, depression, diarrhea, dizziness, headache, heart failure, insomnia, irregular heartbeat, kidney failure, nausea, seizure, sudden death, and suicidal thinking or suicide attempt Why should Campral not be prescribed? You cannot use Campral if you have severe kidney disease. You must also avoid the drug if it causes an allergic reaction. Special warnings about Campral You must completely avoid alcohol while taking Campral. If you begin drinking again, keep taking Campral and call your doctor right away to discuss your relapse. Campral does not relieve the symptoms of alcohol withdrawal. Use Campral with caution if you have kidney problems. Because mental health problems and alcoholism frequently occur together, tell your doctor about any change in mood or behavior while using Campral (see "Most important fact about Campral"). Campral could affect your judgment, thinking, or motor skills. Do not drive, operate dangerous machinery, or participate in hazardous activities until you know how Campral affects you. Possible food and drug interactions when taking Campral At this time, there are no documented drug interactions with Campral. However, you should always tell the doctor about any medicines you take, including over-the-counter drugs, vitamins, and herbal supplements. Special information if you are pregnant or breastfeeding Campral has not been studied in pregnant women and should be used only if the benefits outweigh the potential risks. Be sure to tell your doctor if you're pregnant or plan to become pregnant. In lab studies Campral showed up in the milk of breastfeeding animals. It is not known whether Campral appears in human breast milk. Your doctor may advise you not to breastfeed while taking Campral. Recommended dosage for Campral ADULTS The usual starting dose is two tablets (each tablet contains 333 milligrams) taken three times a day, for a total of six tablets a day. Your doctor may lower the dose as needed. People with moderate kidney disease take half the regular dose—one tablet three times a day. CHILDREN The safety and effectiveness of Campral have not been studied in children. Overdosage Any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency treatment immediately. Symptoms of Campral overdose may include diarrhea 阿坎酸钙缓释片详细的说明书 [附件:/uploadfile/article/uploadfile/201010/20101003033924977.pdf] 坎普拉尔(CAMPRAL(R))戒酒药临床资料 [附件:/uploadfile/article/uploadfile/201010/20101003055953753.pdf]