佳乐施(Gelofusine)是一种琥珀酰明胶类血浆代用品,用于急性失血性休克的治疗.在不影响机体正常生理功能前提下,使用血浆代用品,能够较好维持循环血容量充足、维护血流动力学稳定、保证氧供/氧耗平衡. 【通用名称】琥珀酰明胶注射液 【适应症】用于低血容量性休克、手术创伤、烧伤及感染的血容量补充,手术前后及手术间的稳定血液循环,体外循环(血液透析,人工心肺机)血液稀释,脊髓及硬膜外麻醉后的低血压的预防。 【用法用量】经静脉输注,剂量和速度取决于病人的实际情况,如脉搏、血压、外周组织灌注量、尿量等,必要时可加压输注。快速输注时应加温液体,但不超过37oC。如果血液或血浆丢失不严重,或术前或术中预防性治疗,一般1~3小时内输注500~1000ml;低血容量休克,容量补充和维持时,可在24小时内输注10~15L(但红细胞压积不应低于25%,年龄大者不应低于30%同时避免血液稀释引起的凝血异常);严重急性失血致生命垂危时,可在5~10min内加压输注500ml,进一步输注量视缺乏程度而定。 【不良反应】偶风过敏反应,可出现轻微荨麻疹。本品引起严重不良反应的发生率在1/6000和1/13000之间,由血管活性物质放引起。病人通常表现为变态反应。如病人已处于过敏状态,如哮喘,则出现反应的机会增加,程度也会加重,应慎用。一旦出现过敏反应,应立即停止输注,并根据病人情况做相应处理:更换容量替代液;抬高双腿;增加供氧;监测电解质;给予肾上腺素(1:1000浓度0.5-1.0ml肌注,必要时每15分重复一次或1:10000浓度5~10ml缓慢静滴)及大剂量肾上腺皮质激素(如泼尼松龙250-1000mg);也可使用抗菌素组胺药(如:氯苯那敏10~20mg缓慢静滴)及钙剂(小心病人服过强心苷);必要时可用利尿剂加快液体排出。 【禁忌】对本品有过敏反应的病人禁用。有循环超负荷、水潴留、严重肾功能衰竭、出血素质、肺水肿的病人禁用。 【注意事项】 【原产地英文商品名】Gelofusine Eco Bag 500ml/bag Gelofusine In the context of the replacement of specific components following blood loss, it is generally possible to avoid giving red cells until the losses amount to 20% of the total blood volume. If more than 2000-3000 mL of Gelofusine B Braun are infused pre- and intraoperatively, it is recommended that the serum protein concentration will be checked postoperatively, especially if there are signs of tissue oedema. Under certain circumstances (eg, septic shock, where there may be a need for specific globulins) a human albumen preparation may be the appropriate choice for further volume expansion. Gelofusine B Braun has no effect on blood coagulation or on renal function, even in large doses (up to 15 L in 24 hrs as part of massive transfusions). Particularly in cases of massive transfusion is it important to avoid disturbances of coagulation, other than those caused by a simple dilution effect. The simultaneous administration of blood through the same infusion set is possible. The low calcium content does not cause any coagulation of the citrated blood. Further Notes: Gelofusine B Braun is effective in maintaining blood volume, but does not adequately replace protein deficiencies associated with blood or plasma losses. Tolerance is unknown. Contraindications Special Precautions Caution in cases of overhydration, renal failure, haemorrhagic diatheses, pulmonary oedema, sodium or potassium deficiency and known hypersensitivity to components of the solution. Use in pregnancy & lactation: Pregnancy Category C: There is little information on the administration of Gelofusine B Braun to pregnant or lactating women. No embryotoxic effect has, however, hitherto been observed, but there is a little risk of severe anaphylactoid reactions. Under these circumstances this preparation should only be prescribed when the potential advantage outweighs the potential risk to the foetus. Treatment: The Gelofusine infusion should be stopped immediately. Further treatment depends on the severity of the anaphylactoid reaction: Alternative volume replacements; elevation of the legs administration of oxygen; immediate administration of adrenaline parenterally (eg, 0.5-1 mL of adrenaline 1:1000 IM, repeated if necessary, every 15 min, or 5-10 mL of adrenaline 1:10,000 slowly IV); administration of high-dose corticosteroids (eg, prednisolone 250-1000 mg); antihistamines (eg, chlorpheniramine 10-20 mg slowly IV); calcium (caution in patients being treated with cardiac glycosides); observation and treatment of the metabolic acidosis. Incompatibilities: Although electrolyte and carbohydrate solutions may be given together through the same cannula as the Gelofusine B Braun solution, this is not permitted for fat emulsions. The simultaneous administration of blood through the same infusion set is possible. The addition of drugs in aqueous solution (eg, vasoactive drugs, barbiturates, muscle relaxants, corticosteroids and antibiotics) is generally possible but not recommended. Storage Shelf-Life: 5 years. The combination of the following effects of a Gelofusine B Braun infusion produces an improved oxygen supply to the tissues: Haemodilution with Gelofusine B Braun which has a relative viscosity similar to plasma, reduces the relative viscosity of the blood. In addition, negative changes in the microcirculation are reversed, at least in part. The overall result is a considerably improved pattern of blood flow with an increased cardiac output. Gelofusine B Braun infusion reduces the haematocrit and thereby the oxygen-carrying capacity of the blood. However, the reduction in blood viscosity and the positive changes in the microcirculation reduce the workload of the heart, so that the cardiac output can be increased without any increase in myocardial oxygen consumption. The overall effect of the Gelofusine B Braun infusion, taking into account this increase in cardiac output, is to increase the oxygen transport (if the haematocrit does not sink below about 25% or in elderly patients better not below 30 %). Furthermore, the colloid osmotic properties of Gelofusine B Braun prevent or reduce the possibility of interstitial oedema, which may limit the oxygen supply to the tissues. If there is a peripheral oxygen deficit, the release of oxygen from the haemoglobin is increased, with a useful effect on the total oxygen supply to the tissues. Pharmacokinetics: Gelofusine B Braun has been shown to have a multi-phase elimination curve from the blood circulation, with a half-life of about 9 hrs (determined by a graphical technique) and a volume effect of about 5 hrs. It appears that some 75% of the infused succinylated gelatin molecules are excreted through the kidneys and about 15% in the faeces. In animal experiments, retention in the reticuloendothelial system for 24-48 hrs has been demonstrated. The fraction which is not directly excreted is broken down by proteolysis. This breakdown process is so effective that there is no accumulation even in renal failure. The dose administered is always determined by the goal of an adequate circulation. This applies even when renal excretion is reduced. |
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佳乐施(琥珀酰明胶注射液)简介:
佳乐施(Gelofusine)是一种琥珀酰明胶类血浆代用品,用于急性失血性休克的治疗.在不影响机体正常生理功能前提下,使用血浆代用品,能够较好维持循环血容量充足、维护血流动力学稳定、保证氧供/氧耗平衡. ... 关键字:佳乐施(琥珀酰明胶注射液)
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