普乐可复-Prograf 【外文名】Tacrolimus, Prograf, FK506 【药理作用】在分子水平,他克莫司的作用显然是利用与细胞性蛋白质(FK 12)相结合,而在细胞内蓄积产生效用。FK 12-他克莫司复合物会专一性地结合以及抑制calcinurin,其会抑制T细胞中所产生钙离子依赖型讯息传导路径作用,因此防止不连续性淋巴因子基因的转录。本药是具有高度免疫抑制的药物,其活性在体外及体内实验中都已被证实。本药抑制形成主要移值排斥作用之细胞毒性淋巴球的生成。本药是具有高度免疫抑制的药物,其活性在体外及体内实验中都已被证实。本药抑制形成主要移植排斥作用之细胞毒性淋巴球的生成。本药抑制T细胞的活化作用以及T辅助细胞依赖B细胞的增生作用。也会抑制如白介素-2、白介素-3及γ-干扰素等淋巴因子的生成与白介素-2受体的表达。在分子水平,本药的效应似乎是由结合到细胞性蛋白质(FK )所产生,此蛋白质也会造成该化合物累积在细胞间。在体内试验中发现,本药显示出对肝脏及肾脏移植有效。 【适应症】肝脏及肾脏移植患者的首选免疫抑制药物,肝脏及肾脏移植后排斥反应对传统免疫抑制方案耐药者,也可选用该药物。 【原产地英文商品名】PROGRAF 5mg/cap 100caps/box Generic Name: tacrolimus Brand Names: Prograf What is Prograf? Prograf is used together with other medicines to prevent your body from rejecting a heart, liver, or kidney transplant. Prograf may also be used for other purposes not listed here. Important information about Prograf While taking Prograf avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. There are many other medicines that can interact with Prograf. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. Do not consume grapefruit or grapefruit juice during treatment with Prograf unless your doctor has told you do. Prograf can have a dangerous interaction with grapefruit or grapefruit juice. Prograf can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments. Some people receiving Prograf after a kidney transplant have developed diabetes, most often in people who are Hispanic or African-American. Talk with your doctor about your individual risk of diabetes. Before taking Prograf If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before taking Prograf, tell your doctor if you have: Some people receiving Prograf after a kidney transplant have developed diabetes. This effect has been seen most often in people who are Hispanic or African-American. Talk with your doctor about your individual risk of diabetes if you have concerns. Taking Prograf may increase your risk of developing certain types of cancer, especially skin cancer. The risk may be higher in people who are treated over long periods of time with drugs that weaken the immune system. Talk with your doctor about your individual risk. |
普乐可复(无水他克莫司胶囊)简介:
普乐可复-Prograf【别名】他克莫司,大环哌南,普乐可复
【外文名】Tacrolimus, Prograf, FK506
【药理作用】在分子水平,他克莫司的作用显然是利用与细胞性蛋白质(FK 12)相结合,而在细胞内蓄积产 ... 关键字:普乐可复(无水他克莫司胶囊)
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