中文名：二巯丁二酸; 二巯基丁二酸; 2,3-二巯基丁二酸 
其他名称  Succimer、Chemet、DMS、Sodium Dimercaptobutanedioate、二巯基丁二钠、二巯基丁二酸钠、二巯基琥珀酸钠、二巯琥钠、巯琥酸钠。 

英文名：Chemet; Succimer; 2,3-Dimercaptosuccinic acid; meso-2,3-Dimercaptosuccinic acid 

药品类别：解毒药

药理药动：药理作用与其他二巯基类化合物相似。某些金属化合物进入体内后，能与细胞酶系统的巯基相结合，抑制酶的活性。本品有两个巯基，其巯基与金属结合以后，形成不易离解的无毒性络合物由尿排出。从而解除金属对酶系统的作用。

适应症：可用作铅、汞、砷、锑中毒的解毒和促排药物。对铜、金、铊、锌也有解毒作用。可提高镍、铂、银、钻、锶金属的LD50和尿中排出量，对有机砷也有解毒作用。

用法用量：口服DMSA胶囊，慢性中毒者每次0.5g，1日3～4次，连续服药3天，间歇4天为一疗程，可用4～5个疗程，以后根据情况酌情停药。

不良反应：毒性低，临床治疗中未见到有不良反应和副作用的报道。

禁忌症：对巯基类药物过敏者禁用。

【原产地英文商品名】:CHEMET 100mg/cap 100caps/bottle
【原产地英文药品名】:SUCCIMER
【中文参考商品译名】:CHEMET 100毫克/胶囊 100胶囊/瓶
【中文参考药品译名】:二巯丁二酸
【生产厂家中文参考译名】:LUNDBECK INC
【生产厂家英文名】:LUNDBECK INC

GENERIC NAME: SUCCIMER - ORAL (SUX-sim-er)

BRAND NAME(S): Chemet

USES: This medication is used to treat lead poisoning. It works by binding to the lead so that it may be removed by your kidneys. Removing lead from your body will lower the chance of severe problems caused by lead poisoning.

HOW TO USE: Take this medication by mouth with or without food, usually every 8 or 12 hours, or as directed by your doctor. Swallow the capsules whole. If you have trouble swallowing the capsule, you may open the capsule and sprinkle the contents on soft food (such as applesauce). Swallow all of the drug/food mixture immediately without chewing. You may also place the contents on a spoon and swallow with fruit juice.Dosage and length of treatment is based on your medical condition, response to treatment, and body size.Drink plenty of fluids while taking this medication unless your doctor directs you otherwise.Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same times each day.

SIDE EFFECTS: Nausea, vomiting, loss of appetite, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: signs of infection (such as fever, persistent sore throat).A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking succimer, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. However, since this medication is used for lead poisoning and lead may pass into breast milk, breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.This medication may interfere with certain laboratory tests (including uric acid levels, CPK levels, certain urine ketone tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.Keep a list of all the products you use. Share the list with your doctor and pharmacist to reduce your risk for serious medication problems.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.It is important to remove the source of lead exposure. Consult your doctor or pharmacist for details on identifying and avoiding sources of lead exposure.Laboratory and/or medical tests (such as complete blood count, blood lead levels, liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.