英文药名: Proamatine(Midodrine Tablets)

中文药名: 米多君片

生产厂家: Shire

药品名称

通用名称：盐酸米多君片, 甲氧胺福林, 美多君盐酸盐
英文名称：Midodrine Hydrochloride Tablets, Proamatine, Roberts Corporation
规格

2.5mg, 5mg.
药理毒理

管通只对外周交感神经系统的a受体起作用。它能兴奋膀胱颈和后尿道a受体, 使该处的平滑肌收缩,尿道内闭合压升高,防止尿液渗漏,改善尿失禁症状。另外, 管通还能调节外周血管张力, 治疗直立性低血压和低血压。
适应症

压力性尿失禁。
低血压和直立性低血压。
用于下肢静脉充血时血循环体位性功能失调而造成的低血压,外科术后、产后失血以及气候变化、晨间起床后的疲乏所致的低血压症等。女性压力性尿失禁。
用法用量

压力性尿失禁
--成人:2.5mg(1片)至5mg(2片),每日2～3次。
直立性低血压
--成人和青少年(12岁以上):开始剂量2.5mg(1片)每 日2～3次。
根据病人的反应和对此药耐受能力,可将上述剂量每3～4天增加一次。应当在白天,病人需要起立进行日常活动时服用管通。建议服药间隔时间3～4小时。
任何疑问,请遵医嘱!
不良反应

罕见心律不齐、寒颤、皮疹,个别病人在剂量较大时可能在头、颈部引起鸡皮样疹,或有排尿不尽的感觉。
心率每分种可少于60次。

Proamatine (Midodrine) is used for certain patients having symptoms of low blood pressure when in a standing position. Proamatine (Midodrine) is used in people whose living activities are severely affected, even after other treatments are used (e.g., support stockings). Proamatine (Midodrine) should only be used in carefully selected patients. Proamatine (Midodrine) causes a significant increase in blood pressure when lying down on your back. Your blood pressure will be monitored carefully during treatment.

Proamatine (Midodrine) is taken three times daily, or as directed. Follow instructions carefully. Proamatine (Midodrine) is taken during daytime hours, when persons are upright most often. Proamatine (Midodrine) should not be taken after the evening meal or less than 4 hours before bedtime. It is recommended not to take your dose if you plan to be lying down for a long time afterward. Proamatine (Midodrine) should be continued only in those persons whose symptoms improve during treatment.

Proamatine side effects: Tingling or itching skin; chills, or urinary problems may occur. If these persist or worsen, notify your doctor promptly. Report promptly: heart pounding, slow heartbeat, unusual chest sensation, fainting, pounding sensation in the ears, headache, blurred vision. Very unlikely but report promptly: vision problems, rash. If you notice other proamatine side effects not listed above, contact your doctor or pharmacist.

Before using Proamatine (Midodrine), tell your doctor your entire medical history, including: any allergies (especially drug allergies), heart disease, liver disease, kidney disease, thyroid disease (severe hyperthyroidism), severe urination problems, diabetes, pheochromocytoma, high blood pressure. To reduce any dizziness when rising from a seated or lying position, get up slowly. Also, limit your intake of alcoholic beverages, which will aggravate this effect. Proamatine (Midodrine) should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if Proamatine (Midodrine) is excreted into breast milk. Consult your doctor before breast-feeding.

Tell your doctor of all nonprescription and prescription medication you may use, especially: digoxin, adrenaline-like drugs (e.g., phenylephrine, pseudoephedrine, ephedrine, phenylpropanolamine), dihydroergotamine, alpha blockers (e.g., prazosin, doxazosin, terazosin), drugs to control high blood pressure such as "calcium blockers" (e.g., diltiazem, verapamil), psychiatric medications (especially certain antidepressants and anti-psychosis drugs). Certain nonprescription cough-and-cold medicines and diet aids can raise your blood pressure. Consult with your pharmacist. Do not start or stop any medicine without doctor or pharmacist approval.

Do not share Proamatine (Midodrine) with others. Blood pressure checks (lying, sitting, and standing) are routinely performed. High blood pressure while lying down may be controlled in some persons by sleeping with the head of the bed elevated.

Drug Overview

Proamatine belongs to the group of a vasopressors medication and commonly used for the treatment and relieves of the symptoms of low blood pressure (such as dizziness, lightheadedness, and fainting) for people with Parkinson's disease, diabetes, Bradbury-Eggleston syndrome, and Shy-Drager syndrome. Proamatine works by constricting the blood vessels, causing an increase in blood pressure. It works by stimulating nerve endings in blood vessels, causing the blood vessels to tighten. As a result, blood pressure is increased.

Proamatine is more useful medicine, which used for those people who suffered to the problems of symptoms of low blood pressure when in a standing position. Proamatine causes constriction or tightening of the blood vessel which leads to an increase in blood pressure.

