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Composition: Protirelin tartrate 0.732 mg (as protirelin 0.5 mg)

Description: Probrin is an analogue of TRH (Thyrotropin Releasing Hormone), a neuromodulator localized in various parts of central nervous system such as hippocampus and reticular formation. It produces arousal effect and analeptic action, Protirelin tartrate also antagonizes endogenous opioids thus improves spinal cord blood flow after spinal cord injury.

Indications:

• Disturbance of consciousness after head trauma

• Continuous disturbance of consciousness after subarachnoid hemorrhage

• Spinal cord injury

Dosage: For intravenous injection, Probrin is reconstituted with 5-10 ml of physiological saline, glucose or distilled water for injection and administered at a very slow rate. Disturbance of consciousness after head trauma: 1-4 ampoules daily for 10 days by single intravenous injection or intravenous drip infusion. Continuous disturbance of consciousness after subarachnoid hemorrhage: 4 ampoules by single intravenous injection or intravenous drip infusion. Treatment should be continued depending upon the severity of the condition. Spinal cord injury: 1-4 ampoules daily for 10 days by single intravenous injection or intravenous drip infusion.

How supplied: Pack of one ml ampoule containing Protirelin tartrate 0.732 mg (as protirelin 0.5 mg)