部份中文施普善处方资料（仅供参考） 通用名：脑蛋白水解物注射液 商品名：施普善 英文名：CerebroproteinHydrolysateInjection 药理作用 1.具有与天然神经生长因子相同的作用，维持神经细胞存活，诱导神经元分化，促进神经突触形成。 2.调节脑组织代谢，提高葡萄糖利用率，增加蛋白质合成。 3.降低缺血、缺氧时脑内乳酸和自由基形成。 4.抑制钙离子内流和兴奋氨基酸的神经毒性作用。 5.减轻外伤或毒性物质造成的脑组织损害。 6.提高突触的兴奋性、增强学习、记忆能力。 适应证 1.早老性痴呆、血管性痴呆。 2.缺血、出血性性中风的急性和康复期治疗。 3.脑外伤，神经外科手术后。 4.缺血、缺氧性脑病（新生儿窒息，CO中毒）。 5.病毒、细菌性脑炎的辅助治疗。 6.脑发育不良、脑瘫的辅助治疗。 7.健忘，注意力障碍。 用法和用量 静脉点滴：20-30ml加入250-500ml5%葡萄糖液或生理盐水中静脉点滴，急性病例可加大到50ml，日一次，每周5-6次，4周为一疗程。 肌肉注射：每次2-5ml，每日一次。 儿童用量酌减。 不良反应 施普善已在50多个国家广泛使用，没有发现有明显副作用或抗药性。 禁忌证 过敏体质，癫痫或痉挛发作，严重肾功能衰竭时禁用或慎用。 施普善（Cerebrolysin®） 施普善®是一种生物技术制备的肽制剂，能刺激中枢神经系统的神经营养调节。 施普善®在世界范围内广泛用于治疗缺血性与出血性卒中、创伤性颅脑损伤，也能用于治疗各种形式的痴呆（血管性痴呆与阿尔茨海默病）以及认知障碍，能够防止脑损伤后的认知衰退。 施普善®的神经保护与神经再生功能对急性或退行性神经疾病患者颇有裨益。 施普善®的肌内注射剂量可高达5毫升，静脉注射剂量可高达10毫升。如果需要更高剂量，则建议采用静脉输液（输注时间：15—60分钟）。 Cerebrolysin® 1mlx10 vials Cerebrolysin® 5ml x 5ampules Cerebrolysin® 10ml x 5via Cerebrolysin®: Cerebrolysin® is recommended in cases of organic brain dysfunction, metabolic and neurodegenerative especially senile dementia of the Alzheimer type. In cases of post-stroke complications Cerebrolysin® will speed up the recovery period. Head trauma, post-operative cerebral contusion or concussion require Cerebrolysin®. Cerebrolysin® active compound: Hydrolyzed protein of porcine brain. Cerebrolysin® ingredients: 1 (one) ml solution  for injection/infusion containing hydrolysed protein from porcine brain in the form of concentrated solution, 215.2 mg and excipients: sodium hydroxide, water for injections. Cerebrolysin® contraindications - Hypersensitivity to the hydrolyzate of porcine brain protein or any of the excipients. - Epilepsy - Severe renal impairment. Adverse reactions: In rare cases, Cerebrolysin® treatment effects were associated with: - Agitation (aggression, confusion, insomnia) - Hyperventilation, hypertonia, hypotonia, fatigue, tremor, depression, apathy, dizziness and flu symptoms (eg colds, cough, upper respiratory tract infections). During treatment with Cerebrolysin® reported one case of attack type "grand mal" seizures and - Gastrointestinal disorders such as loss of appetite, dyspepsia, diarrhea, constipation, vomiting and nausea - If too rapid injection may be a sensation of warmth or sweating, dizziness and, in isolated cases, palpitations or arrhythmias - Local reactions at the injection site, such as irritation, itching or burning sensation - In rare cases have been observed hypersensitivity or allergic reactions such as skin reactions, local reactions vascular headache, neck pain, pain in limb, fever, back pain, chills and shock. Cerebrolysin® is used in the elderly because the side effects mentioned above are typical for this population and can be observed in the absence of drug use. Directions to use the Cerebrolysin® : May be given single doses up to 50ml/BW (10,760 mg of Cerebrolysin®) but cures treatment is preferable. A cure best treatment involves administering Cerebrolysin® daily for 10-20 days. Recommended Cerebrolysin® daily dose: - Organic brain dysfunction, metabolic and neurodegenerative (dementia) is recommended daily dose of 5-30 ml / BW (1076-6456 mg of hydrolyzed porcine brain protein). - Complications post - stroke: the recommended daily dose is 10-50 ml/BW (2152-10760 mg of Cerebrolysin®). - Head trauma, post-operative cerebral contusion or concussion: Recommended daily dose of 10-50ml/BW (2152-10760 mg of Cerebrolysin®). - Children: The recommended daily dose is 1-2 ml/BW (215.2 to 430.4 mg of Cerebrolysin®). Cerebrolysin® efficacy can be increased by repeating cures, until no longer see improvements in your health. After the initial cure, Cerebrolysin® dose frequency can be reduced to 2-3 times a week. Must be left free intervals between courses, their duration is equal to the cure. May be given doses up to 5 ml/BW (1076 mg of Cerebrolysin®) and intramuscularly to 10 ml/BW (2152 mg of Cerebrolysin®) intravenously. Larger doses of 10-50 ml /BW (2152 up to a max. of 10,760 mg of Cerebrolysin®) are recommended only as a slow intravenous infusion after Cerebrolysin® dilution with infusion solutions recommended standard. The infusion must be between 15 and 60 minutes. The following standard Cerebrolysin® infusion solutions were tested for 24 hours at room temperature in the presence of light and were declared compatible: - Sodium chloride solution 0.9% (9 mg Naci/ml) - Ringer solution (Na 153.98 mmol/l, Ca 2.74 mmol/l, K> 4.02 mmol/l, Cl 163.48 mmol/l) - Glucose 5% Vitamins and cardiovascular drugs can be administered concomitantly with Cerebrolysin®, but should not be mixed in the syringe. Cerebrolysin® is not addictive and doesn't requires special precautions. Animal studies have shown reproductive toxicity. However, no studies have been performed in humans. Thus, during pregnancy and breastfeeding Cerebrolysin® should be used only after careful evaluation of the risk / benefit. Please avoid to buy Cerebrolysin® from unreliable sellers or manufacturers because it is a very sensitive product and an expired lot could lead to more damage than actual support. The original brand name Cerebrolysin® is Made in Austria. Cerebrolysin® box of 5 brown glass vials with breaking point 10ml solution for injection/infusion. •Manufactured by: EVER Neuro Pharma GmbH Austria Cerebrolysin® 10ml x 5ampules Cerebrolysin® 5ml x 5ampules Cerebrolysin® 1ml x 10via