Proamatine always takes under doctor’s guidance. You continue to take it for as long as your doctor prescribes it, even if you do not feel an immediate benefit. The dose of Proamatine will be different for different patients per day, Take it two or three times a day, or otherwise as directed by your doctor. Anybody should take the recommended oral dosage of Proamatine with food and a full glass of water. Proamatine may also be used for other conditions as determined by your doctor. Proamatine is being manufactured by Shire Pharmaceuticals and available in 2.5mg or 5mg tablets.

Effects - How it works in the body

Proamatine belongs to the group of a vasopressors medication and commonly used for the treatment and relieves of the symptoms of low blood pressure (such as dizziness, lightheadedness, and fainting) for people with Parkinson's disease, diabetes, Bradbury-Eggleston syndrome, and Shy-Drager syndrome. Proamatine works by constricting the blood vessels, causing an increase in blood pressure. It works by stimulating nerve endings in blood vessels, causing the blood vessels to tighten. As a result, blood pressure is increased. Proamatine causes constriction of the smooth muscles surrounding the blood vessels. This effect narrows the width of the blood vessels, causing blood pressure to rise, thus helping to correct low blood pressure on standing.

Side Effects

Possible side effects that occurs during the uses of Proamatine:

• Allergic reaction
• High blood pressure
• Slow heartbeat
• Increased dizziness
• Fainting
• Itching
• Numbness or tingling
• Goose bumps
• Chills
• Urinary difficulties
• Headache
• Sinus pressure
• Redness of face
• Confusion
• Dry mouth
• Nervousness
• Anxiety
• Skin rash
• Vision problems
• Dizziness
• Dry skin
• Backache
• Gastrointestinal distress
• Gas
• Leg cramps
• Weakness
• Yellowed eyes and skin

Interactions

Although certain medicines should not be used together at all, so its your responsibilities that tell your doctor or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also you tell your doctor or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or addicted to illegal drugs. These may affect the working mechanism of Proamatine. In these cases, your doctor may change the dose or teach precautions may be necessary. Therefore when you are taking Proamatine, it is most important that your doctor or health care professional know if you are taking any of the following or other drugs:

• Cimetidine
• Entecavir
• Linezolid
• Metformin
• Memantine
• Ranitidine
• Triamterene
• Medicines for correcting heart rhythm problems
• Medicines for colds and breathing difficulties
• Medicines for treating depression
• Medicines for migraine
• Medicines for heart disease
• Medicines for high blood pressure
• Medicines for weight loss

Counterindications

You shouldn’t use this drug without consultation of doctor if you have an allergy to Proamatine or any other ingredients of this medicine.

You shouldn’t use Proamatine without consultation of doctor if you are suffering to the problem of decreased liver function or Asthma disease.

You shouldn’t use Proamatine without consultation of doctor if you are suffering to the problem of Kidney disease.

You shouldn’t use Proamatine without consultation of doctor if you are suffering to the problem of Heart disease or Blood disease.

You shouldn’t use Proamatine without consultation of doctor if you are suffering to the problems of diabetes mellitus.

You shouldn’t use Proamatine without consultation of doctor if you are suffering to the problem of high blood pressure.

You shouldn’t use Proamatine without consultation of doctor if you are suffering to the problem of over active thyroid.

You shouldn’t use Proamatine without consultation of doctor if you are suffering to the problem of pheochromocytoma.

You shouldn’t use Proamatine without consultation of doctor if you are suffering to the problem of urinating.

You shouldn’t use Proamatine without consultation of doctor if you are pregnant or plan to be pregnant.

You shouldn’t use Proamatine without consultation of doctor if you are suffering to breastfeeding.

Similar drugs of Proamatine

• Midrodrine
• Amatine
• Gutron
• Fludrocortisone
• Florinef
• Erythropoietin

Major drug Manufacturers

• Shire Pharmaceuticals Canada
• Douglas Pharmaceuticals Ltd.
• Roberts Pharmaceutical
• Knoll Pharmaceuticals
• 3M Pharmaceuticals
• Astra Zeneca Pharmaceuticals
• Nycomed Austria
• Bristol-Myers Squibb Pharmaceuticals

From where can one get Proamatine?

Anyone can buy Proamatine from Online Canadian Pharmacy, which is available at a discounted price, 50% off, in Canada, and the best way to get Proamatine is by logging on to  for online orders. This pharmacy provides you with drugs at cheap and affordable prices. One can order the medicine and pay through VISA, MasterCard or international money order.

Why to buy Proamatine drug from Canada?

It is cheaper to buy Proamatine from Online Canadian Pharmacy, because Canadian government regulates the prices of Proamatine and also because of the very common reason of exchange rate. Since, the Canadian dollar is cheaper as compared to the US Dollars, so one can buy more Proamatine from Canada, thereby saving a lot of money.